{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T09:08:46Z","timestamp":1724749726326},"reference-count":20,"publisher":"FapUNIFESP (SciELO)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Inst. Med. trop. S. Paulo"],"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:p>Human astroviruses have been increasingly identified as important agents of diarrheal disease in children. However, the disease burden of astrovirus infection is still incompletely assessed. This paper reports results on the epidemiological and clinical characteristics of astrovirus-associated diarrhea, as well as the impact of astrovirus infection on the ambulatory setting at a Public Hospital in C\u00f3rdoba city, Argentina. From February 2001 through January 2002, 97 randomly selected outpatient visits for diarrhea among children &lt; 36 months old were enrolled. A single specimen of stool from each child was collected and tested for astrovirus antigen by enzyme immunoassay. Astroviruses were detected in 12.37% of the diarrheal episodes. All the positive cases occurred in children 4 to 18 months, but the highest rate was in children aged 4 to 6 months (23.80%). The clinical symptoms of astrovirus associated-diarrhea were fever 41.66%, vomiting 25.00% and dehydration 8.33%; overall 16.66% required hospitalization. Astrovirus was identified through the year and no seasonally pattern was detected (cool semester 15.21% versus warm semester 9.80% p &gt; 0.05). According to our estimation about one out of seventy-four children in this cohort would be assisted annually for an astroviral-diarrheal episode in the Public Hospital and one out of eight diarrheal cases could be attributed to astrovirus infection. Astrovirus is a common symptomatic infection in pediatric outpatient visits in the public hospital in the study area, contributing 12.37% of the overall morbidity from diarrhea.<\/jats:p>","DOI":"10.1590\/s0036-46652004000200007","type":"journal-article","created":{"date-parts":[[2005,4,27]],"date-time":"2005-04-27T13:33:00Z","timestamp":1114608780000},"page":"93-96","source":"Crossref","is-referenced-by-count":17,"title":["Childhood astrovirus-associated diarrhea in the ambulatory setting in a Public Hospital in Cordoba city, Argentina"],"prefix":"10.1590","volume":"46","author":[{"given":"Miguel O.","family":"Giordano","sequence":"first","affiliation":[{"name":"Universidad Nacional de C\u00f3rdoba, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura C.","family":"Martinez","sequence":"additional","affiliation":[{"name":"Universidad Nacional de C\u00f3rdoba, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda B.","family":"Isa","sequence":"additional","affiliation":[{"name":"Universidad Nacional de C\u00f3rdoba, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirtha","family":"Paez Rearte","sequence":"additional","affiliation":[{"name":"Ministerio de Salud P\u00fablica de la Provincia de C\u00f3rdoba, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia V.","family":"Nates","sequence":"additional","affiliation":[{"name":"Universidad Nacional de C\u00f3rdoba, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/S0140-6736(75)92581-7","article-title":"Viruses and gastroenteritis in infants","volume":"1","author":"APPLETON H.","year":"1975","journal-title":"Lancet","ISSN":"http:\/\/id.crossref.org\/issn\/0099-5355","issn-type":"print"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"3055","DOI":"10.1128\/JCM.37.9.3055-3058.1999","article-title":"Prevalence of group A rotavirus, human calicivirus, astrovirus and adenovirus type 40 and 41 infections among children with acute gastroenteritis in Dijon, France","volume":"37","author":"BON F.","year":"1999","journal-title":"J. clin. 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Virol."},{"key":"ref7","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1097\/00006454-199808000-00012","article-title":"A prospective study of astrovirus diarrhea of infancy in Mexico City","volume":"17","author":"GUERRERO M.L.","year":"1998","journal-title":"Pediat. infect. Dis. J."},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1056\/NEJM199106203242501","article-title":"Astroviruses as a cause of gastroenteritis in children","volume":"324","author":"HERRMANN J.E.","year":"1991","journal-title":"New Engl. J. Med.","ISSN":"http:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1128\/CDLI.5.1.33-37.1998","article-title":"Age-stratified seroprevalence of neutralizing antibodies to astrovirus types 1 to 7 in humans in The Netherlands","volume":"5","author":"KOOPMANS M.P.","year":"1998","journal-title":"Clin. diagn. Lab. 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