{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:48:01Z","timestamp":1759942081760},"reference-count":8,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Inst. Med. trop. S. Paulo"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p>Brain tuberculomas account for 10-20% of space occupying brain lesions in developing countries. Most lesions are observed at time of tuberculosis diagnosis or soon after starting treatment. We herein describe a 32 year-old patient with a 14-month history of headache and progressive visual loss. Her past medical history revealed pulmonary tuberculosis treated eight years before. A brain MRI showed a T1- and T2-weighted isointense contrast-enhancing lesion in the optic chiasm. A presumptive diagnosis of optochiasmatic tuberculoma was made and isoniazid, rifampin, pyrazinamide, and ethambutol were started. Despite treatment, the patient evolved to blindness. The prompt recognition of this condition is extremely important since the presence of optochiasmal enhancement is associated with blindness in patients with tuberculosis.<\/jats:p>","DOI":"10.1590\/s0036-46652012000400008","type":"journal-article","created":{"date-parts":[[2012,7,29]],"date-time":"2012-07-29T04:29:02Z","timestamp":1343536142000},"page":"229-230","source":"Crossref","is-referenced-by-count":3,"title":["Optochiasmatic tuberculoma as the sole manifestation of late recurrent tuberculosis"],"prefix":"10.1590","volume":"54","author":[{"given":"Marco A.","family":"Lima","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Aversa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pericles","family":"Maranh\u00e3o-Filho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela A.","family":"Lima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andre","family":"Curi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina A.","family":"Schmaltz","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavia M.","family":"Santanna","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","first-page":"137","article-title":"Tuberculome optochiasmatique: complication d'une m\u00e9ningite tuberculeuse","volume":"28","author":"Akhaddar A","year":"2001","journal-title":"J Neuroradiol","ISSN":"http:\/\/id.crossref.org\/issn\/0150-9861","issn-type":"print"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1586\/eri.11.93","article-title":"Tuberculous optochiasmatic arachnoiditis: a devastating form of tuberculous meningitis","volume":"9","author":"Garg RK","year":"2011","journal-title":"Expert Rev Anti Infect Ther"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/S0090-3019(99)00089-0","article-title":"Diagnostic efficacy of stereotactic biopsies in intracranial tuberculomas","volume":"52","author":"Mohanty A","year":"1999","journal-title":"Surg Neurol","ISSN":"http:\/\/id.crossref.org\/issn\/0090-3019","issn-type":"print"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S1473-3099(05)70299-1","article-title":"Intracranial tuberculomas developing while on therapy for pulmonary tuberculosis","volume":"5","author":"Nicolls DJ","year":"2005","journal-title":"Lancet Infect Dis"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1177\/0883073809350507","article-title":"Tuberculous meningitis-related optic neuritis: recovery of vision with thalidomide in 4 consecutive cases","volume":"25","author":"Schoeman JF","year":"2010","journal-title":"J Child Neurol","ISSN":"http:\/\/id.crossref.org\/issn\/0883-0738","issn-type":"print"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S0303-8467(00)00063-9","article-title":"Intrasellar tuberculoma - 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