{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T00:21:50Z","timestamp":1648599710482},"reference-count":17,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Inst. Med. trop. S. Paulo"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:p>Surfacen\u00ae is an exogenous natural lung surfactant, composed by phospholipids and hydrophobic proteins, which is applied successfully in Newborn Respiratory Distress Syndrome. In this paper, in vitro activity of Surfacen\u00ae against Leishmania amazonensis is described. The product showed activity against the amastigote form found in peritoneal macrophages from BALB\/c mice, with an IC50 value of 17.9 \u00b1 3.0 \u00b5g\/mL; while no toxic effect on host cell was observed up to 200 \u00b5g\/mL. 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