{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T05:44:51Z","timestamp":1759815891857},"reference-count":26,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Inst. Med. trop. S. Paulo"],"published-print":{"date-parts":[[2002,7]]},"abstract":"<jats:p>The authors report a male patient, a seller with no detected immunosuppression, with an extensive ulcerated skin lesion localized on the left forearm, caused by Cryptococcus neoformans var. gattii serotype B. Oral treatment with fluconazole was successful. A review of the literature showed the rarity of this localization in HIV-negative patients. In contrast, skin lesions frequently occurs in HIV-positive patients, with Cryptococcus neoformans var. neoformans serotype A predominating as the etiological agent. In this paper, the pathogenicity of C. neoformans to skin lesions in patients immunocompromised or not, is discussed, showing the efficacy of fluconazole for the treatment of these processes.<\/jats:p>","DOI":"10.1590\/s0036-46652002000400008","type":"journal-article","created":{"date-parts":[[2005,4,27]],"date-time":"2005-04-27T13:30:17Z","timestamp":1114608617000},"page":"225-228","source":"Crossref","is-referenced-by-count":22,"title":["Primary cutaneous cryptococcosis due to Cryptococcus neoformans var. gattii serotype B, in an immunocompetent patient"],"prefix":"10.1590","volume":"44","author":[{"given":"Carlos da Silva","family":"LACAZ","sequence":"first","affiliation":[{"name":"Instituto de Medicina Tropical de S\u00e3o Paulo; Universidade de S\u00e3o Paulo, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth Maria","family":"HEINS-VACCARI","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Tropical de S\u00e3o Paulo; Universidade de S\u00e3o Paulo, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna L.","family":"HERN\u00c1NDEZ-ARRIAGADA","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Tropical de S\u00e3o Paulo; Universidade de S\u00e3o Paulo, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo Lacaz","family":"MARTINS","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina do ABC, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9lia A.L.","family":"PREARO","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina do ABC, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone Miwa","family":"CORIM","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Tropical de S\u00e3o Paulo; Universidade de S\u00e3o Paulo, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilena dos Anjos","family":"MARTINS","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Micologia M\u00e9dica do Instituto Adolfo Lutz, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","series-title":"Avalia\u00e7\u00e3o da virul\u00eancia de Cryptococcus neoformans (Vuillemin, 1901) variedade neoformans (Vuillemin, 1901) e var: gattii (Vanbreuseghem & Takashiro, 1970) em ratos imunossuprimidos","author":"ALMEIDA FILHO O.M. de","year":"2001"},{"key":"ref2","series-title":"Sorotipos, diversidade gen\u00e9tica, determina\u00e7\u00e3o de \"mating - types\" em amostras ambientais e cl\u00ednicas de Cryptococcus neoformans isoladas no Brasil","author":"BARRETO DE OLIVEIRA M.T.","year":"2001"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/j.1439-0507.1996.tb00097.x","article-title":"Primary cutaneous cryptococcosis following trauma of the right forearm","volume":"39","author":"BOHNE T.","year":"1996","journal-title":"Mycoses","ISSN":"http:\/\/id.crossref.org\/issn\/0933-7407","issn-type":"print"},{"key":"ref4","series-title":"Criptococose sist\u00eamica end\u00eamica pela variedade gattii no meio Norte do Brasil","author":"CAVALCANTI M. dos A.S.","year":"1997"},{"key":"ref5","series-title":"Neurocriptococose pedi\u00e1trica no Estado do Par\u00e1: espectro de achados tomogr\u00e1ficos na infec\u00e7\u00e3o por Cryptococcus neoformans var. gattii","author":"CORR\u00caA M. do P.S.C.","year":"2001"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0723-2020(00)80028-4","article-title":"Molecular sequence analysis of the intergenic spacer (IGS) associated with rDNA of the two varieties of the pathogenic yeast C","volume":"23","author":"DIAZ M.R.","year":"2000","journal-title":"neoformans. 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