{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T03:10:36Z","timestamp":1648609836568},"reference-count":27,"publisher":"FapUNIFESP (SciELO)","issue":"2A","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:p>INTRODU\u00c7\u00c3O: A apolipoprote\u00edna E (apo E) \u00e9 reconhecida como fator de risco para doen\u00e7a de Alzheimer (DA). OBJETIVO: Analisar o polimorfismo da apo E nos familiares em primeiro grau de pacientes com DA familial ou espor\u00e1dica do tipo tardio, comparando a fam\u00edlias sem DA. M\u00c9TODO: Foram estudados 40 pacientes com DA familial ou espor\u00e1dica do tipo tardio, sendo os grupos classificados como prov\u00e1vel, segundo crit\u00e9rios da NINCS-ADRDA. RESULTADO: O alelo \u00e9psilon3 foi o mais freq\u00fcente em todos os grupos. Observou-se freq\u00fc\u00eancia mais elevada de \u00e9psilon4 comparando os familiares dos probandos aos do grupo controle (p&lt;0,0001). O alelo \u00e9psilon2 mostrou diferen\u00e7a significante apenas entre familiares do grupo controle e DA familial (p=0,026). CONCLUS\u00c3O: O polimorfismo da apo E n\u00e3o diferencia DA familial da espor\u00e1dica. O estudo de fam\u00edlias permite amplificar a representatividade dos alelos \u00e9psilon2 e \u00e9psilon4, revelando, seu valor como fator protetor e de risco para DA, respectivamente.<\/jats:p>","DOI":"10.1590\/s0004-282x2007000200020","type":"journal-article","created":{"date-parts":[[2007,9,28]],"date-time":"2007-09-28T03:00:34Z","timestamp":1190948434000},"page":"295-298","source":"Crossref","is-referenced-by-count":2,"title":["Polimorfismo da apolipoprote\u00edna e nos familiares em primeiro grau de pacientes com doen\u00e7a de Alzheimer familial ou espor\u00e1dica"],"prefix":"10.1590","volume":"65","author":[{"given":"Jo\u00e3o de Castilho","family":"Ca\u00e7\u00e3o","sequence":"first","affiliation":[{"name":"FAMERP"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorot\u00e9ia Rossi Silva","family":"Souza","sequence":"additional","affiliation":[{"name":"FAMERP"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waldir 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genetics of Alzheimer\u2019s disease","volume":"50","author":"Clark RF","year":"1993","journal-title":"Arch Neurol","ISSN":"http:\/\/id.crossref.org\/issn\/0003-9942","issn-type":"print"},{"key":"ref3","series-title":"Diagnostic and statistical manual of mental disorders","year":"1994","edition":"4"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer\u2019s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task force on Alzheimer\u2019s disease","volume":"34","author":"Mckhan G","year":"1984","journal-title":"Neurology","ISSN":"http:\/\/id.crossref.org\/issn\/0028-3878","issn-type":"print"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/ana.410380105","article-title":"Apolipoprotein E genotyping in the differential diagnosis, not prediction, of Alzheimer\u2019s disease","volume":"38","author":"Roses AD","year":"1995","journal-title":"Ann Neurol","ISSN":"http:\/\/id.crossref.org\/issn\/0364-5134","issn-type":"print"},{"key":"ref6","first-page":"9","article-title":"Epidemiology of dementia: American Academy of Neurology","volume":"4","author":"Mortimer JA","year":"1994","journal-title":"Annual Meeting Courses"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3233\/JAD-2001-3114","article-title":"The neuronal endosomal-lysosomal system in Alzheimer\u2019s disease","volume":"3","author":"Nixon RA","year":"2001","journal-title":"J Alzheimer\u2019s Dis"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1001\/jama.1997.03550160069041","article-title":"Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease","volume":"278","author":"Farrer LA","year":"1997","journal-title":"JAMA","ISSN":"http:\/\/id.crossref.org\/issn\/0098-7484","issn-type":"print"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1590\/S0004-282X2001000100004","article-title":"Apo e4 and Alzheimer\u2019s disease: positive association in a Colombian clinical series and review of the Latin-American studies","volume":"59","author":"Jacquier M","year":"2001","journal-title":"Arq Neuropsiquiatr","ISSN":"http:\/\/id.crossref.org\/issn\/0004-282X","issn-type":"print"},{"key":"ref10","first-page":"S27","article-title":"Polimorfismo dos genes da apolipoprote\u00edna E e de sua regi\u00e3o promotora e da prote\u00edna relacionada ao receptor LDL em pacientes com doen\u00e7a de Alzheimer e controles: resultados preliminares","volume":"59","author":"Bahia VS","year":"2001","journal-title":"Arq Neuropsiquiatr","ISSN":"http:\/\/id.crossref.org\/issn\/0004-282X","issn-type":"print"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/(SICI)1096-8628(19970418)74:2<216::AID-AJMG22>3.0.CO;2-K","article-title":"The use of apolipoprotein E genotype for preclinical detection of risk\u2019s group for Alzheimer\u2019s disease","volume":"74","author":"Oliveira JR","year":"1997","journal-title":"Am J Med