{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T10:06:58Z","timestamp":1686823618930},"reference-count":46,"publisher":"FapUNIFESP (SciELO)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Inst. Med. trop. S. Paulo"],"published-print":{"date-parts":[[1998,9]]},"abstract":"<jats:p>This prospective study on 41 autopsy collected human hearts concerns the \"apical\" lesion in Chagas' disease. Previous report did not show a correlation between lesion frequency and heart weight then discarding a vascular factor in its pathogenesis. The present paper involves other variables besides the heart weight to evaluate the relative coronary insufficiency. Distinct colored gel (green and red) injected through the capillary beds of both coronary arteries defined the extent of both vessels before separating the atria and removing the sub-epicardium fat. The Right Ventricle (RV) and Left Ventricle (LV) free walls furnished the RV\/LV mass ratio. The myocardium mass colored green (right coronary artery - RC) and the whole Ventricular Weight (VW) determined the RC\/VW mass ratio. The heart weight plus these mass ratios, graded and added, composed a score inversely proportional to the myocardium irrigation condition. It intended to be a more sensitive morphologic evaluation of the relative ischaemia to correlate to the apical lesion. This study showed a right deviation for the relative accumulated frequency of lesions plotted as a score function and a significant difference for higher scores in hearts with aneurysm. It suggests a ischaemic factor intervening in the apical lesion pathogenesis in Chagas' cardiopathy.<\/jats:p>","DOI":"10.1590\/s0036-46651998000500007","type":"journal-article","created":{"date-parts":[[2005,4,27]],"date-time":"2005-04-27T13:25:28Z","timestamp":1114608328000},"page":"301-307","source":"Crossref","is-referenced-by-count":11,"title":["HEART ANEURYSM IN CHAGAS' DISEASE"],"prefix":"10.1590","volume":"40","author":[{"given":"Jos\u00e9 Alberto Mello de","family":"OLIVEIRA","sequence":"first","affiliation":[{"name":"University of S\u00e3o Paulo"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","first-page":"23","article-title":"A \"les\u00e3o vorticilar\" na cardiopatia chag\u00e1sica cr\u00f4nica: Aspectos morfol\u00f3gicos","volume":"28","author":"Almeida H.O.","year":"1982","journal-title":"Rev. goiana Med.","ISSN":"http:\/\/id.crossref.org\/issn\/0034-9585","issn-type":"print"},{"key":"ref2","first-page":"129","article-title":"Hip\u00f3xia como fator patogen\u00e9tico da les\u00e3o apical em chag\u00e1sicos cr\u00f4nicos","volume":"32","author":"Almeida H.O.","year":"1986","journal-title":"Rev. goiana Med.","ISSN":"http:\/\/id.crossref.org\/issn\/0034-9585","issn-type":"print"},{"key":"ref3","first-page":"803","article-title":"A les\u00e3o apical do cora\u00e7\u00e3o na miocardite cr\u00f4nica chag\u00e1sica","volume":"50","author":"Andrade Z.A.","year":"1956","journal-title":"Hospital"},{"key":"ref4","first-page":"149","article-title":"A mutabilidade eletrocardiogr\u00e1fica na cardiopatia chag\u00e1sica cr\u00f4nica","volume":"4","author":"Brasil A.","year":"1953","journal-title":"Rev. Ass. m\u00e9d. Minas Gerais"},{"key":"ref5","series-title":"Cardiac pathology","first-page":"51","author":"Bloor C.M.","year":"1978"},{"key":"ref6","first-page":"195","article-title":"Necrotizing arteritis in megaesophagus: Histopathology of ninety-one biopsies taken from the cardia","volume":"1","author":"Brito T.","year":"1959","journal-title":"Rev. Inst. Med. trop. S. Paulo","ISSN":"http:\/\/id.crossref.org\/issn\/0036-4665","issn-type":"print"},{"key":"ref7","series-title":"Patologia general","first-page":"194","volume-title":"Patologia general de la circulaci\u00f3n","author":"B\u00fcchner