{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T00:02:01Z","timestamp":1696982521712},"reference-count":15,"publisher":"FapUNIFESP (SciELO)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Sa\u00fade P\u00fablica"],"published-print":{"date-parts":[[1986,10]]},"abstract":"<jats:p>Realizou-se estudo sobre o desenvolvimento da esquistossomose mans\u00f4nica em camundongos submetidos \u00e0 dieta hipoprot\u00e9ica. Foram constitu\u00eddos 4 grupos de Mus musculus \"Swiss\" da seguinte forma: 1) n\u00e3o infectados, normoprot\u00e9icos; 2) infectados, normoprot\u00e9icos; 3) n\u00e3o infectados, hipoprot\u00e9icos e 4) infectados, hipoprot\u00e9icos. Os animais foram sacrificados com 60 dias de infec\u00e7\u00e3o, aos 90 dias de idade. Verificou-se que os esquistossomos sofreram os efeitos da subnutri\u00e7\u00e3o do hospedeiro, principalmente os vermes machos, que al\u00e9m de terem seu desenvolvimento prejudicado, tiveram seu n\u00famero reduzido aproximadamente pela metade. O n\u00famero de granulomas foi menor nos roedores subnutridos e o tamanho da les\u00e3o foi reduzido. Houve acentuada leucopenia nos animais submetidos \u00e0 dieta hipoprot\u00e9ica, principalmente nos infectados subnutridos. A linfopenia e a eosinopenia acentuadas sugeriram que o sistema imunol\u00f3gico do hospedeiro foi afetado pela subnutri\u00e7\u00e3o. A taxa de mortalidade foi muito mais elevada nos animais infectados submetidos \u00e0 dieta hipoprot\u00e9ica. Concluiu-se que os camundongos subnutridos resistiram menos \u00e0 infec\u00e7\u00e3o esquistossom\u00f3tica apesar de terem apresentado menor n\u00famero de les\u00f5es granulomatosas.<\/jats:p>","DOI":"10.1590\/s0034-89101986000500005","type":"journal-article","created":{"date-parts":[[2006,1,9]],"date-time":"2006-01-09T18:51:01Z","timestamp":1136832661000},"page":"362-368","source":"Crossref","is-referenced-by-count":7,"title":["Esquistossomose mans\u00f4nica em camundongos experimentalmente subnutridos"],"prefix":"10.1590","volume":"20","author":[{"given":"Luiz Augusto","family":"Magalh\u00e3es","sequence":"first","affiliation":[{"name":"Universidade Estadual de Campinas,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Maria A.","family":"Guaraldo","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliana M.","family":"Zanotti-Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 F. de","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valdomiro C.","family":"Sgarbieri","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco G. de","family":"Alc\u00e2ntara","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/0035-9203(81)90117-6","article-title":"Supression of granuloma formation around Schistosoma mansoni eggs in severe protein malnutrition: the role of the egg","volume":"75","author":"AKPOM C.A.","year":"1981","journal-title":"Trans.roy Soc.trop. Med.Hyg."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1093\/infdis\/132.1.6","article-title":"Calorie and protein malnutrition in chronic murine schistosomiasis mansoni, effect on the parasite and the host","volume":"123","author":"AKPOM C.A.","year":"1975","journal-title":"J.infect.Dis."},{"key":"ref3","first-page":"435","article-title":"The inhibition of granuloma formation around Schistosoma mansoni eggs: VI - Protein calorie and vitamin deficiency","volume":"79","author":"AKPOM C.A.","year":"1975","journal-title":"Amer.J.Pathol."},{"key":"ref4","first-page":"583","article-title":"Terap\u00eautica experimental da esquistossomose mansoni: aplica\u00e7\u00e3o do m\u00e9todo de isolamento de granulomas do f\u00edgado de camundongos","volume":"8","author":"BRENER Z.","year":"1956","journal-title":"Rev.bras.Malar."},{"issue":"3\/4","key":"ref5","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1590\/S0074-02761980000200007","article-title":"Patobiologia da desnutri\u00e7\u00e3o nas doen\u00e7as parasit\u00e1rias","volume":"75","author":"COUTINHO E.","year":"1980","journal-title":"Mem.Inst.Oswaldo Cruz"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1590\/S0037-86821972000400007","article-title":"Inqu\u00e9rito cl\u00ednico-nutricional e antropom\u00e9trico preliminar, em \u00e1reas end\u00eamicas de esquistossomose mans\u00f4nica, no Nordeste do Brasil","volume":"6","author":"COUTINHO E.","year":"1972","journal-title":"Rev.Soc.bras.Med.trop."},{"key":"ref7","first-page":"311","article-title":"Les\u00f5es hep\u00e1ticas no camundongo albino experimentalmente infestado por Schistosoma mansoni e submetido a dietas de diferente teor prot\u00e9ico","volume":"4","author":"COUTINHO-ABATH E.","year":"1962","journal-title":"Rev.Inst.Med.trop.S.Paulo"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"119","DOI":"10.2307\/3274635","article-title":"Experimental schistosomiasis mansoni in mice maintained on nutritionally deficient diets: I. 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