{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T12:08:36Z","timestamp":1752667716306},"reference-count":21,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:p>OBJECTIVE: To describe the epidemiological and clinical characteristics of Venezuelan pediatric patients with multiple sclerosis (MS). METHODS: Database records from the National Program for MS were searched for patients with an established diagnosis of MS whose first symptoms appeared before age 18. RESULTS: The national database held records of 1.710 patients; 3.8% had onset of the first symptoms before age 18. 46.7% were boys, yielding an F:M ratio of 1.13:1. Many children had a disease onset characterized by motor impairment (30.7%), brainstem\/cerebellum and spinal cord affectation (27.6%), headache (26%). Less frequent symptoms were sensory symptoms (8%) and optic neuritis (7%). DISCUSSION: Pediatric MS patients in Venezuela represent a significant proportion of all MS cases. The clinical pattern is characterized by motor symptoms at onset, and predominantly monosymptomatic presentation with a relapsing-remitting pattern. This is the first systematic attempt to estimate the prevalence of pediatric MS in Venezuela.<\/jats:p>","DOI":"10.1590\/s0004-282x2012000400008","type":"journal-article","created":{"date-parts":[[2017,3,31]],"date-time":"2017-03-31T14:11:47Z","timestamp":1490969507000},"page":"267-270","source":"Crossref","is-referenced-by-count":5,"title":["Pediatric multiple sclerosis in Venezuela"],"prefix":"10.1590","volume":"70","author":[{"given":"Joaqu\u00edn A.","family":"Pe\u00f1a","sequence":"first","affiliation":[{"name":"University of Zulia,  Venezuela"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Elena","family":"Ravelo","sequence":"additional","affiliation":[{"name":"JM de los Rios Pediatric Hospital,  Venezuela"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelio","family":"Rubio","sequence":"additional","affiliation":[{"name":"Venezuelan Institute of Social Security,  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