{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:00:39Z","timestamp":1791234039684,"version":"4.1.0"},"reference-count":51,"publisher":"FapUNIFESP (SciELO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Inst. Med. trop. S. Paulo"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:p>The effects of both garlic (Allium sativum) and onion (Allium cepa) on some biochemical parameters in Schistosoma mansoni infected mice individually and mixed either with or without the currently used drug, praziquantel (PZQ) were investigated. These involved some immunological parameters, namely IgM, IgG, interleukins 2 and 6 (IL-2 and 6) and tumor necrosis factor (TNF-\u03b1), some antioxidant enzymes [catalase, superoxide dismutase (SOD) and glutathione peroxidase (GPX)]. In addition, parasitological and histopathological investigations were performed. No changes were observed in the normal control mice treated with dry extract of onion or garlic, individually or mixed, with or without PZQ, compared to the normal healthy control group. Infection with S. mansoni showed an increase in IgG, IgM, IL-2, IL-6, TNF-\u03b1 and catalase enzyme, accompanied with a decrease in GPX and SOD antioxidant enzyme activities. Remarkable amelioration was noticed in the levels of all the measured parameters in S. mansoni infected mice after administration of the studied extracts. Moreover a significant reduction in worm burden, hepatic and intestinal eggs and oogram count was noticed which was reflected in normalization of liver architecture.<\/jats:p>","DOI":"10.1590\/s0036-46652011000300007","type":"journal-article","created":{"date-parts":[[2011,7,7]],"date-time":"2011-07-07T18:04:53Z","timestamp":1310061893000},"page":"155-163","source":"Crossref","is-referenced-by-count":45,"title":["Therapeutic Effects of Allium sativum and Allium cepa in Schistosoma mansoni experimental infection"],"prefix":"10.1590","volume":"53","author":[{"given":"Mona Mohamed","family":"Mantawy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanan Farouk","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maha 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experimentally infected rats","volume":"35","author":"Abu-El-Ezz NM.","year":"2005","journal-title":"J Egypt Soc Parasitol."},{"key":"ref5","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3923\/tmr.2007.37.43","article-title":"Evaluation of antioxidants effect of Citrus reticulate in Schistosoma mansoni infected mice","volume":"2","author":"Ali HF.","year":"2007","journal-title":"Trends Med Res."},{"key":"ref6","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.molbiopara.2008.08.004","article-title":"Microarray based analysis of temperature and oxidative stress induced messenger RNA in Schistosoma mansoni","volume":"162","author":"Aragon AD","year":"2008","journal-title":"Mol Biochem Parasitol","ISSN":"https:\/\/id.crossref.org\/issn\/0166-6851","issn-type":"print"},{"key":"ref7","first-page":"27","article-title":"Immunoglobulin profile in mice harbouring Schistosoma mansoni isolates showing different susceptibility to the praziquantel over different life cycle passages (snail-mouse)","volume":"28","author":"Botros SS","year":"2006","journal-title":"Egypt J Schistosomiasis Infect Dis."},{"key":"ref8","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/S0169-4758(98)01317-9","article-title":"Cytokine interaction and immune responses during Schistosoma mansoni infection","volume":"14","author":"Brunet LR","year":"1998","journal-title":"Parasitol Today."},{"key":"ref9","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0165-2427(96)05775-3","article-title":"Cytokine profile induced by a primary infection with Ostertagia ostertagi in cattle","volume":"58","author":"Canals A","year":"1997","journal-title":"Vet Immunol Immunopathol","ISSN":"https:\/\/id.crossref.org\/issn\/0165-2427","issn-type":"print"},{"key":"ref10","series-title":"Progress in immunology","first-page":"2","volume-title":"Effector mechanisms against schistosom","author":"Capron A","year":"1983"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"62","DOI":"10.4269\/ajtmh.1971.20.62","article-title":"Rate of destruction of Schistosoma mansoni eggs in tissues of mice","volume":"20","author":"Cheever AW","year":"1971","journal-title":"Am J Trop Med Hyg."