{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:31:45Z","timestamp":1791189105693,"version":"4.1.0"},"reference-count":20,"publisher":"FapUNIFESP (SciELO)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:p>OBJECTIVE: To evaluate the comorbidity of depressive disorders in patients with refractory temporal lobe epilepsy (TLE). METHOD: We evaluated 25 consecutive patients with refractory TLE (16 women and 9 men), using semi-structured psychiatric interviews, according to the International Classification of Diseases (ICD-10), and the Beck Depression Inventory. RESULTS: Seventeen of 25 patients (68%) had depressive disorder: 6 with dysthymia, three with major depressive episodes and 8 with recurrent depressive disorders. Two (8%) were diagnosed with mixed anxiety and depression. Only 5 of 17 patients (29.4%) were previously diagnosed with depressive disorder and received prior antidepressant treatment. Duration of epilepsy was significantly higher in patients with depressive disorder (p=0.016), but there was no relationship between depression and seizure frequency. CONCLUSION: This study confirmed that depressive disorders are common and underdiagnosed in patients with TLE refractory to AEDs. Patients with longer duration of epilepsy are at higher risk of having depression.<\/jats:p>","DOI":"10.1590\/s0004-282x2011000600010","type":"journal-article","created":{"date-parts":[[2011,10,29]],"date-time":"2011-10-29T04:12:11Z","timestamp":1319861531000},"page":"775-777","source":"Crossref","is-referenced-by-count":15,"title":["Depression in patients with refractory temporal lobe epilepsy"],"prefix":"10.1590","volume":"69","author":[{"given":"Eleonora Borges","family":"Gon\u00e7alves","sequence":"first","affiliation":[{"name":"University of Campinas,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Cendes","sequence":"additional","affiliation":[{"name":"University of Campinas,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1097\/01.wco.0000162853.29650.ec","article-title":"Diagnosis and treatment of mood disordes in 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