{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T03:31:35Z","timestamp":1649215895193},"reference-count":13,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Inst. Med. trop. S. Paulo"],"published-print":{"date-parts":[[1985,8]]},"abstract":"<jats:p>Com o objetivo de testar a viabilidade do ciclo biol\u00f3gico, 15 pacientes (masculinos, de quatro a 14 anos) com Ascaris lumbricoides, foram selecionados ao acaso. Ap\u00f3s tratamento cl\u00e1ssico com sais b\u00e1sicos de levamisole (7 pacientes) e de pamoato de pirantel (8), os ovos retirados das f\u00eameas expelidas ficaram incubados por 18 dias em de H2SO4 N\/10. A seguir foram administrados per os a grupos de 5 camundongos por pacientes. Decorridos 8 dias da infec\u00e7\u00e3o, os animais foram sacrificados para pesquisas microsc\u00f3pica de larvas nos fragmentos pulmonares. Dos 75 animais, somente 1, pertencente ao grupo de tratados com levamisole, n\u00e3o apresentou larvas nos fragmentos pulmonares. Concluiu-se que as drogas, nas doses utilizadas, n\u00e3o possuem a\u00e7\u00e3o delet\u00e9ria sobre os ovos de A. lumbricoides, mas promovem a elimina\u00e7\u00e3o de material infectivo, com possibilidade de incrementar a polui\u00e7\u00e3o onde vivem comunidades sem adequadas condi\u00e7\u00f5es de saneamento b\u00e1sico.<\/jats:p>","DOI":"10.1590\/s0036-46651985000400007","type":"journal-article","created":{"date-parts":[[2012,10,27]],"date-time":"2012-10-27T05:57:24Z","timestamp":1351317444000},"page":"197-200","source":"Crossref","is-referenced-by-count":4,"title":["Viabilidade de ovos de Ascaris lumbricoides ap\u00f3s tratamento humano com medicamentos espec\u00edficos: I\u2014 Levamisole e Pamoato de pirantel"],"prefix":"10.1590","volume":"27","author":[{"given":"Maria Suzana de Lemos","family":"Souza","sequence":"first","affiliation":[{"name":"UFMG"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirceu Wagner Carvalho de","family":"Souza","sequence":"additional","affiliation":[{"name":"UFMG"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar dos Santos","family":"Carvalho","sequence":"additional","affiliation":[{"name":"FIOCRUZ"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayme","family":"Neves","sequence":"additional","affiliation":[{"name":"UFMG"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiano Lara","family":"Massara","sequence":"additional","affiliation":[{"name":"FIOCRUZ"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1590\/S0037-86821974000400007","article-title":"Ecologia, infec\u00e7\u00e3o e doen\u00e7a","volume":"8","author":"AVILA-PIRES F. 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