{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:57:16Z","timestamp":1791284236604,"version":"4.1.0"},"reference-count":36,"publisher":"FapUNIFESP (SciELO)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Inst. Med. trop. S. Paulo"],"published-print":{"date-parts":[[1997,3]]},"abstract":"<jats:p>A strain of Schistosoma mansoni (R1) was isolated from patient previously submitted to four treatments with oxamniquine, and to another one with praziquantel. The results obtained with chemotherapeutic test, by using oxamniquine in mice infected with the strains R1 and LE (standard), showed an evident resistance to the drug in worms of the strain R1. Thus, at the dose of 250 mg\/kg oxamniquine, all mice (17) infected with the LE strain did not show surviving worms, whereas 12 out of 17 mice infected with the R1 strain presented surviving worms. At the dose of 200 mg\/kg, the LE strain showed recovery rates of 1.06% and 20.58%, whereas the R1 strain presented 18.57% and 61.14%, for male and female worms, respectively. At the dose of 100 mg\/kg, the recovery of male worms was 2.6% for the LE strain, and 29.9% for the R1 strain. At the same dose, the recovery of females did not show statistically significant differences between the two strains (LE = 76.38%, R1 = 79.12%). Praziquantel showed similar antischistosomal activity against both studied strains, when administered at the dose of 500 mg\/kg<\/jats:p>","DOI":"10.1590\/s0036-46651997000200007","type":"journal-article","created":{"date-parts":[[2005,5,9]],"date-time":"2005-05-09T14:13:53Z","timestamp":1115648033000},"page":"101-106","source":"Crossref","is-referenced-by-count":16,"title":["RESISTANCE TO OXAMNIQUINE OF A Schistosoma mansoni STRAIN ISOLATED FROM PATIENT SUBMITTED TO REPEATED TREATMENTS"],"prefix":"10.1590","volume":"39","author":[{"given":"M.Z.","family":"COELHO","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.C.","family":"LIMA E SILVA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.A.","family":"NOGUEIRA-MACHADO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"890","DOI":"10.4269\/ajtmh.1980.29.890","article-title":"Susceptibility to chemotherapeutic agents of strains of Schistosoma mansoni isolated from treated and untreated patients","volume":"29","author":"ARA\u00daJO N.","year":"1980","journal-title":"Amer. J. trop. Med. Hyg.","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9637","issn-type":"print"},{"key":"ref2","author":"ARA\u00daJO N.","year":"1995"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0166-6851(90)90133-7","article-title":"Mode of action of the schistosomicide hycanthone: site of DNA alkylation","volume":"43","author":"ARCHER S.","year":"1990","journal-title":"Molec. Biochem. Parasit","ISSN":"https:\/\/id.crossref.org\/issn\/0166-6851","issn-type":"print"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1017\/S0031182000051027","article-title":"Resistance following drug attenuation (Ro-11.3128 or oxamniquine) of early Schistosoma mansoni infections in mice","volume":"90","author":"BICKLE Q.D.","year":"1985","journal-title":"Parasitology","ISSN":"https:\/\/id.crossref.org\/issn\/0031-1820","issn-type":"print"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"7754","DOI":"10.1073\/pnas.88.17.7754","article-title":"Characterization of a programmed alteration in an l85 ribosomal gene that accompanies the experimental induction of drug resistance in Schistosoma mansoni","volume":"88","author":"BRINDLEY P.J.","year":"1991","journal-title":"Proc. nat. Acad. Sci. (Wash.)","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0166-6851(89)90172-2","article-title":"A genomic change associated with development of resistance to hycanthone in Schistosoma mansoni","volume":"36","author":"BRINDLEY P.J.","year":"1989","journal-title":"Molec. Biochem. Parasit","ISSN":"https:\/\/id.crossref.org\/issn\/0166-6851","issn-type":"print"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0035-9203(76)90061-4","article-title":"Hycanthone resistance in a human strain of Schistosoma mansoni","volume":"70","author":"CAMPOS R","year":"1976","journal-title":"Trans. roy. Soc. trop. Med. Hyg","ISSN":"https:\/\/id.crossref.org\/issn\/0035-9203","issn-type":"print"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/0169-4758(93)90138-6","article-title":"Drug resistance in schistosomes","volume":"9","author":"CIOLI D","year":"1993","journal-title":"Parasit. today","ISSN":"https:\/\/id.crossref.org\/issn\/0169-4758","issn-type":"print"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0163-7258(95)00026-7","article-title":"Antischistosomal drugs. Past, present... and future?","volume":"68","author":"CIOLI D.","year":"1995","journal-title":"Pharmacol. Therap","ISSN":"https:\/\/id.crossref.org\/issn\/0163-7258","issn-type":"print"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/0014-4894(92)90255-9","article-title":"Hycanthone\/oxamniquine resistance is controlled by a single autosomal recessive gene","volume":"75","author":"CIOLI