{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T20:01:30Z","timestamp":1774123290049,"version":"3.50.1"},"reference-count":23,"publisher":"FapUNIFESP (SciELO)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Inst. Med. trop. S. Paulo"],"published-print":{"date-parts":[[1997,11]]},"abstract":"<jats:p>Cryptococcus neoformans is the fifth most common opportunistic agent of infection in patients with AIDS in the USA, exceeded only by Candida species, Pneumocystis carinii, cytomegalovirus and Mycobacterium avium1, 2, 6, 10, 11. In Brazil is the sixth, exceeded by Candida species, P. carinii, Mycobacterium species, Toxoplasma gondii, and herpes simplex virus (AIDS, Boletim Epidemiol\u00f3gico, set\/nov 96, Minist\u00e9rio da Sa\u00fade, Brasil). During 30 years, the treatment of C. neoformans meningitis was based on the use of amphotericin B with or without flucytosine13. Nowadays, with the immunodepression caused by human immunodeficiency virus (HIV) infection and the availability of new antifungal drugs as the triazoles, the concept related to cure and relapses of cryptococcosis has been altered7, 20. Patients are treated with amphotericin B with or without flucytosine as initial therapy, but maintenance therapy is always necessary in AIDS patients with C. neoformans infections<\/jats:p>","DOI":"10.1590\/s0036-46651997000600010","type":"journal-article","created":{"date-parts":[[2005,4,27]],"date-time":"2005-04-27T09:24:39Z","timestamp":1114593879000},"page":"359-362","source":"Crossref","is-referenced-by-count":10,"title":["Development of Secondary Resistance to Fluconazole in Cryptococcus neoformans Isolated from a Patient with AIDS"],"prefix":"10.1590","volume":"39","author":[{"given":"Sydney H.","family":"ALVES","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge O.","family":"LOPES","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane M.","family":"COSTA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00f3vis","family":"KLOCK","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1093\/infdis\/164.2.435","article-title":"Persistence of Cryptococcus neoformans in the prostate: failure of fluconazole despite high doses","volume":"164","author":"BAYLLY M. 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Agents Chemother."},{"key":"ref3","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1111\/j.1699-0463.1968.tb03215.x","article-title":"Development of strains of Cryptococcus neoformans resistant to nystatin, amphotericin B, trichomycin and polymixin B","volume":"73","author":"BODENHOFF J.","year":"1968","journal-title":"Acta path. microb. scand."},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1128\/AAC.37.6.1383","article-title":"Susceptibilities of serial Cryptococcus neoformans isolates from patients with recurrent cryptococcal meningitis to amphotericin B and fluconazole","volume":"37","author":"CASADEVALL A.","year":"1993","journal-title":"Antimicrob. 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H.","year":"1994","journal-title":"J. infect. Dis.","ISSN":"https:\/\/id.crossref.org\/issn\/0022-1899","issn-type":"print"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1128\/AAC.39.7.1526","article-title":"Cross-resistance to polyene and azole drugs in Cryptococcus neoformans","volume":"39","author":"JOSEPH-HORNE T.","year":"1995","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref12","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1080\/02681219680000381","article-title":"Amphotericin B resistant isolates of Cryptococcus neoformans without alteration in sterol biosynthesis","volume":"34","author":"JOSEPH-HORNE T.","year":"1996","journal-title":"J. med. vet. 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