{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T23:07:52Z","timestamp":1762297672334},"reference-count":19,"publisher":"FapUNIFESP (SciELO)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:p>Restless legs syndrome (RLS) is a neurological disorder that responds to dopaminergic drugs, indicating a common pathophysiology with Parkinson's disease (PD). The prevalence of RLS was estimated in a group of PD patients and its clinical and biochemical characteristics were analysed. Forty-eight patients with PD were evaluated into two groups, with and without RLS. Clinical characteristics assessed in both groups were age, gender, duration of PD, Hoehn and Yahr, and Schwab and England scales. Laboratory variables such as hemoglobin, s-iron, s-ferritin and creatinine were obtained. The prevalence of RLS was 18.75%. No significant differences regarding clinical variables and biochemical parameters were observed. The high prevalence of RLS found in PD patients suggests the concept of a common etiological link and it seems that secondary causes did not play a central role in the pathophysiology of RLS in this group of parkinsonian patients.<\/jats:p>","DOI":"10.1590\/s0004-282x2010000600007","type":"journal-article","created":{"date-parts":[[2011,2,24]],"date-time":"2011-02-24T19:13:52Z","timestamp":1298574832000},"page":"869-872","source":"Crossref","is-referenced-by-count":22,"title":["Restless legs syndrome in Parkinson's disease: clinical characteristics and biochemical correlations"],"prefix":"10.1590","volume":"68","author":[{"given":"Tiago Machado","family":"Guerreiro","sequence":"first","affiliation":[{"name":"Federal University of Sergipe"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danilo Ryuko C\u00e2ndido","family":"Nishikawa","sequence":"additional","affiliation":[{"name":"Federal University of Sergipe"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lis Campos","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Federal University of Sergipe"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyder Arag\u00e3o de","family":"Melo","sequence":"additional","affiliation":[{"name":"Federal University of Sergipe"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto C\u00e9sar Pereira do","family":"Prado","sequence":"additional","affiliation":[{"name":"Federal University of Sergipe"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","first-page":"179","article-title":"Restless legs syndrome: a clinical study in adult general population and in uremic patients","volume":"129","author":"Miranda M","year":"2001","journal-title":"Rev M\u00e9d Chile"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1001\/archinte.165.11.1286","article-title":"Restless legs syndrome prevalence and impact: REST general population study","volume":"165","author":"Allen RP","year":"2005","journal-title":"Arch Intern Med","ISSN":"http:\/\/id.crossref.org\/issn\/0003-9926","issn-type":"print"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"204","DOI":"10.34024\/rnc.2006.v14.8744","article-title":"S\u00edndrome das pernas inquietas: artigo de revis\u00e3o","volume":"14","author":"Al\u00f3e F","year":"2006","journal-title":"Rev Neuroci\u00eancias"},{"key":"ref4","series-title":"Principes and practice of sleep medicine","first-page":"830","volume-title":"Restless legs syndrome and Periodic limb movement disorders","author":"Montplaisir J","year":"2005"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.ncl.2009.04.007","article-title":"Restless legs syndrome","volume":"27","author":"Ondo WG","year":"2009","journal-title":"Neurol Clin","ISSN":"http:\/\/id.crossref.org\/issn\/0733-8619","issn-type":"print"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.1212\/WNL.61.6_suppl_3.S49","article-title":"Restless legs syndrome and PD: a review of the evidence for a possible association","volume":"65","author":"Borrreguero DG","year":"2003","journal-title":"Neurology","ISSN":"http:\/\/id.crossref.org\/issn\/0028-3878","issn-type":"print"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0022-510X(02)00020-5","article-title":"Restless legs syndrome in Parkinson's disease","volume":"102","author":"Tan EK","year":"2002","journal-title":"J Neurol Sci","ISSN":"http:\/\/id.crossref.org\/issn\/0022-510X","issn-type":"print"},{"key":"ref8","first-page":"634","article-title":"Toward a better definition of the restless legs syndrome: the International Restless Legs Syndrome Study Group","volume":"10","author":"Walters AS","year":"1995","journal-title":"Mov Disord","ISSN":"http:\/\/id.crossref.org\/issn\/0855-3185","issn-type":"print"},{"key":"ref9","series-title":"Restless legs syndrome: International Classification of Sleep Disorders. 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