{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T01:35:06Z","timestamp":1793064906158,"version":"4.5.0"},"reference-count":37,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Inst. Med. trop. S. Paulo"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:p>This study aimed to estimate the prevalence of paracoccidioidal infection by intradermal reaction (Delayed-Type Hypersensitivity, DTH) to Paracoccidioides brasiliensis in rural areas in Alfenas, Southern Minas Gerais (MG) State, Brazil, and to assess risk factors (gender, occupation, age, alcohol intake and smoking) associated with infection. We conducted a population-based cross-sectional study using intradermal tests with gp 43 paracoccidioidin in 542 participants, who were previously contacted by local health agents and so spontaneously attended the test. Participants underwent an interview by filling out a registration form with epidemiological data and were tested with an intradermal administration of 0.1 mL of paracoccidioidin in the left forearm. The test was read 48 hours after injection and was considered positive if induration was greater than or equal to 5 mm. Out of 542 participants, 46.67% were positive to the skin test. Prevalence increased in accordance with an increase of age. There was statistical significance only for males. Occupation, alcohol intake and smoking habits were not significantly associated with the risk of paracoccidioidomycosis infection. There is relevance of paracoccidioidomycosis infection in such rural areas, which suggests that further epidemiological and clinical studies on this mycosis should be done in the southern part of Minas Gerais State.<\/jats:p>","DOI":"10.1590\/s0036-46652014000400002","type":"journal-article","created":{"date-parts":[[2014,7,28]],"date-time":"2014-07-28T13:22:28Z","timestamp":1406553748000},"page":"281-285","source":"Crossref","is-referenced-by-count":15,"title":["PREVALENCE OF PARACOCCIDIOIDOMYCOSIS INFECTION BY INTRADERMAL REACTION IN RURAL AREAS IN ALFENAS, MINAS GERAIS, BRAZIL"],"prefix":"10.1590","volume":"56","author":[{"given":"Evandro Monteiro de S\u00e1","family":"Magalh\u00e3es","sequence":"first","affiliation":[{"name":"Universidade Federal de Alfenas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla de F\u00e1tima","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Universidade Federal de Alfenas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla Silva","family":"D\u00e2maso","sequence":"additional","affiliation":[{"name":"Universidade Federal de Alfenas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Felipe Leomil","family":"Coelho","sequence":"additional","affiliation":[{"name":"Universidade Federal de Alfenas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta Ribeiro","family":"Silva","sequence":"additional","affiliation":[{"name":"Universidade Federal de Alfenas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric Batista","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Universidade Federal de Alfenas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Rita","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Universidade Federal de Alfenas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoilo Pires de","family":"Camargo","sequence":"additional","affiliation":[{"name":"Universidade Federal do Estado de S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u00e2nia Regina Gr\u00e3o","family":"Velloso","sequence":"additional","affiliation":[{"name":"Universidade Federal do Esp\u00edrito Santo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Cosme Cotta","family":"Malaquias","sequence":"additional","affiliation":[{"name":"Universidade Federal de Alfenas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/myc.12017","article-title":"Important aspects of oral paracoccidioidomycosis: a literature review","volume":"56","author":"Abreu e Silva 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Infect"},{"key":"ref5","first-page":"2013","article-title":"Epidemiological study of paracoccidioidomycosis and histoplasmosis in a suburb of San F\u00e9lix city, Bol\u00edvar State, Venezuela","volume":"50","author":"Cerme\u00f1o J","year":"2009","journal-title":"Invest Clin"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/j.1365-3156.2004.01376.x","article-title":"Histoplasmine and paracoccidiodine epidemiological study in Upata, Bol\u00edvar State, Venezuela","volume":"10","author":"Cerme\u00f1o