F.","year":"1964"},{"key":"ref8","first-page":"161","article-title":"Altera\u00e7\u00f5es do complexo QRS nas deriva\u00e7\u00f5es precordiais e seu substrato anat\u00f4mico em pacientes portadores de miocardite chag\u00e1sica cr\u00f4nica","volume":"45","author":"Carvalhal S.","year":"1954","journal-title":"Rev. paul. Med.","ISSN":"http:\/\/id.crossref.org\/issn\/0035-0362","issn-type":"print"},{"key":"ref9","first-page":"425","article-title":"Histologic correlation of ischemic and chagasic ventricular aneurysms: Relation to physiopathology","volume":"58","author":"Castagnino H.E.","year":"1988","journal-title":"Arch. Inst. Cardiol. M\u00e9x."},{"issue":"16","key":"ref10","first-page":"161","article-title":"Nova esp\u00e9cie m\u00f3rbida do homem, produzida por um Trypanosoma (Trypanosoma cruzi): Nota pr\u00e9via","volume":"23","author":"Chagas C.","year":"1909","journal-title":"Brasil-m\u00e9d."},{"key":"ref11","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/0735-1097(95)00262-2","article-title":"High prevalence of antibodies against beta 1- and beta 2-adrenoceptors in patients with primary electrical abnormalities","volume":"26","author":"Chiale P.A.","year":"1995","journal-title":"J. Amer. Coll. Cardiol."},{"key":"ref12","series-title":"The pathology of the heart","first-page":"1","volume-title":"Techniques in examination and anatomy of the heart","author":"Davies M.J.","year":"1975"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1590\/S0074-02761945000600005","article-title":"Doen\u00e7a de Chagas","volume":"43","author":"Dias E.","year":"1945","journal-title":"Mem. Inst. Oswaldo Cruz","ISSN":"http:\/\/id.crossref.org\/issn\/0074-0276","issn-type":"print"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1161\/01.CIR.86.1.232","article-title":"Lumen diameter of normal human coronary arteries: Influence of age, sex, anatomic variation, and left ventricular hypertrophy or dilation","volume":"86","author":"Dodge J.T.","year":"1992","journal-title":"Circulation","ISSN":"http:\/\/id.crossref.org\/issn\/0009-7322","issn-type":"print"},{"key":"ref15","first-page":"337","article-title":"Gewichtsbestimmungen der reinen Muskelmasse beider Herzkammern bei normaler und pathologischer Herzbelastung","volume":"105","author":"Dull M.","year":"1941","journal-title":"Beitr. path. Anat."},{"key":"ref16","first-page":"81","article-title":"Coronariografia post-mortem na cardite chag\u00e1sica cr\u00f4nica: Correla\u00e7\u00e3o an\u00e1tomo-radiol\u00f3gica","volume":"34","author":"Ferreira C.S.","year":"1980","journal-title":"Arq. bras. Cardiol.","ISSN":"http:\/\/id.crossref.org\/issn\/0066-782X","issn-type":"print"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1136\/hrt.14.3.413","article-title":"Ventricular weight in cardiac hypertrophy","volume":"14","author":"Fulton R.M.","year":"1952","journal-title":"Brit. Heart J."},{"key":"ref18","first-page":"94","article-title":"Tripanosomiasis cruzi: anarquia angiotopografica por descapilarizaci\u00f3n mesenquimorreactiva, cofactor patog\u00e9nico de la miocardiopatia cr\u00f3nica","volume":"61","author":"J\u00f6rg M.E.","year":"1974","journal-title":"Pren. m\u00e9d. argent."},{"key":"ref19","first-page":"643","article-title":"Etiologia e patogenia do megaes\u00f4fago no Brasil","volume":"47","author":"K\u00f6berle F.","year":"1955","journal-title":"Rev. paul. Med.","ISSN":"http:\/\/id.crossref.org\/issn\/0035-0362","issn-type":"print"},{"key":"ref20","first-page":"9","article-title":"Cardiopatia chag\u00e1sica","volume":"53(3)","author":"K\u00f6berle F.","year":"1958","journal-title":"Hospital"},{"key":"ref21","first-page":"404","article-title":"Patologia y anatomia patologica de la enfermedad de Chagas","volume":"51","author":"K\u00f6berle