Genet","ISSN":"http:\/\/id.crossref.org\/issn\/0148-7299","issn-type":"print"},{"key":"ref12","first-page":"98","article-title":"Polimorfismo da apolipoprote\u00edna E na doen\u00e7a de Alzheimer tipo tardio: resultados preliminares","volume":"25","author":"Souza DRS","year":"1998","journal-title":"Rev Psiq Cl\u00edn (S\u00e3o Paulo)"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1590\/S0004-282X1997000100001","article-title":"Apolipoprotein e4 and Alzheimer\u2019s disease in S\u00e3o Paulo-Brazil","volume":"55","author":"Almeida OP","year":"1997","journal-title":"Arq Neuropsiquiatr","ISSN":"http:\/\/id.crossref.org\/issn\/0004-282X","issn-type":"print"},{"issue":"Supp","key":"ref14","first-page":"S215","article-title":"Determina\u00e7\u00e3o das variantes al\u00e9licas da apo E em pacientes com doen\u00e7a de Alzheimer no Rio Grande do Sul","volume":"20","author":"Larrandaburu M","year":"1997","journal-title":"Rev Bras Gen"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1590\/S0100-879X2000000500007","article-title":"Association of apolipoprotein E polymorphism with plasma lipids and Alzheimer\u2019s disease in a Southern Brazilian population","volume":"33","author":"Andrade FM","year":"2000","journal-title":"Braz J Med Biol Res","ISSN":"http:\/\/id.crossref.org\/issn\/0100-879X","issn-type":"print"},{"key":"ref16","first-page":"S26","article-title":"Polimorfismo da apolipoproteina E nos familiares em primeiro grau de pacientes com doen\u00e7a de Alzheimer: resultados preliminares","volume":"59","author":"Ca\u00e7\u00e3o JC","year":"2001","journal-title":"Arq Neuropsiquiatr","ISSN":"http:\/\/id.crossref.org\/issn\/0004-282X","issn-type":"print"},{"key":"ref17","first-page":"1","article-title":"Association of apolipoprotein E polymorphism in late-onset Alzheimer\u2019s disease and vascular dementia in Brazilians","volume":"36","author":"Souza DRS","year":"2003","journal-title":"Braz J Med Biol Res","ISSN":"http:\/\/id.crossref.org\/issn\/0100-879X","issn-type":"print"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1212\/WNL.51.3.728","article-title":"The incidence of dementia: a meta-analysis","volume":"51","author":"Jorm AF","year":"1998","journal-title":"Neurology","ISSN":"http:\/\/id.crossref.org\/issn\/0028-3878","issn-type":"print"},{"key":"ref19","series-title":"Perfil cl\u00ednico e demogr\u00e1fico das dem\u00eancias em uma popula\u00e7\u00e3o ambulatorial de um hospital geral","author":"Godoy MRP","year":"1999"},{"key":"ref20","first-page":"70","article-title":"Estudo epidemiol\u00f3gico populacional de dem\u00eancia na cidade de Catanduva, estado de S\u00e3o Paulo, Brasil","volume":"25","author":"Herrera E","year":"1998","journal-title":"Rev Psiquiatr Cl\u00edn (S\u00e3o Paulo)"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1126\/science.8346443","article-title":"Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer\u2019s disease in late onset families","volume":"261","author":"Corder EH","year":"1993","journal-title":"Science","ISSN":"http:\/\/id.crossref.org\/issn\/0036-8075","issn-type":"print"},{"key":"ref22","first-page":"643","article-title":"Apolipoprotein E: risk factor for Alzheimer disease","volume":"54","author":"Tsai MS","year":"1994","journal-title":"Am J Hum Genet","ISSN":"http:\/\/id.crossref.org\/issn\/0002-9297","issn-type":"print"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1146\/annurev.ne.19.030196.000413","article-title":"Apolipoprotein E and Alzheimer\u2019s disease","volume":"19","author":"Strittmatter WJ","year":"1996","journal-title":"Annu Rev Neurosci","ISSN":"http:\/\/id.crossref.org\/issn\/0147-006X","issn-type":"print"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/01.ATV.8.1.1","article-title":"Apolipoprotein E polymorphism and atherosclerosis","volume":"8","author":"Davignon J","year":"1988","journal-title":"Arteriosclerosis","ISSN":"http:\/\/id.crossref.org\/issn\/0276-5047","issn-type":"print"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/372045a0","article-title":"Alzheimer\u2019s disease: risk apolipoprotein in brain","volume":"372","author":"Goedert M","year":"1994","journal-title":"Nature","ISSN":"http:\/\/id.crossref.org\/issn\/0028-0836","issn-type":"print"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1056\/NEJM199802193380804","article-title":"Utility of the apolipoprotein E genotype in the diagnosis of Alzheimer\u2019s disease: Alzheimer\u2019s Disease Centers Consortium on Apolipoprotein E and Alzheimer\u2019s Disease","volume":"338","author":"Mayeux R","year":"1998","journal-title":"N Engl J Med","ISSN":"http:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/0140-6736(93)91705-Q","article-title":"Apolipoprotein E polymorfism and alzheimer\u2019s disease","volume":"342","author":"Poirier J","year":"1993","journal-title":"Lancet","ISSN":"http:\/\/id.crossref.org\/issn\/0099-5355","issn-type":"print"}],"container-title":["Arquivos de 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