},{"key":"ref12","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1590\/S0036-46652008000100007","article-title":"The effect of antioxidant properties of aqueous garlic extract and Nigella sativa as antischistosomiasis agents in mice","volume":"50","author":"El-Shenawy NS","year":"2008","journal-title":"Rev Inst Med Trop Sao Paulo","ISSN":"https:\/\/id.crossref.org\/issn\/0036-4665","issn-type":"print"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/S0168-8278(99)80189-5","article-title":"Development of eosinophil peroxidase activity and concomitant alteration of antioxidant defenses in the liver of mice infected with Schistosoma mansoni","volume":"30","author":"Gharib B","year":"1999","journal-title":"J Hepatol","ISSN":"https:\/\/id.crossref.org\/issn\/0168-8278","issn-type":"print"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1046\/j.1365-3083.2000.00803.x","article-title":"Garlic induces a shift in cytokine pattern in Leishmania major-infected Balb\/c mice","volume":"52","author":"Ghazanfari T","year":"2000","journal-title":"Scand J Immunol."},{"key":"ref15","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.jep.2005.08.026","article-title":"Enhancement of peritoneal macrophages phagocytic activity against Leshmania major by garlic (Allium sativum) treatment","volume":"103","author":"Ghazanfari T","year":"2006","journal-title":"J Ethnopharmacol","ISSN":"https:\/\/id.crossref.org\/issn\/0378-8741","issn-type":"print"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.vetpar.2006.04.021","article-title":"Use of plants in novel approach for control of gastrointestinal helminthes in livestock with emphasis on small ruminants","volume":"139","author":"Githiori JB","year":"2006","journal-title":"Vet Parasitol","ISSN":"https:\/\/id.crossref.org\/issn\/0304-4017","issn-type":"print"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2730","DOI":"10.4049\/jimmunol.129.6.2739","article-title":"In vitro and in vivo effector function of rat IgG2a monoclonal anti S. mansoni antibodies","volume":"129","author":"Grzych JM","year":"1982","journal-title":"J Immunol","ISSN":"https:\/\/id.crossref.org\/issn\/0022-1767","issn-type":"print"},{"key":"ref18","first-page":"539","article-title":"The role of food additives in the control of some parasites contaminating vegetables","volume":"13","author":"Hamdy EL","year":"1983","journal-title":"Egypt J Parasitol"},{"key":"ref19","first-page":"554","article-title":"Excretory-secretory product of Fasciola hepatica worm protects against Schistosoma mansoni infection in mice","volume":"44","author":"Hamed MA.","year":"2006","journal-title":"Indian J Exp Biol."},{"key":"ref20","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1023\/A:1007065917665","article-title":"Differential effect of schisandrin B and dimethyl diphenyl bicarboxylate (DDB) on hepatic mitochondrial glutathione redox status in carbon tetrachloride intoxicated mice","volume":"205","author":"Ip SP","year":"2000","journal-title":"Mol Cell Biochem."},{"key":"ref21","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.foodchem.2008.11.043","article-title":"Evaluation of in vivo antioxidant activities of Ganoderma lucidum polysaccharides in STZ-diabetic rats","volume":"115","author":"Jia J","year":"2009","journal-title":"Food Chem."},{"key":"ref22","doi-asserted-by":"crossref","first-page":"e206","DOI":"10.1371\/journal.pmed.0040206","article-title":"Thioredoxin glutathione reductase from Schistosoma mansoni, an essential parasite enzymes and a key drug target","volume":"4","author":"Kuntz AN","year":"2007","journal-title":"PLOS Med."},{"issue":"3s","key":"ref23","doi-asserted-by":"crossref","first-page":"1075S","DOI":"10.1093\/jn\/131.3.1075S","article-title":"Immunomodulatory effects of aged garlic extract","volume":"131","author":"Kyo E","year":"2001","journal-title":"J Nutr."},{"key":"ref24","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/S0169-4758(98)01261-7","article-title":"Do antioxidants play a role in schistosome host-parasite interactions?","volume":"14","author":"Loverde PT.","year":"1998","journal-title":"Parasitol Today."