D.","year":"1992","journal-title":"Exp. Parasit","ISSN":"https:\/\/id.crossref.org\/issn\/0014-4894","issn-type":"print"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1590\/S0036-46651991000100010","article-title":"Schistosoma mansoni: preclinical studies with 9-Acridanone-hydrazones in Cebus monkeys experimentally infected","volume":"33","author":"COELHO P.M.Z.","year":"1991","journal-title":"Rev. Inst. Med. trop. S. Paulo","ISSN":"https:\/\/id.crossref.org\/issn\/0036-4665","issn-type":"print"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1590\/S0037-86821995000300003","article-title":"Antischistosomal activity of acridanone-hydrazones in Cebus monkeys experimentally infected with the SJ strain of Schistosoma mansoni","volume":"28","author":"COELHO P.M.Z.","year":"1995","journal-title":"Rev. Soc. bras. Med. trop.","ISSN":"https:\/\/id.crossref.org\/issn\/0037-8682","issn-type":"print"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/0035-9203(87)90032-0","article-title":"Tolerance of Kenyan Schistosoma mansoni to oxamniquine","volume":"81","author":"COLES G.C.","year":"1987","journal-title":"Trans. roy. Soc. trop. Med. Hyg.","ISSN":"https:\/\/id.crossref.org\/issn\/0035-9203","issn-type":"print"},{"key":"ref14","series-title":"Practical nonparametric statistics","author":"CONOVER W.J.","year":"1980"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1590\/S0036-46651988000200005","article-title":"Variations in response of Schistosoma mansoni strains to schistosomicides","volume":"30","author":"DIAS L.C.S.","year":"1988","journal-title":"Rev. Inst. Med. trop. S. Paulo","ISSN":"https:\/\/id.crossref.org\/issn\/0036-4665","issn-type":"print"},{"key":"ref16","first-page":"652\u2014659","article-title":"Use of praziquantel in patients with schistosomiasis previously treated with oxamniquine and\/or hycanthone: resistance of Schistosoma mansoni schistosomicidal agents","volume":"76","author":"DIAS L.C.S.","year":"1982","journal-title":"Trans. roy. Soc. trop. Med. Hyg","ISSN":"https:\/\/id.crossref.org\/issn\/0035-9203","issn-type":"print"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1590\/S0034-89101978000100013","article-title":"Linhagem humana de Schistosoma mansoni resistente a esquistossomicidas","volume":"12","author":"DIAS L.C.S.","year":"1978","journal-title":"Rev. Sa\u00fade p\u00fabl. (S. Paulo)","ISSN":"https:\/\/id.crossref.org\/issn\/0034-8910","issn-type":"print"},{"key":"ref18","first-page":"459","article-title":"Enzymatic differences between hycanthone-resistant and sensitive strains of Schistosoma mansoni","volume":"87B","author":"DOONG Y.C.","year":"1987","journal-title":"Comp. Biochem. Physiol","ISSN":"https:\/\/id.crossref.org\/issn\/0010-406X","issn-type":"print"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1590\/S0074-02761993000100014","article-title":"Response of drug resistant isolates of Schistosoma mansoni to antischistosomal agents","volume":"88","author":"DRESCHER K.C.","year":"1993","journal-title":"Mem. Inst. Oswaldo Cruz","ISSN":"https:\/\/id.crossref.org\/issn\/0074-0276","issn-type":"print"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"83","DOI":"10.4269\/ajtmh.1994.51.83","article-title":"Drug resistant schistosomiasis: resistance to praziquantel and oxamniquine induced in Schistosoma mansoni in mice is drug specific","volume":"51","author":"FALLON P.G.","year":"1994","journal-title":"Amer. J. trop. Med. Hyg.","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9637","issn-type":"print"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"61","DOI":"10.4269\/ajtmh.1995.53.61","article-title":"Diminished susceptibility to praziquantel in a Senegal isolate of Schistosoma manson","volume":"53","author":"FALLON P.G.","year":"1995","journal-title":"Amer. J. trop. Med. Hyg","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9637","issn-type":"print"},{"key":"ref22","first-page":"48","article-title":"Resist\u00eancia ao hycanthone e oxamniquine em doentes com esquistossomose com a forma cl\u00ednica hepato-intestinal","volume":"25","author":"GUIMAR\u00c3ES R.X","year":"1979","journal-title":"Rev. Ass. m\u00e9d. bras","ISSN":"https:\/\/id.crossref.org\/issn\/0104-4230","issn-type":"print"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"827","DOI":"10.4269\/ajtmh.1975.24.827","article-title":"Anticholinergic properties of the antischistosomal drug hycanthone","volume":"24","author":"HILLMAN G.R.","year":"1975","journal-title":"Amer. J. trop. Med. Hyg","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9637","issn-type":"print"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"754","DOI":"10.2307\/3279978","article-title":"The mode of action of hycanthone revised","volume":"64","author":"HILLMAN G.R.","year":"1978","journal-title":"J. Parasit","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3395","issn-type":"print"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"926","DOI":"10.4269\/ajtmh.1977.26.926","article-title":"Experimentally produced