{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T08:41:06Z","timestamp":1775551266432,"version":"3.50.1"},"reference-count":29,"publisher":"FapUNIFESP (SciELO)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Inst. Med. trop. S. Paulo"],"published-print":{"date-parts":[[2003,4]]},"abstract":"<jats:p>Patients with megaesophagus (ME) have increased prevalence of cancer of the esophagus. In contrast, a higher incidence of colorectal cancer is not observed in patients with megacolon (MC). MC is very common in some regions of Brazil, where it is mainly associated with Chagas disease. We reviewed the pathology records of surgical specimens of all patients submitted for surgical resection of MC in the Hospital das Cl\u00ednicas of the Faculty of Medicine of Ribeir\u00e3o Preto (HC-FMRP), from the University of S\u00e3o Paulo. We found that 894 patients were operated from 1952 until 2001 for MC resection. Mucosal ulcers, hyperplasia and chronic inflammation were frequently found, while polyps were uncommon. No patients with MC presented any type of colonic neoplasm. This observation reinforces the hypothesis that MC has a negative association with cancer of the colon. This seems to contradict the traditional concept of carcinogenesis in the colon, since patients with MC presents important chronic constipation that is thought to cause an increase in risk for colon cancer. MC is also associated with other risk factors for cancer of colon, such as hyperplasia, mucosal ulcers and chronic inflammation. In ME these factors lead to a remarkable increase in cancer risk. The study of mucosal cell proliferation in MC may provide new insights and useful information about the role of constipation in colonic carcinogenesis.<\/jats:p>","DOI":"10.1590\/s0036-46652003000200007","type":"journal-article","created":{"date-parts":[[2005,4,27]],"date-time":"2005-04-27T13:31:23Z","timestamp":1114608683000},"page":"91-93","source":"Crossref","is-referenced-by-count":47,"title":["A retrospective study of histopathological findings in 894 cases of megacolon: what is the relationship between megacolon and colonic cancer?"],"prefix":"10.1590","volume":"45","author":[{"given":"S\u00e9rgio Britto","family":"Garcia","sequence":"first","affiliation":[{"name":"USP,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre Luis","family":"Aranha","sequence":"additional","affiliation":[{"name":"USP,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio Rog\u00e9rio Brosci","family":"Garcia","sequence":"additional","affiliation":[{"name":"USP,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filipe Volpe","family":"Basile","sequence":"additional","affiliation":[{"name":"USP,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9 P\u00e9ra Marques","family":"Pinto","sequence":"additional","affiliation":[{"name":"USP,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enio Chaves de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Universidade Federal de Goias,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9rgio","family":"Zucoloto","sequence":"additional","affiliation":[{"name":"USP,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"879","DOI":"10.4269\/ajtmh.1999.60.879","article-title":"Leiomyosarcoma of the esophagus in a patient with chagasic megaesophagus: case report and literature review","volume":"60","author":"Adad S.J.","year":"1999","journal-title":"Amer. 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