F.","year":"1961","journal-title":"Bol. Ofic. sanit. Panamer.","ISSN":"http:\/\/id.crossref.org\/issn\/0030-0632","issn-type":"print"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0065-308X(08)60472-8","article-title":"Chagas' disease and Chagas' syndromes: the pathology of American trypanosomiasis","volume":"6","author":"K\u00f6berle F.","year":"1968","journal-title":"Advanc. Parasit.","ISSN":"http:\/\/id.crossref.org\/issn\/0065-308X","issn-type":"print"},{"key":"ref23","series-title":"Infektionskrankheiten: Band IV. Rickettsiosen und Protozoenkrankheiten","first-page":"290","volume-title":"Chagas-Krankheit und Chagas-Leiden","author":"K\u00f6berle F.","year":"1972"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1161\/01.CIR.14.6.1035","article-title":"Chagas' disease","volume":"14","author":"Laranja F.S.","year":"1956","journal-title":"Circulation","ISSN":"http:\/\/id.crossref.org\/issn\/0009-7322","issn-type":"print"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/0002-9149(60)90084-9","article-title":"Heart failure from the point of view of quantitative anatomy","volume":"5","author":"Linzbach A.J.","year":"1960","journal-title":"Amer. J. Cardiol."},{"key":"ref26","first-page":"597","article-title":"Arteriolosclerose das finas ramifica\u00e7\u00f5es arteriais do mioc\u00e1rdio (coronarite chag\u00e1sica) e miocit\u00f3lise focal do mioc\u00e1rdio na cardiopatia chag\u00e1sica cr\u00f4nica","volume":"54","author":"Magarinos-Torres C.","year":"1958","journal-title":"Hospital"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1590\/S0074-02761960000200004","article-title":"Miocit\u00f3lise e fibrose focal do mioc\u00e1rdio na doen\u00e7a de Chagas","volume":"58","author":"Magarinos-Torres C.","year":"1960","journal-title":"Mem. Inst. Oswaldo Cruz","ISSN":"http:\/\/id.crossref.org\/issn\/0074-0276","issn-type":"print"},{"key":"ref28","first-page":"826","article-title":"Studies of the coronary circulation in Chagas' heart disease","volume":"113","author":"Marin-Neto J.A.","year":"1995","journal-title":"Rev. paul. Med.","ISSN":"http:\/\/id.crossref.org\/issn\/0035-0362","issn-type":"print"},{"key":"ref29","series-title":"Contribui\u00e7\u00e3o ao estudo da patogenia do \"aneurisma\" da ponta na cardiopatia chag\u00e1sica","author":"Mello de Oliveira J.A."},{"key":"ref30","first-page":"1","article-title":"Observa\u00e7\u00f5es sobre a histoqu\u00edmica de algumas enzimas do mioc\u00e1rdio na fase cr\u00f4nica da infec\u00e7\u00e3o experimental pelo Trypanosoma cruzi, Chagas, 1909, em ratos Wistar","volume":"22","author":"Mello de Oliveira J.A.","year":"1976","journal-title":"Rev. goiana Med.","ISSN":"http:\/\/id.crossref.org\/issn\/0034-9585","issn-type":"print"},{"key":"ref31","series-title":"Recent advances in cellular and molecular biology: V.3. Neurobiochemical transmitter pathways, adrenoceptors and muscarinic receptors","first-page":"213","volume-title":"Adrenergic receptors: is Chagas' heart disease a model to their study in a human pathologic condition?","author":"Mello de Oliveira J.A.","year":"1992"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0167-5273(97)00129-0","article-title":"Myocardial ventricular mass related to coronary artery distribution in human hearts","volume":"62","author":"Mello de Oliveira J.A.","year":"1997","journal-title":"Int. J. Cardiol."},{"key":"ref33","first-page":"139","article-title":"Do valor do exame macrosc\u00f3pico no diagn\u00f3stico da cardiopatia chag\u00e1sica","volume":"68","author":"Menezes H.","year":"1965","journal-title":"Hospital"},{"key":"ref34","series-title":"Alguns aspectos da anatomia patol\u00f3gica da cardite chag\u00e1sica cr\u00f4nica","author":"Mignone C.","year":"1958"},{"key":"ref35","first-page":"119","article-title":"Forma cardiaca de la trypanosomiasis cruzi","volume":"2","author":"Montes Pereja J.","year":"1938","journal-title":"Arch. urug. Cardiol."