{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T07:14:31Z","timestamp":1794640471208,"version":"4.9.1"},"reference-count":10,"publisher":"FapUNIFESP (SciELO)","issue":"3b","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:p>OBJECTIVE: To report a case of subependymal giant cell astrocytoma (SEGA) in a patient with tuberous sclerosis, emphasizing the proton MR spectroscopy (MRS) findings. CASE: A three year-old boy with tuberous sclerosis presented with a 3-month history of mild headache. The physical examination showed discrete mental retardation and multiple hypomelanic macules in the legs and back. MRI showed many cortical tubers and subependymal nodules. At the left foramen of Monro, there was a 15 mm nodule, with heterogeneous signal on T1 and T2-weighted images, and strong enhancement after contrast administration. MRS study (multi-voxel PRESS, TE=144ms) showed the following ratios: a) left foramen of Monro nodule N-acetylaspartate (NAA)\/creatine (Cr)=0.93 and Choline (Cho)\/Cr=1.6 and b) at the right Monro foramen NAA\/Cr=1.56 and Cho\/Cr=1.29. CONCLUSION: The MRS performed at the SEGA may show high Cho\/Cr and low NAA\/Cr ratios, similar to the other brain neoplasms. As a consequence, MRS may be a valuable tool for the early detection of neoplastic transformation of subependymal nodules near the foramina of Monro in patients with tuberous sclerosis.<\/jats:p>","DOI":"10.1590\/s0004-282x2006000500033","type":"journal-article","created":{"date-parts":[[2006,10,19]],"date-time":"2006-10-19T10:42:52Z","timestamp":1161254572000},"page":"877-880","source":"Crossref","is-referenced-by-count":18,"title":["Subependymal giant cell astrocytoma with high choline\/creatine ratio on proton MR spectroscopy"],"prefix":"10.1590","volume":"64","author":[{"given":"Arnolfo de","family":"Carvalho Neto","sequence":"first","affiliation":[{"name":"University of Parana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emerson L.","family":"Gasparetto","sequence":"additional","affiliation":[{"name":"Diagn\u00f3stico Avan\u00e7ado por Imagem,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isac","family":"Bruck","sequence":"additional","affiliation":[{"name":"University of Parana"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1053\/ejpn.2001.0538","article-title":"Tuberous sclerosis complex: a review of neurological aspects","volume":"6","author":"Curatolo P","year":"2002","journal-title":"Eur J Paed Neurol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1067\/mjd.2001.111627","article-title":"Tuberous sclerosis: Part I Clinical and central nervous system findings.","volume":"45","author":"Caldemeyer KS","year":"2001","journal-title":"J Am Acad Dermatol","ISSN":"https:\/\/id.crossref.org\/issn\/0190-9622","issn-type":"print"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1177\/088307380001501003","article-title":"Usefulness of diagnostic 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astrocytoma in children with tuberous sclerosis","volume":"66","author":"Nabbout R","year":"1999","journal-title":"J Neurol Neurosurg Psychiatry","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3050","issn-type":"print"},{"key":"ref7","first-page":"907","article-title":"MR imaging of tuberous sclerosis in neonates and young infants","volume":"20","author":"Baron Y","year":"1999","journal-title":"Am J Neuroradiol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1055\/s-2001-13580","article-title":"Subependymal giant-cell astrocytoma in tuberous sclerosis: endoscopic images and the implications for therapy","volume":"44","author":"Beems T","year":"2001","journal-title":"Minim Invasive Neurosurg","ISSN":"https:\/\/id.crossref.org\/issn\/0946-7211","issn-type":"print"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1034\/j.1600-0404.2000.102003175.x","article-title":"Magnetic resonance spectroscopy of tubers in patients with tuberous sclerosis","volume":"102","author":"Mizuno S","year":"2000","journal-title":"Acta Neurol Scand","ISSN":"https:\/\/id.crossref.org\/issn\/0001-6314","issn-type":"print"},{"key":"ref10","first-page":"1920","article-title":"Proton MR spectroscopy of cortical tubers in adults with tuberous sclerosis complex","volume":"22","author":"Mukonoweshuro W","year":"2001","journal-title":"Am J Neuroradiol"}],"container-title":["Arquivos de 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