{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T10:17:13Z","timestamp":1762251433208},"reference-count":20,"publisher":"FapUNIFESP (SciELO)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Inst. Med. trop. S. Paulo"],"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:p>This work analyzed the histopathology and epidermal Langerhans cells (LC) of Montenegro skin test (MST) in patients with American tegumentary leishmaniasis (ATL) in order to in situ characterize and compare the immunological reaction of the two major clinical forms of ATL, localized cutaneous leishmaniasis (LCL) and mucocutaneous leishmaniasis (MCL). MST histopathology of both LCL and MCL showed superficial and deep perivascular inflammatory infiltrate composed mainly of lymphocytes and histiocytes. Epidermal LC population was higher in MST biopsies taken from LCL patients when compared to MCL group, at 48 and 72 hours after antigen inoculation. Increased number of epidermal LC displayed in MST biopsies of LCL patients represents specific cellular immunity against parasites. The decrease of LC in MST biopsies of MCL patients does not necessarily indicate a worse specific cellular immunity in this clinical form of leishmaniasis.<\/jats:p>","DOI":"10.1590\/s0036-46652008000500007","type":"journal-article","created":{"date-parts":[[2008,10,22]],"date-time":"2008-10-22T15:11:04Z","timestamp":1224688264000},"page":"283-286","source":"Crossref","is-referenced-by-count":5,"title":["American tegumentary leishmaniasis: langerhans cells in montenegro skin test"],"prefix":"10.1590","volume":"50","author":[{"given":"Marcia Ferraz","family":"Nogueira","sequence":"first","affiliation":[{"name":"Universidade de Santo Amaro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00edrian N.","family":"Sotto","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz Carlos","family":"Cuc\u00e9","sequence":"additional","affiliation":[{"name":"Universidade de Santo Amaro, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1093\/infdis\/167.2.418","article-title":"Parasitism of epidermal Langerhans cells in experimental cutaneous leishmaniasis with Leishmania major","volume":"167","author":"BLANK C.","year":"1993","journal-title":"J. infect. 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Histopath."},{"key":"ref9","first-page":"293","article-title":"Intradermorrea\u00e7\u00e3o de Montenegro: aspectos histopatol\u00f3gicos e imunol\u00f3gicos","volume":"XIX","author":"FESTA NETO C.","year":"1991","journal-title":"Med. cut. ibero lat.-amer."},{"key":"ref10","series-title":"Contribui\u00e7\u00e3o ao estudo da rea\u00e7\u00e3o de Montenegro","author":"GUEDES A.C.M.","year":"1980"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1084\/jem.165.3.763","article-title":"Distribution and turnover of Langerhans cells during delayed immune responses in human skin","volume":"165","author":"KAPLAN G.","year":"1987","journal-title":"J. exp. 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Paulo"},{"key":"ref15","first-page":"5","article-title":"An\u00e1tomo-pathologia da leishmaniose cut\u00e2nea (\u00falcera de Bauru)","volume":"15","author":"MONTENEGRO J.","year":"1924","journal-title":"An. paul. Med. Cirurg."},{"key":"ref16","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0001-706X(89)90006-5","article-title":"Cutaneous leishmaniasis of the New World: diagnostic immunopathology and antigen pathways in skin and mucosa","volume":"46","author":"SOTTO M.N.","year":"1989","journal-title":"Acta trop."},{"key":"ref17","first-page":"499","article-title":"Epidermal Langerhans cells in infectious diseases","volume":"4","author":"TAPIA F.J.","year":"1989","journal-title":"Histol. Histopath."},{"key":"ref18","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1600-0625.1994.tb00261.x","article-title":"Adhesion molecule in lesions of American cutaneous leishmaniasis","volume":"3","author":"TAPIA F.J.","year":"1994","journal-title":"Exp. 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