},{"key":"ref25","doi-asserted-by":"crossref","first-page":"724","DOI":"10.3923\/jms.2007.724.731","article-title":"In vivo, the immunological effects of Fasciola gigantica worms homogenate mixed with saponin on mice infected with Schistosoma mansoni","volume":"7","author":"Maghraby SA","year":"2007","journal-title":"J Med Sci."},{"key":"ref26","first-page":"169","article-title":"Cellular constituent and intercellular adhesion in Schistosoma mansoni granuloma: an ultrastructural study","volume":"28","author":"Mansy SS.","year":"1998","journal-title":"J Egypt Soc Parasitol","ISSN":"https:\/\/id.crossref.org\/issn\/0253-5890","issn-type":"print"},{"key":"ref27","first-page":"271","article-title":"Effect of Allium cepa and Allium sativum feeding on glucose, glycogen, and protein bands profile and phenol oxidase activity in Biomphalaria alexandrina","volume":"32","author":"Mantawy MM","year":"2002","journal-title":"J Egypt Soc Parasitol","ISSN":"https:\/\/id.crossref.org\/issn\/0253-5890","issn-type":"print"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"319","DOI":"10.21608\/ejhm.2006.17943","article-title":"Potency of Allium sativum and Allium cepa oils against Schistosoma mansoni infection in mice","volume":"23","author":"Metwally NS.","year":"2006","journal-title":"Egypt J Hosp Med."},{"key":"ref29","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0022-1759(96)00244-X","article-title":"A highly sensitive fluorescent microassay of H2O2 release from activated human leukocytes using a dihydroxyphenoxazine derivative","volume":"202","author":"Mohanty JG","year":"1997","journal-title":"J Immunol Methods","ISSN":"https:\/\/id.crossref.org\/issn\/0022-1759","issn-type":"print"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1086\/317919","article-title":"Altered levels of hypothalamic-pituitary-adrenocortical axis hormones in baboons and mice during the course of infection with Schistosoma mansoni","volume":"183","author":"Morales-Montor J","year":"2001","journal-title":"J Infect Dis","ISSN":"https:\/\/id.crossref.org\/issn\/0022-1899","issn-type":"print"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"19","DOI":"10.2307\/3274166","article-title":"An efficient method for the exposure of mice to cercariae of Schistosoma mansoni","volume":"39","author":"Oliver L","year":"1952","journal-title":"J Parasitol","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3395","issn-type":"print"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1258\/0004563053492838","article-title":"Malondialdehyde , glutathione, glutathione peroxidase and homocysteine levels in type 2 diabetic patients with and without microalbuminuria","volume":"42","author":"Ozdemir G","year":"2005","journal-title":"Ann Clin Biochem","ISSN":"https:\/\/id.crossref.org\/issn\/0004-5632","issn-type":"print"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/S0035-9203(00)90443-7","article-title":"Hyaluronate levels and markers of oxidative stress in the serum Sudanese subjects at risk of infection with Schistosoma mansoni","volume":"94","author":"Pascal M","year":"2000","journal-title":"Trans R Soc Med Hyg."},{"key":"ref34","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1023\/A:1011050619406","article-title":"Post-transcriptional control of catalase expression in garlic-treated rats","volume":"216","author":"Pedraza-Chaverri J","year":"2001","journal-title":"Molec Cell Biochem"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"201","DOI":"10.4269\/ajtmh.1962.11.201","article-title":"New approach to the screening of drugs in experimental Schistosomiasis mansoni in mice","volume":"11","author":"Pellegrino J","year":"1962","journal-title":"Am J Trop Med Hyg."},{"key":"ref36","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.exppara.2008.03.012","article-title":"Schistosoma mansoni: lack of correlation between praziquantel-induced intra-worm calcium influx and parasite death","volume":"119","author":"Pica-Mattoccia L","year":"2008","journal-title":"Exp Parasitol."