{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T23:19:16Z","timestamp":1761952756236,"version":"build-2065373602"},"reference-count":25,"publisher":"FapUNIFESP (SciELO)","issue":"3a","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:p>The main objectives of this study are to evaluate the resistance rates of Streptococcus pneumonia to penicillin G, ceftriaxone and vancomycin in patients with meningitis; to analyze possible risk factors to the antimicrobian resistance; to describe the serotypes detected and to suggest an initial empirical treatment for meningitis. The sensitiveness and serotypes of all isolated S. pneumoniae of patients with acute bacterial meningitis received by the Paran\u00e1 State Central Laboratory from April 2001 to august 2002 have been evaluated. One hundred S. pneumoniae have been isolated, of which 15% were resistant to penicillin, 1% to cephalosporin and 0% to vancomycin. The serotypes most found were 14 (19%), 3 and 23F (10% each). When only the resistant serotypes were analyzed, the most prevalent was the 14 with 44%. The risk factors found in relation to the S. pneumoniae resistance were: age under one year old (p=0.01) and previous use of antibiotic (p=0.046). The resistance rates found, which were moderate to penicillin, low to cephalosporin and neutral to vancomycin, suggest the isolated use of a 3rd generation cephalosporin as an initial empirical therapy for the treatment of acute bacterial meningitis with a communitarian background.<\/jats:p>","DOI":"10.1590\/s0004-282x2008000400014","type":"journal-article","created":{"date-parts":[[2008,9,29]],"date-time":"2008-09-29T14:05:10Z","timestamp":1222697110000},"page":"509-515","source":"Crossref","is-referenced-by-count":10,"title":["Acute bacterial meningitis caused by Streptococcus pneumoniae resistant to the antimicrobian agents and their serotypes"],"prefix":"10.1590","volume":"66","author":[{"given":"Andrea Maciel de Oliveira","family":"Rossoni","sequence":"first","affiliation":[{"name":"Federal University of Paran\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Libera Maria","family":"Dalla Costa","sequence":"additional","affiliation":[{"name":"Federal University of Paran\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denize Bonato","family":"Berto","sequence":"additional","affiliation":[{"name":"Central Laboratory of the State of Paran\u00e1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00f4nia Santos","family":"Farah","sequence":"additional","affiliation":[{"name":"Central Laboratory of the State of Paran\u00e1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilene","family":"Gelain","sequence":"additional","affiliation":[{"name":"Central Laboratory of the State of Paran\u00e1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Cristina de Cunto","family":"Brandileone","sequence":"additional","affiliation":[{"name":"Adolfo Lutz Institute"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vitor Hugo Mariano","family":"Ramos","sequence":"additional","affiliation":[{"name":"Federal University of Paran\u00e1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio Monteiro de","family":"Almeida","sequence":"additional","affiliation":[{"name":"Federal University of Paran\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"series-title":"CIDS\/DDI, Sistema de Informa\u00e7\u00e3o de Agravos de Notifica\u00e7\u00e3o, Banco 2002-2007","key":"ref1"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1089\/mdr.1995.1.115","article-title":"Pneumococcal resistance to \u00df-lactam antibiotics: a global geographic overview","volume":"1","author":"Baquero F","year":"1995","journal-title":"Microb Drug Resist","ISSN":"https:\/\/id.crossref.org\/issn\/1076-6294","issn-type":"print"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.3201\/eid0812.020178","article-title":"Antimicrobial resistance in Streptococcus pneumoniae, Taiwan","volume":"8","author":"Hsueh PR","year":"2002","journal-title":"Emerg Infect Dis","ISSN":"https:\/\/id.crossref.org\/issn\/1080-6040","issn-type":"print"},{"year":"2000","series-title":"Informe regional de SIREVA: II. 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