resistance of Schistosoma mansoni to hycanthone","volume":"26","author":"JANSMA W.B.","year":"1977","journal-title":"Amer. J. trop. Med. Hyg","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9637","issn-type":"print"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1590\/S0037-86821973000600008","article-title":"Estudo de uma cepa humana de Schistosoma mansoni resistente a agentes esquistossomicidas","volume":"6","author":"KATZ N.","year":"1973","journal-title":"Rev. Soc. bras. Med. trop","ISSN":"https:\/\/id.crossref.org\/issn\/0037-8682","issn-type":"print"},{"key":"ref27","first-page":"32","article-title":"Observations on the treatment of mansoni schistosomiasis with oxamniquine: efficacy in children and in persistent salmonellosis; resistance of a strain of Schistosoma mansoni; hepatotoxicity and neurological side effects","volume":"22","author":"PEDRO R.J.","year":"1980","journal-title":"Rev. Inst. Med. trop. S. Paulo","ISSN":"https:\/\/id.crossref.org\/issn\/0036-4665","issn-type":"print"},{"key":"ref28","first-page":"589","article-title":"T\u00e9cnica de perfus\u00e3o para colheita de Schistosoma mansoni de cobaias experimentalmente infestadas","volume":"3","author":"PELLEGRINO J.","year":"1956","journal-title":"Rev. bras. Malar"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1590\/S0074-02761995000300021","article-title":"Activity of 9-Acridanone-hydrazone drugs detected as the pre-postural phase, in the experimental schistosomiasis mansoni","volume":"90","author":"PEREIRA L.H.","year":"1995","journal-title":"Mem. Inst. Oswaldo Cruz","ISSN":"https:\/\/id.crossref.org\/issn\/0074-0276","issn-type":"print"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0035-9203(89)90508-7","article-title":"Binding of oxamniquine to the DNA of schistosomes","volume":"83","author":"PICA-MATTOCCIA L.","year":"1989","journal-title":"Trans. roy. Soc. trop. Med. Hyg.","ISSN":"https:\/\/id.crossref.org\/issn\/0035-9203","issn-type":"print"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1006\/expr.1993.1104","article-title":"Schistosoma mansoni genetic complementation analysis shows that two independ hycanthone\/oxamniquine-resistant strains are mutated in the same gene","volume":"77","author":"PICA-MATTOCCIA L.","year":"1993","journal-title":"Exp. Parasit","ISSN":"https:\/\/id.crossref.org\/issn\/0014-4894","issn-type":"print"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1126\/science.172.3987.1057","article-title":"Hycanthone resistance: development in Schistosoma manson","volume":"172","author":"ROGERS S.H.","year":"1971","journal-title":"Science","ISSN":"https:\/\/id.crossref.org\/issn\/0036-8075","issn-type":"print"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"167","DOI":"10.4269\/ajtmh.1995.53.167","article-title":"Low efficacy and tolerance of praziquantel in a new intense focus of Schistosoma mansoni","volume":"53","author":"STELMA F.F.","year":"1995","journal-title":"Amer. J. trop. Med. Hyg.","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9637","issn-type":"print"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/0035-9203(87)90210-0","article-title":"Parasitological evaluation of curative and subcurative doses of 9-acridanone-hydrazone drugs against Schistosoma mansoni in baboons, and observations on the changes in serum levels of anti-egg antibodies detected by ELISA","volume":"81","author":"STURROCK R.F.","year":"1987","journal-title":"Trans. roy. Soc. trop. Med. Hyg.","ISSN":"https:\/\/id.crossref.org\/issn\/0035-9203","issn-type":"print"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0035-9203(85)90256-1","article-title":"A note on the efficacy of a new class of compounds, 9-acridanone-hydrazones, against Schistosoma mansoni in a primate - the baboon","volume":"79","author":"STURROCK R.F.","year":"1985","journal-title":"Trans. roy. Soc. trop. Med. Hyg","ISSN":"https:\/\/id.crossref.org\/issn\/0035-9203","issn-type":"print"},{"key":"ref36","first-page":"335","article-title":"Efficacy of a new Hoffmann-La Roche compound (Ro-155458) against Schistosoma mansoni (Gezira strain, Sudan) in vervet monkeys (Cercopithecus aethiops)","volume":"40","author":"SULAIMAN S.M.","year":"1989","journal-title":"Trop. Med. Parasit","ISSN":"https:\/\/id.crossref.org\/issn\/0177-2392","issn-type":"print"}],"container-title":["Revista do Instituto de Medicina Tropical de S\u00e3o Paulo"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/rimtsp\/v39n2\/0019.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,5,17]],"date-time":"2017-05-17T17:04:17Z","timestamp":1495040657000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0036-46651997000200007&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,3]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1997,3]]}},"alternative-id":["S0036-46651997000200007"],"URL":"https:\/\/doi.org\/10.1590\/s0036-46651997000200007","relation":{},"ISSN":["0036-4665"],"issn-type":[{"value":"0036-4665","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,3]]}}}