JR","year":"2005","journal-title":"Trop Med Int Health"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1590\/S0102-311X2003000100027","article-title":"Associa\u00e7\u00e3o entre tabagismo e paracoccidioidomicose: um estudo de caso-controle no Estado do Esp\u00edrito Santo, Brasil","volume":"19","author":"dos Santos WA","year":"2003","journal-title":"Cad Sa\u00fade P\u00fablica"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1590\/S0036-46651998000300005","article-title":"Epidemiologic surveys of histoplasmin and paracoccidioidin sensitivity in Brazil","volume":"40","author":"Fava SC","year":"1998","journal-title":"Rev Inst Med Trop S\u00e3o Paulo"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1590\/S0037-86822005000200014","article-title":"Inqu\u00e9rito epidemiol\u00f3gico sobre a paracoccidioidomicose utilizando a gp43 em dois munic\u00edpios do noroeste do Paran\u00e1, Brasil","volume":"38","author":"Fornajeiro N","year":"2005","journal-title":"Rev Soc Bras Med Trop"},{"issue":"(9)","key":"ref10","doi-asserted-by":"crossref","first-page":"e300","DOI":"10.1371\/journal.pntd.0000300","article-title":"The neglected tropical diseases of Latin America and the Caribbean: a review of disease burden and distribution and a road map for control and elimination","volume":"2","author":"Hotez PJ","year":"2008","journal-title":"PLoS Negl Trop Dis"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"82","DOI":"10.4269\/ajtmh.2004.71.82","article-title":"Paracoccidioidomycosis: an epidemiologic survey in a pediatric population from the Brazilian Amazon using skin tests","volume":"71","author":"Kalmar EM","year":"2004","journal-title":"Am J Trop Med Hyg"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1080\/mmy.38.3.225.229","article-title":"Production of IFN-gamma is impaired in patients with paracoccidioidomycosis during active disease and is restored after clinical remission","volume":"38","author":"Karhawi AS","year":"2000","journal-title":"Med Mycol"},{"key":"ref13","series-title":"Tratado de micologia m\u00e9dica Lacaz. 9<sup>a<\/sup> ed","first-page":"639","volume-title":"Paracoccidioidomicose","author":"Lacaz CS","year":"2002"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0140-6736(09)61749-9","article-title":"Programmes, partnerships, and governance for elimination and control of neglected tropical diseases","volume":"375","author":"Liese B","year":"2010","journal-title":"Lancet"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.cyto.2005.07.006","article-title":"Kinetics of cytokines and chemokines gene expression distinguishes <em>Paracoccidioides brasiliensis<\/em> infection from disease","volume":"32","author":"Mamoni RL","year":"2005","journal-title":"Cytokine"},{"key":"ref16","first-page":"173","article-title":"<em>Paracoccidioides brasiliensis<\/em> infection in a subtropical region with important environmental changes","volume":"92","author":"Mangiaterra ML","year":"1999","journal-title":"Bull Soc Pathol Exot"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s11046-013-9656-x","article-title":"Evaluation of <em>Paracoccidioides brasiliensis<\/em> infection by gp 43 intradermal test in rural settlements in Central-West Brazil","volume":"176","author":"Marques AP","year":"2013","journal-title":"Mycopathologia"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.clindermatol.2012.01.006","article-title":"Paracoccidioidomycosis","volume":"30","author":"Marques SA","year":"2012","journal-title":"Clin Dermatol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1590\/S0037-86822010000400034","article-title":"Paracoccidioidomycosis: the dimension of the problem of a neglected disease","volume":"43","author":"Martinez R","year":"2010","journal-title":"Rev Soc Bras Med Trop"},{"key":"ref20","first-page":"11","article-title":"Paracoccidioidomicose: hist\u00f3rico, etiologia, epidemiologia, patog\u00eanese, formas cl\u00ednicas, diagn\u00f3stico laboratorial e ant\u00edgenos","volume":"5","author":"Moreira APV","year":"2008","journal-title":"Bol Epidemiol Paul"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S1286-4579(01)01521-0","article-title":"Cytokines and lymphocyte proliferation in juvenile and adult forms of paracoccidioidomycosis: comparison with infected and non-infected controls","volume":"4","author":"Oliveira SJ","year":"2002","journal-title":"Microbes