},{"key":"ref37","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/j.1365-3024.1990.tb00975.x","article-title":"Schistosoma mansoni: Histological analysis of the synergetic interaction between vaccine immunity and praziquantel therapy in the lungs of mice","volume":"12","author":"Piper KP","year":"1990","journal-title":"Parasite Immunol","ISSN":"https:\/\/id.crossref.org\/issn\/0141-9838","issn-type":"print"},{"key":"ref38","first-page":"949","article-title":"The effect of garlic on some parasitological parameters and on hepatic tissues reaction in experimental schistosomiasis mansoni","volume":"3","author":"Riad NH","year":"2007","journal-title":"J Appl Sci Res"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"951S","DOI":"10.1093\/jn\/131.3.951S","article-title":"Historical perspective on the use of garlic","volume":"131","author":"Rivlin RS.","year":"2001","journal-title":"J Nutr."},{"key":"ref40","first-page":"319","article-title":"Measurement of urea cycle enzyme activities in mice livers under the influence of different stages of Schistosoma mansoni infection and Curcuma longa extract","volume":"32","author":"Rizk M","year":"2000","journal-title":"J Egypt Ger Soc Zool."},{"key":"ref41","doi-asserted-by":"crossref","first-page":"e127","DOI":"10.1371\/journal.pntd.0000127","article-title":"Quantitative high-throughout screen identifies inhibitors of the Schistosoma mansoni redox cascade","volume":"2","author":"Simeonov A","year":"2008","journal-title":"PLOS Negl Trop Dis."},{"key":"ref42","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1017\/S0031182000086248","article-title":"The infection of laboratory hosts with cercariae of Schistosoma mansoni and the recovery of worms","volume":"55","author":"Smithers SR","year":"1965","journal-title":"Parasitology","ISSN":"https:\/\/id.crossref.org\/issn\/0031-1820","issn-type":"print"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1016\/S0278-6915(03)00146-7","article-title":"Modulation of lipopolysaccharide-induced proinflammatory cytokine production in vitro and in vivo by the herbal constituents apigenin (chamomile), ginsenoside Rb1 and parthenolide (feverfew)","volume":"41","author":"Smolinski AT","year":"2003","journal-title":"Food Chem Toxicol."},{"key":"ref44","first-page":"455","article-title":"Effect of carnosine administration on certain metabolic parameters in bilharzial infected hamsters","volume":"30","author":"Soliman KM","year":"2000","journal-title":"J Egypt Soc Parasitol."},{"key":"ref45","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1271\/bbb.70472","article-title":"Antioxidative and hypolipidemic effects of diosgenin, a steroidal saponin of yam (Dioscorea spp.), on high-cholesterol fed rats","volume":"71","author":"Son IS","year":"2007","journal-title":"Biosci Biotechnol Biochem","ISSN":"https:\/\/id.crossref.org\/issn\/0916-8451","issn-type":"print"},{"key":"ref46","first-page":"33","article-title":"Testing CK group preparations in hymenolepiasis in white mice","volume":"4","author":"Streliaeva AV","year":"2000","journal-title":"Med Parazitol (Mosk.)"},{"key":"ref47","first-page":"66","article-title":"Efficacy of garlic as an anthelmintic in donkeys","volume":"54","author":"Sutton GA","year":"1999","journal-title":"Isr J Vet Med."},{"key":"ref48","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0020-7519(86)90113-X","article-title":"Schistosoma mansoni vaccination with adult worm antigens","volume":"16","author":"Tendler M","year":"1986","journal-title":"Int J Parasitol."},{"key":"ref49","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3136\/nskkk.49.25","article-title":"Application of novel assay methods for superoxide anion-scavenging activity to food samples","volume":"49","author":"Ukeda H","year":"2002","journal-title":"Nippon Shokuhin Kagaku Kogaku Kaishi"},{"key":"ref50","first-page":"735","article-title":"Granuloma formation around schistosome eggs as manifestation of delayed hypersensitivity","volume":"51","author":"Warren KS","year":"1967","journal-title":"Am J Pathol."},{"key":"ref51","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/273609a0","article-title":"The pathology, pathobiology and pathogensis","volume":"273","author":"Warren KS.","year":"1978","journal-title":"Nature","ISSN":"https:\/\/id.crossref.org\/issn\/0028-0836","issn-type":"print"}],"container-title":["Revista do Instituto de Medicina Tropical de S\u00e3o 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