{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T16:30:20Z","timestamp":1771864220100,"version":"3.50.1"},"reference-count":25,"publisher":"FapUNIFESP (SciELO)","issue":"4b","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:p>BACKGROUND: Clinical and experimental evidence suggests that chronic obstructive pulmonary disease (COPD) is associated with a variety of mental symptoms that range from cognitive slowing to mental confusion and dementia. PURPOSE: To test the hypothesis that COPD leads to cognitive impairment in the absence of acute confusion or dementia. METHOD: The global cognitive status of 30 patients with COPD without dementia or acute confusion and 34 controls was assessed with a Brazilian version of the Mini-Mental State Exam (MMSE). RESULTS: The MMSE scores were significantly lower in the patient group and inversely related to the severity of COPD. This finding could not be attributed to age, education, gender, daytime sleepiness, hypoxemia, chronic tobacco use, or associated diseases such as diabetes, depression, high blood pressure or alcoholism. CONCLUSION: These results suggest the existence of a subclinical encephalopathy of COPD characterized by a subtle impairment of global cognitive ability.<\/jats:p>","DOI":"10.1590\/s0004-282x2007000700012","type":"journal-article","created":{"date-parts":[[2008,3,13]],"date-time":"2008-03-13T01:20:35Z","timestamp":1205371235000},"page":"1154-1157","source":"Crossref","is-referenced-by-count":9,"title":["Subclinical encephalopathy in chronic obstructive pulmonary disease"],"prefix":"10.1590","volume":"65","author":[{"given":"Olga Maria Pinto de","family":"Lima","sequence":"first","affiliation":[{"name":"Universidade Federal do Estado do Rio de Janeiro,  Brazil; Universidade Federal Fluminense,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo de","family":"Oliveira-Souza","sequence":"additional","affiliation":[{"name":"Universidade Federal do Estado do Rio de Janeiro,  Brazil; Universidade Federal Fluminense,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar da Rosa","family":"Santos","sequence":"additional","affiliation":[{"name":"Universidade Federal do Estado do Rio de Janeiro,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro Ara\u00fajo de","family":"Moraes","sequence":"additional","affiliation":[{"name":"Universidade Federal do Estado do Rio de Janeiro,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo Fontenelle de","family":"S\u00e1","sequence":"additional","affiliation":[{"name":"Universidade Federal do Estado do Rio de Janeiro,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osvaldo J.M.","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1056\/NEJM195709262571301","article-title":"Neurologic manifestations of chronic pulmonary insufficiency","volume":"257","author":"Austen FK","year":"1957","journal-title":"N Eng J Med","ISSN":"https:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"829","DOI":"10.7326\/0003-4819-63-5-829","article-title":"Hypercapnia: Mental changes and extrapulmonary complications. 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Med","ISSN":"https:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"key":"ref10","first-page":"S4","article-title":"I Consenso Brasileiro de Doen\u00e7a Pulmonar Obstrutiva Cr\u00f4nica (DPOC)","volume":"26","year":"2000","journal-title":"J Pneumol","ISSN":"https:\/\/id.crossref.org\/issn\/0102-3586","issn-type":"print"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1001\/jama.1993.03500180078038","article-title":"Population-based norms for the mini-mental state examination by age and educational level","volume":"269","author":"Crum RM","year":"1993","journal-title":"JAMA","ISSN":"https:\/\/id.crossref.org\/issn\/0098-7484","issn-type":"print"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1590\/S0004-282X2003000500014","article-title":"Sugest\u00f5es para o uso do mini-exame do estado mental no Brasil","volume":"61","author":"Brucki MDS","year":"2003","journal-title":"Arq 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