{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T07:21:07Z","timestamp":1787728867455,"version":"build-2784847793"},"reference-count":23,"publisher":"FapUNIFESP (SciELO)","issue":"2b","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:p>A s\u00edndrome de Crouzon \u00e9 caracterizada por deformidade craniana, altera\u00e7\u00f5es faciais e exoftalmia. O retardo no desenvolvimento neuropsicomotor \u00e9 observado em alguns casos. Este estudo tem como objetivo analisar a influ\u00eancia do momento da cirurgia, da classe s\u00f3cio-econ\u00f4mica associada ao n\u00edvel educacional dos pais e da ocorr\u00eancia de malforma\u00e7\u00f5es do sistema nervoso central no desenvolvimento cognitivo destes pacientes correlacionando estes achados \u00e0 qualidade de vida deles e de suas fam\u00edlias. Foram estudados 11 pacientes com diagn\u00f3stico de s\u00edndrome de Crouzon com idade entre um ano e quatro meses e treze anos. A avalia\u00e7\u00e3o multidisciplinar dos pacientes incluiu, avalia\u00e7\u00e3o social, avalia\u00e7\u00e3o cognitiva, estudo do enc\u00e9falo por resson\u00e2ncia magn\u00e9tica e avalia\u00e7\u00e3o da qualidade de vida. O quociente de intelig\u00eancia variou de 46 a 102 (m=84,2) e foi correlacionado de forma inversa com o Fator 4 do Question\u00e1rio de Recursos e Estresse Simplificado (incapacidade da crian\u00e7a); n\u00e3o se correlacionou com as altera\u00e7\u00f5es encef\u00e1licas, com a condi\u00e7\u00e3o s\u00f3cio-econ\u00f4mica dos pais e nem com o momento do tratamento neurocir\u00fargico.<\/jats:p>","DOI":"10.1590\/s0004-282x2007000300020","type":"journal-article","created":{"date-parts":[[2007,9,28]],"date-time":"2007-09-28T03:04:38Z","timestamp":1190948678000},"page":"467-471","source":"Crossref","is-referenced-by-count":10,"title":["S\u00edndrome de crouzon: fatores envolvidos no desenvolvimento neuropsicologico e na qualidade de vida"],"prefix":"10.1590","volume":"65","author":[{"given":"Adriano","family":"Yacubian-Fernandes","sequence":"first","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Brasil; Universidade Estadual Paulista, Brasil; USP, 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