{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T11:42:56Z","timestamp":1768822976286,"version":"3.49.0"},"reference-count":32,"publisher":"FapUNIFESP (SciELO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Inst. Med. trop. S. Paulo"],"published-print":{"date-parts":[[1986,6]]},"abstract":"<jats:p>A double-blind clinical trial involving 120 patients with chronic schistosomiasis was carried out to compare the tolerability and efficacy of praziquantel and oxamniquine. The patients were randomly allocated into two groups. One was treated with praziquantel, 55 mg\/kg of body weight CBWT), and the other one with oxamniquine, 15mg\/kg bwt, administered in a single oral dose. The diagnosis and the parasitological follow-up was based on stool examinations by quantitative Kato-Katz method and on rectal biopsies. Side-effects \u2014 mainly dizziness, sleepness, abdominal distress, headache, nausea and diarrhea \u2014 were observed in 87% of the cases. Their incidence, intensity and duration were similar for both drugs but abdominal pain was significantly more frequent after praziquantel intake and severe dizziness was more commonly reported after oxamniquine. A significant increase of alanine-aminotransferase and y-glutamyltransferase was found with the latter drug and of total bilirubin with the former one. A total of 48 patients treated with praziquantel and 46 with oxamniquine completed with negative findings the required three post-treatment parasitological controls \u2014 three slides of each stool sample on the first, third and sixth month. The achieved cure rates were 79.2% and 84.8%, respectively, a difference without statistical significance. The non-cured cases showed a mean reduction in the number of eggs per gram of feces of 93.5% after praziquantel and of 84.1% after oxamniquine. This diference also was not significant. Five patients retreated with praziquantel were cured but only one out of three treated a second time with oxamniquine. These findings show that both drugs \u2014 despite their different chemical structures, pharmacological properties and mechanisms-of-action \u2014 induce similar side-effects as well as a comparable therapeutical efficacy, in agreement with the results reported from analogous investigations.<\/jats:p>","DOI":"10.1590\/s0036-46651986000300007","type":"journal-article","created":{"date-parts":[[2012,10,17]],"date-time":"2012-10-17T09:53:11Z","timestamp":1350467591000},"page":"174-180","source":"Crossref","is-referenced-by-count":18,"title":["Treatment of patients with Schistosomiasis mansoni: a double blind clinical trial comparing praziquantel with oxamniquine"],"prefix":"10.1590","volume":"28","author":[{"given":"Luiz Caetano da","family":"Silva","sequence":"first","affiliation":[{"name":"Instituto de Medicina Tropical de S\u00e3o Paulo, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Murilo R.","family":"Zeitune","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Tropical de S\u00e3o Paulo, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia Maria F.","family":"Rosa-Eid","sequence":"additional","affiliation":[{"name":"Inst. Med. Tropical S. Paulo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirce Mary C.","family":"Lima","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Tropical de S\u00e3o Paulo, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita H.","family":"Antonelli","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Tropical de S\u00e3o Paulo, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos H.","family":"Christo","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Tropical de S\u00e3o Paulo, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amadeo","family":"Saez-Alquezar","sequence":"additional","affiliation":[{"name":"U.S.P."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriany de Castro","family":"Carboni","sequence":"additional","affiliation":[{"name":"U.S.P."