{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T13:46:24Z","timestamp":1648647984454},"reference-count":19,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Sa\u00fade P\u00fablica"],"published-print":{"date-parts":[[1983,8]]},"abstract":"<jats:p>Em abril de 1978 uma infec\u00e7\u00e3o mal\u00e1rica causada por Plasinodium falciparum foi diagnosticada em um paciente adulto do sexo masculino, nativo da Amaz\u00f4nia brasileira. O parasito foi resistente in vitro \u00e0 cloroquina e in vivo \u00e0 associa\u00e7\u00e3o pirimetamina + sulfadoxina (FansidarR). O paciente foi tratado com minociclina (MinomaxR); contudo, sua resposta imune ao parasito pode ter tido um importante papel na efic\u00e1cia do tratamento com a minociclina.<\/jats:p>","DOI":"10.1590\/s0034-89101983000400007","type":"journal-article","created":{"date-parts":[[2006,1,9]],"date-time":"2006-01-09T17:41:17Z","timestamp":1136828477000},"page":"328-331","source":"Crossref","is-referenced-by-count":1,"title":["Mal\u00e1ria falciparum resistente \u00e0 cloroquina e ao Fansidar R tratada com minociclina"],"prefix":"10.1590","volume":"17","author":[{"given":"Jos\u00e9 J.","family":"Ferraroni","sequence":"first","affiliation":[{"name":"Instituto Nacional de Pesquisas da Amaz\u00f4nia, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","first-page":"243","article-title":"Treatment of drug-resistant malaria in man","volume":"50","author":"CLYDE D.F.","year":"1974","journal-title":"Bull. 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