},{"key":"ref36","first-page":"77","article-title":"Cardiopatia \"chag\u00e1sica\" experimental","volume":"15","author":"Oliveira J.S.M.","year":"1969","journal-title":"Rev. goiana Med.","ISSN":"http:\/\/id.crossref.org\/issn\/0034-9585","issn-type":"print"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1136\/hrt.46.4.432","article-title":"Apical aneurysm of Chagas' heart disease","volume":"46","author":"Oliveira J.S.; Mello de Oliveira J.A.","year":"1981","journal-title":"Brit. Heart J."},{"key":"ref38","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/0002-8703(85)90598-8","article-title":"Increased capacity of the coronary arteries in chronic Chagas' heart disease: further support for the neurogenic pathogenesis concept","volume":"109","author":"Oliveira J.S.M.","year":"1985","journal-title":"Amer. Heart J.","ISSN":"http:\/\/id.crossref.org\/issn\/0002-8703","issn-type":"print"},{"key":"ref39","series-title":"Contribui\u00e7\u00e3o ao estudo da les\u00e3o vorticilar (especialmente do vortex esquerdo) na cardite chag\u00e1sica cr\u00f4nica","author":"Raso P."},{"key":"ref40","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1159\/000398095","article-title":"Chagas' disease","volume":"3","author":"Ribeiro dos Santos R.","year":"1981","journal-title":"Antibiot. and Chemother."},{"key":"ref41","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0002-8703(90)90191-Y","article-title":"Microvascular changes as a cause of chronic cardiomyopathy in Chagas' disease","volume":"120","author":"Rossi M.A.","year":"1990","journal-title":"Amer. Heart J.","ISSN":"http:\/\/id.crossref.org\/issn\/0002-8703","issn-type":"print"},{"key":"ref42","first-page":"403","article-title":"Relation of the anatomic pattern to pathologic conditions of the coronary arteries","volume":"30","author":"Schlesinger M. J.","year":"1940","journal-title":"Arch. Path.","ISSN":"http:\/\/id.crossref.org\/issn\/0363-0153","issn-type":"print"},{"key":"ref43","series-title":"Nonparametric statistics for the behavioral sciences","first-page":"95","author":"Spiegel S.","year":"1956"},{"key":"ref44","first-page":"320","article-title":"Estudio anatomopatol\u00f3gico de 210 casos de miocardiopatias en Venezuela","volume":"15","author":"Suarez J.A.","year":"1968","journal-title":"Acta m\u00e9d. venez."},{"key":"ref45","first-page":"163","article-title":"The immunology of experimental Chagas' disease: IV. The production of lesions in rabbits similar of those of Chagas' disease in man","volume":"80","author":"Teixeira A.R.L.","year":"1975","journal-title":"Amer. J. Path.","ISSN":"http:\/\/id.crossref.org\/issn\/0002-9440","issn-type":"print"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/S0140-6736(61)91723-8","article-title":"Relative isch\u00e6mia in the hypertrophied heart","volume":"1","author":"Woods J.D.","year":"1961","journal-title":"Lancet","ISSN":"http:\/\/id.crossref.org\/issn\/0099-5355","issn-type":"print"}],"container-title":["Revista do Instituto de Medicina Tropical de S\u00e3o Paulo"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/rimtsp\/v40n5\/40n5a7.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,5,24]],"date-time":"2017-05-24T18:37:21Z","timestamp":1495651041000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0036-46651998000500007&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,9]]},"references-count":46,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1998,9]]}},"alternative-id":["S0036-46651998000500007"],"URL":"https:\/\/doi.org\/10.1590\/s0036-46651998000500007","relation":{},"ISSN":["0036-4665"],"issn-type":[{"value":"0036-4665","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,9]]}}}