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"890","DOI":"10.4269\/ajtmh.1980.29.890","article-title":"Susceptibility to chemoterapeutic agents of strains of Schistosoma mansoni isolated from treated and untreated patients","volume":"29","author":"ARAUJO N.","year":"1980","journal-title":"Amer. J. trop. Med. Hyg.","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9637","issn-type":"print"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1590\/S0037-86821976000400006","article-title":"Convuls\u00e3o associada ao uso da oxaminiquine: Relato de um caso","volume":"10","author":"BINA J. C.","year":"1976","journal-title":"Rev. Soc. bras. Med. trop.","ISSN":"https:\/\/id.crossref.org\/issn\/0037-8682","issn-type":"print"},{"key":"ref3","first-page":"315","article-title":"Double-blind clinical trial comparing praziquantel with oxamniquine in the treatment of patients with schistosomiasis mansoni","volume":"24","author":"BRANCHINI M. L. M.","year":"1982","journal-title":"Rev. Inst. Med. trop. S. Paulo","ISSN":"https:\/\/id.crossref.org\/issn\/0036-4665","issn-type":"print"},{"key":"ref4","first-page":"171","article-title":"Experi\u00eancia com hycanthone em 3.100 portadores de esquistossomose mans\u00f4nica","volume":"22","author":"BUAIS V.","year":"1976","journal-title":"Rev. Ass. med. bras."},{"key":"ref5","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0035-9203(76)90061-4","article-title":"Hycanthone resistance in a human strain of Schistosoma mansoni","volume":"70","author":"CAMPOS R.","year":"1973","journal-title":"Trans, roy. Soc. trop. Med. Hyg."},{"key":"ref6","first-page":"27","article-title":"Tratamento da esquistossomose mans\u00f4nica: aspectos atuais","volume":"23","author":"COUTINHO A.","year":"1977","journal-title":"Rev. Ass. med. bras."},{"key":"ref7","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1590\/S0036-46651984000100007","article-title":"Tratamento da esquistossomose mans\u00f4nica hepatespl\u00eanica com praziquantel","volume":"26","author":"COUTINHO. A. D.","year":"1984","journal-title":"Rev. Inst. Med. trop. S. Paulo","ISSN":"https:\/\/id.crossref.org\/issn\/0036-4665","issn-type":"print"},{"key":"ref8","first-page":"88","article-title":"A avalia\u00e7\u00e3o terap\u00eautica da oxaminiquine na esquistossomose mansoni humana pelo m\u00e9todo do oograma por bi\u00f3psia da mucosa retal","volume":"24","author":"CUNHA A. S- da","year":"1982","journal-title":"Rev. Inst. Med. trop. S. Paulo","ISSN":"https:\/\/id.crossref.org\/issn\/0036-4665","issn-type":"print"},{"key":"ref9","series-title":"Schistosomiasis: Epidemiology, treatment and control","first-page":"184","volume-title":"Management of the patient with schistosomiasis","author":"DAVIS A.","year":"1982"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1590\/S0034-89101978000100013","article-title":"Linhagem humana de schistosoma mansoni resistente a esquistossomicidas","volume":"12","author":"DIAS L. C. de S.","year":"1978","journal-title":"Rev. Sa\u00fade p\u00fabl.","ISSN":"https:\/\/id.crossref.org\/issn\/0034-8910","issn-type":"print"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/0035-9203(82)90235-8","article-title":"Use of praziquantel in patients with schistosomiasis mansoni previously treated with oxamniquine and\/or hycanthone: resistance of Schistosoma mansoni to schistosomicidai agents","volume":"76","author":"DIAS L. C. de S.","year":"1982","journal-title":"Trans. roy. Soc. trop. Med. Hyg.","ISSN":"https:\/\/id.crossref.org\/issn\/0035-9203","issn-type":"print"},{"key":"ref12","first-page":"178","article-title":"Praziquantel no tratamento da esquistossomose mansoni em crian\u00e7as","volume":"25","author":"EMANUEL A.","year":"1983","journal-title":"Rev. Inst. Med. trop. S. Paulo","ISSN":"https:\/\/id.crossref.org\/issn\/0036-4665","issn-type":"print"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1590\/S0037-86821983000200005","article-title":"Compara\u00e7\u00e3o entrepraziquantel e oxamniquine no tratamento da esquistossomose mansoni","volume":"16","author":"EMANUEL A.","year":"1983","journal-title":"Rev. Soc. bras. Med. trop.","ISSN":"https:\/\/id.crossref.org\/issn\/0037-8682","issn-type":"print"},{"key":"ref14","series-title":"The analysis of contingency tables","author":"EVERITT B. S.","year":"1977"},{"key":"ref15","first-page":"555","article-title":"Toxicological profile of praziquantel, a new drug against cestode and schistosome infections, as compared tosome other schistosomicides: Arxneim","volume":"31","author":"FROHBERG H.","year":"1981","journal-title":"For sen.\/Drug Res."},{"key":"ref16","first-page":"48","article-title":"Resist\u00eancia ao hycanthone e oxamniquine em doentes com esquistossomose forma cl\u00ednica hepatintestinal","volume":"25","author":"GUIMAR\u00c3ES R. X.","year":"1979","journal-title":"Rev. Ass. m\u00e9d. bras."