{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:47:53Z","timestamp":1772171273051,"version":"3.50.1"},"reference-count":24,"publisher":"FapUNIFESP (SciELO)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:p>The purpose of this study was to investigate if botulinum neurotoxin type-A (BoNT\/A) had a preemptive antinociceptive effect in a formalin-induced orofacial pain model (FT). To test this hypothesis, male Rattus norvegicus were injected with isotonic saline solution 0.9% or BoNT\/A administered as a 40 \u03bcl bolus, lateral to their nose, at 24 hours, 8, 15, 22, 29 or 36 days pre-FT. The procedures were repeated 42 days later. Influence on motor activity was assessed through the open-field test. Pain scores corresponded to the time spent rubbing and flicking the injected area. Animals pre-treated with BoNT\/A at the first protocol (8 days subgroup) showed reduced inflammatory scores (p=0.011). For the other groups no significant results were observed at any phase. Motor activity was similar in both groups. BoNT\/A showed to be effective preventing inflammatory pain up to eight days after the first treatment, an effect not reproduced on the second dose administration.<\/jats:p>","DOI":"10.1590\/s0004-282x2011000100012","type":"journal-article","created":{"date-parts":[[2011,4,9]],"date-time":"2011-04-09T17:07:25Z","timestamp":1302368845000},"page":"56-63","source":"Crossref","is-referenced-by-count":11,"title":["Botulinum toxin type-A effect as a preemptive treatment in a model of acute trigeminal pain: a pre-clinical double-blind and placebo-controlled study"],"prefix":"10.1590","volume":"69","author":[{"given":"Elcio Juliato","family":"Piovesan","sequence":"first","affiliation":[{"name":"Universidade Federal do Paran\u00e1, Brazil; Experimental Neurology Lab"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas da Silva","family":"Leite","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1, Brazil; Experimental Neurology 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