{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T03:34:30Z","timestamp":1784691270550,"version":"3.55.0"},"reference-count":31,"publisher":"FapUNIFESP (SciELO)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Inst. Med. trop. S. Paulo"],"published-print":{"date-parts":[[2003,12]]},"abstract":"<jats:p>Cytomegalovirus (CMV) disease in acquired immunodeficiency syndrome (AIDS) patients most commonly presents as chorioretinitis and gastro-intestinal infection. Neurological involvement due to CMV may cause several clinical presentations: polyradiculitis, myelitis, encephalitis, ventriculo-encephalitis, and mononeuritis multiplex. Rarely, cerebral mass lesion is described. We report a 39 year-old woman with AIDS and previous cerebral toxoplasmosis. She presented with fever, seizures, and vulval ulcers. Her chest X-ray showed multiple lung nodules, and a large frontal lobe lesion was seen in a brain computed tomography scan. She underwent a brain biopsy through a frontal craniotomy, but her condition deteriorated and she died in the first postoperative day. Histopathological studies and immunohistochemistry disclosed CMV disease, and there was no evidence of cerebral toxoplasmosis, bacterial, mycobacterial or fungal infection. CMV disease should be considered in the differential diagnosis of cerebral mass lesion in AIDS patients. High suspicion index, timely diagnostic procedures (surgical or minimally invasive), and proper utilization of prophylactic and therapeutic medication could improve outcome of these patients.<\/jats:p>","DOI":"10.1590\/s0036-46652003000600007","type":"journal-article","created":{"date-parts":[[2005,4,27]],"date-time":"2005-04-27T13:32:09Z","timestamp":1114608729000},"page":"333-337","source":"Crossref","is-referenced-by-count":8,"title":["Cerebral mass lesion due to cytomegalovirus in a patient with AIDS: case report and literature review"],"prefix":"10.1590","volume":"45","author":[{"given":"Jos\u00e9 E.","family":"Vidal","sequence":"first","affiliation":[{"name":"Instituto de Infectologia Em\u00edlio Ribas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafi F.","family":"Dauar","sequence":"additional","affiliation":[{"name":"Instituto de Infectologia Em\u00edlio Ribas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augusto C.","family":"Penalva de Oliveira","sequence":"additional","affiliation":[{"name":"Instituto de Infectologia Em\u00edlio Ribas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o F.G.S.","family":"Coelho","sequence":"additional","affiliation":[{"name":"Instituto de Infectologia Em\u00edlio Ribas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diogo L.M.","family":"Lins","sequence":"additional","affiliation":[{"name":"Instituto de Infectologia Em\u00edlio Ribas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1212\/WNL.55.8.1194","article-title":"AIDS-related focal brain lesions in the era of highly active antiretroviral therapy","volume":"55","author":"AMMASSARI A.","year":"2000","journal-title":"Neurology","ISSN":"https:\/\/id.crossref.org\/issn\/0028-3878","issn-type":"print"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1212\/WNL.50.1.21","article-title":"Evaluation and management of intracranial mass lesion in AIDS: Report of the Quality Standars Subcommittee of the American Academy of Neurology","volume":"50","year":"1998","journal-title":"Neurology","ISSN":"https:\/\/id.crossref.org\/issn\/0028-3878","issn-type":"print"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1097\/00002030-200003310-00007","article-title":"Induction and maintenance therapy of cytomegalovirus central nervous system infection in HIV-infected patients","volume":"14","author":"ANDUZE-FARIS B.M.","year":"2000","journal-title":"AIDS","ISSN":"https:\/\/id.crossref.org\/issn\/0269-9370","issn-type":"print"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"577","DOI":"10.7326\/0003-4819-125-7-199610010-00008","article-title":"Cytomegalovirus encephalitis","volume":"125","author":"ARRIBAS J.R.","year":"1996","journal-title":"Ann. intern. 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