{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T14:46:38Z","timestamp":1649083598438},"reference-count":30,"publisher":"FapUNIFESP (SciELO)","issue":"3b","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:p>INTRODUCTION: The concentration of 2,3-diphosphoglycerate (2,3-DPG\/Hct) increases as a physiological occurrence to pH increase and hyperventilation. This response was tested in patients with severe traumatic brain injury (TBI). METHOD: The concentration of 2,3-DPG\/Hct was measured daily for six days in eleven patients with severe TBI in need of optimized hyperventilation because of intracranial hypertension. RESULTS:There was correlation between pH and the concentration of DPG\/Hct. The concentration of 2,3-DPG\/Hct remained predominantly within normal levels with slight increase in the sixth day of the study. The concentration of 2,3-DPG\/Hct correlated significantly with measured partial pressure of oxygen that saturates 50% the hemoglobin of the blood (P50st), confirming the consistency of our data. CONCLUSION: The expected physiological response of a progressive increase in concentration of 2,3-DPG\/Hct to hyperventilation was not observed. This fact may be explained by the intermittent and not sustained hyperventilation as dictated by the protocol of optimized ventilation.<\/jats:p>","DOI":"10.1590\/s0004-282x2007000500002","type":"journal-article","created":{"date-parts":[[2007,11,16]],"date-time":"2007-11-16T08:52:58Z","timestamp":1195203178000},"page":"739-744","source":"Crossref","is-referenced-by-count":1,"title":["Optimized hyperventilation preserves 2,3-diphosphoglycerate in severe traumatic brain injury"],"prefix":"10.1590","volume":"65","author":[{"given":"Rayne Borges","family":"Torres","sequence":"first","affiliation":[{"name":"Faculdades Integradas de Patos, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato Giuseppe Giovanni","family":"Terzi","sequence":"additional","affiliation":[{"name":"UNICAMP"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ant\u00f4nio Lu\u00eds Eiras","family":"Falc\u00e3o","sequence":"additional","affiliation":[{"name":"UNICAMP; 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