},{"key":"ref17","first-page":"397","article-title":"A simple device for quantitative stool thick-smear technique in schistosomiasis mansoni","volume":"14","author":"KATZ N.","year":"1972","journal-title":"Rev. Inst. Med. trop. S. 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Paulo","ISSN":"https:\/\/id.crossref.org\/issn\/0036-4665","issn-type":"print"},{"key":"ref21","first-page":"173","article-title":"Clinical trial with oxamniquine and praziquantel in the acute and chronic phases of schistosomiasis mansoni","volume":"25","author":"KATZ N.","year":"1983","journal-title":"Rev. Inst. Med. trop. S. Paulo","ISSN":"https:\/\/id.crossref.org\/issn\/0036-4665","issn-type":"print"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.4269\/ajtmh.1981.30.1219","article-title":"Treatment of schistosomiasis mansoni with oxamniquine \u2014 five years' experience","volume":"30","author":"KILPATRICK M. E.","year":"1981","journal-title":"Amer. J. trop. Med. Hyg.","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9637","issn-type":"print"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/0035-9203(82)90098-0","article-title":"A double-blind trial with oxamniquine in chronic schistosomiasis mansoni","volume":"76","author":"LAMBERTUCCI J. R.","year":"1982","journal-title":"Trans. roy. Soc. trop. Med. Hyg.","ISSN":"https:\/\/id.crossref.org\/issn\/0035-9203","issn-type":"print"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1136\/bmj.2.6202.1396","article-title":"Praziquantel: a new schistosomicide against Schistosome haematobium","volume":"2","author":"McMAHON J. E.","year":"1979","journal-title":"Brit. Med. J.","ISSN":"https:\/\/id.crossref.org\/issn\/0267-0623","issn-type":"print"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"740","DOI":"10.7326\/0003-4819-97-5-740","article-title":"Schistosome infections in humans: perspectives and recent findings","volume":"97","author":"NASH T. E.","year":"1982","journal-title":"Ann. intern. Med.","ISSN":"https:\/\/id.crossref.org\/issn\/0003-4819","issn-type":"print"},{"key":"ref26","first-page":"95","article-title":"Praziquantel no tratamento da esquistossomose mansoni","volume":"24","author":"PRATA A.","year":"1982","journal-title":"Rev. Inst. Med. trop. S. Paulo","ISSN":"https:\/\/id.crossref.org\/issn\/0036-4665","issn-type":"print"},{"key":"ref27","series-title":"N\u00edveis plasm\u00e1ticos de atividade enzim\u00e1tica da alanina aminotransferase, guanase e fosfatase alcalina em camundongos infestados por Schistosom mansoni e tratados com oxamniquina","author":"SA\u00c9Z-ALQUEZAR A.","year":"1980"},{"key":"ref28","first-page":"307","article-title":"Further clinical trials with oxamniquine (UK 4271), a new anti-schistosomal agent","volume":"17","author":"SILVA L. C. da","year":"1975","journal-title":"Rev. Inst. Med. trop. S. Paulo","ISSN":"https:\/\/id.crossref.org\/issn\/0036-4665","issn-type":"print"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/0016-5085(78)93084-6","article-title":"Resistance of Schistosoma mansoni to chemotherapy in human cases","volume":"74","author":"SILVA L. C. da","year":"1978","journal-title":"Gastroenterology","ISSN":"https:\/\/id.crossref.org\/issn\/0016-5085","issn-type":"print"},{"key":"ref30","first-page":"601","article-title":"Praziquantel in treatment of the hepatosplenic form of schistosomiasis mansoni","volume":"31","author":"SILVA L. C. da","year":"1981","journal-title":"Arzneim. Forsch.\/Drug Res."},{"key":"ref31","series-title":"Multivariate analysis with applications in education and psychology","author":"TIMM N. H.","year":"1975"},{"key":"ref32","first-page":"375","article-title":"Clinical evaluation of praziquantel in treatment of schistosomiasis japonica: A repot of 181 cases","volume":"93","year":"1980","journal-title":"Clin. m\u00e9d. J."}],"container-title":["Revista do Instituto de Medicina Tropical de S\u00e3o Paulo"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/rimtsp\/v28n3\/07.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T18:50:29Z","timestamp":1562266229000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0036-46651986000300007&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,6]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1986,6]]}},"alternative-id":["S0036-46651986000300007"],"URL":"https:\/\/doi.org\/10.1590\/s0036-46651986000300007","relation":{},"ISSN":["0036-4665"],"issn-type":[{"value":"0036-4665","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,6]]}}}