{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:28:43Z","timestamp":1790987323231,"version":"4.1.0"},"reference-count":15,"publisher":"FapUNIFESP (SciELO)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:p>This study was thought to characterized clinical and laboratory findings of a narcoleptic patients in an out patients unit at S\u00e3o Paulo, Brazil. METHOD: 28 patients underwent polysomnographic recordings (PSG) and Multiple Sleep Latency Test (MSLT) were analyzed according to standard criteria. The analysis of HLADQB1*0602 allele was performed by PCR. The Hypocretin-1 in cerebral spinal fluid (CSF) was measured using radioimmunoassay. Patients were divided in two groups according Hypocretin-1 level: Normal (N) - Hypocretin-1 higher than 110pg\/ml and Lower (L) Hypocretin-1 lower than 110 pg\/ml. RESULTS: Only 4 patients of the N group had cataplexy when compared with 14 members of the L group (p=0.0002). DISCUSSION: This results were comparable with other authors, confirming the utility of using specific biomarkers (HLA-DQB1*0602 allele and Hypocretin-1 CSF level) in narcolepsy with cataplexy. However, the HLADQB1*0602 allele and Hypocretin-1 level are insufficient to diagnose of narcolepsy without cataplexy.<\/jats:p>","DOI":"10.1590\/s0004-282x2010000500007","type":"journal-article","created":{"date-parts":[[2010,10,28]],"date-time":"2010-10-28T02:08:09Z","timestamp":1288231689000},"page":"712-715","source":"Crossref","is-referenced-by-count":9,"title":["Traditional biomarkers in narcolepsy: experience of a Brazilian sleep centre"],"prefix":"10.1590","volume":"68","author":[{"given":"Fernando Morgadinho Santos","family":"Coelho","sequence":"first","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo,  Brazil; Israelita Albert Einstein Hospital,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcia","family":"Pradella-Hallinan","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Pedrazzoli","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Augusto Senne","family":"Soares","sequence":"additional","affiliation":[{"name":"Israelita Albert Einstein Hospital,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Bruniera Peres","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Israelita Albert Einstein Hospital,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 Leite","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Israelita Albert Einstein Hospital,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Tufik","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lia Rita Azeredo","family":"Bittencourt","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","series-title":"Narcolepsy: diagnosis and management in sleep disorders. 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