Infect"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1080\/mmy.40.5.493.499","article-title":"Inhibition of <em>Paracoccidioides brasiliensis<\/em> by pesticides: is this a partial explanation for the difficulty in isolating this fungus from the soil?","volume":"40","author":"Ono MA","year":"2002","journal-title":"Med Mycol"},{"key":"ref23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0010757","article-title":"Immunological basis for the gender differences in murine <em>Paracoccidioides brasiliensis<\/em> infection","volume":"5","author":"Pinzan CF","year":"2010","journal-title":"PLoS One"},{"key":"ref24","series-title":"The R Project for Statistical Computing","first-page":"20","year":"2004"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s12281-012-0114-x","article-title":"Paracoccidioidomycosis: Latin America's own fungal disorder","volume":"6","author":"Restrepo A","year":"2012","journal-title":"Curr Fungal Infect Rep"},{"key":"ref26","series-title":"Essentials of clinicals mycology","first-page":"367","volume-title":"Paracoccidioidomycosis","author":"Restrepo A","year":"2011","edition":"2nd ed"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1080\/mmy.39.3.233.241","article-title":"The habitat of <em>Paracoccidioides brasiliensis<\/em>: how far from solving the riddle?","volume":"39","author":"Restrepo A","year":"2001","journal-title":"Med Mycol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1128\/IAI.46.2.346-353.1984","article-title":"Estrogens inhibit mycelium-to-yeast transformation in the fungus <em>Paracoccidioides brasiliensis<\/em>: implications for resistance of females to paracoccidioidomycosis","volume":"46","author":"Restrepo A","year":"1984","journal-title":"Infect Immun"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1128\/IAI.56.3.711-713.1988","article-title":"Inhibition by estrogens of conidium-to-yeast conversion in the fungus <em>Paracoccidioides brasiliensis<\/em>","volume":"56","author":"Salazar ME","year":"1988","journal-title":"Infect Immun"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1080\/02681219680000261","article-title":"<em>Paracoccidioides brasiliensis<\/em>-gp43 used as paracoccidioidin","volume":"34","author":"Saraiva EC","year":"1996","journal-title":"J Med Vet Mycol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s11046-011-9495-6","article-title":"Paracoccidioidal infection in HIV patients at an endemic area of paracoccidioidomycosis in Brazil","volume":"173","author":"Sarti EC","year":"2012","journal-title":"Mycopathologia"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1128\/CMR.00062-10","article-title":"Hormones and the resistance of women to paracoccidioidomycosis","volume":"24","author":"Shankar J","year":"2011","journal-title":"Clin Microbiol Rev"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1590\/S0037-86822006000300017","article-title":"Consenso em paracoccidioidomicose","volume":"39","author":"Shikanai-Yasuda MA","year":"2006","journal-title":"Rev Soc Bras Med Trop"},{"key":"ref34","first-page":"294","article-title":"Inqu\u00e9rito epidemiol\u00f3gico com paracoccidioidina e histoplasmina em \u00e1rea agr\u00edcola de caf\u00e9 em Ibi\u00e1, Minas Gerais, Brasil","volume":"15","author":"Silva-Vergara ML","year":"1998","journal-title":"Rev Iberoam Micol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1128\/IAI.51.1.199-203.1986","article-title":"Estradiol-binding proteins from mycelial and yeast-form cultures of <em>Paracoccidioides brasiliensis<\/em>","volume":"51","author":"Stover EP","year":"1986","journal-title":"Infect Immun"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.ympev.2009.04.005","article-title":"Phylogenetic analysis reveals a high level of speciation in the <em>Paracoccidioides<\/em> genus","volume":"52","author":"Teixeira MM","year":"2009","journal-title":"Mol Phylogenet Evol"},{"key":"ref37","first-page":"383","article-title":"Histoplasmosis and paracoccidioidomycosis in northwestern Argentina. III. Epidemiological survey in Vipos, La Toma, and Choromoro - Trancas, Tucum\u00e1n, Argentina","volume":"15","author":"van Gelderen de Komaid A","year":"1999","journal-title":"Eur J Epidemiol"}],"container-title":["Revista do Instituto de Medicina Tropical de S\u00e3o Paulo"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/rimtsp\/v56n4\/0036-4665-rimtsp-56-04-281.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,22]],"date-time":"2020-08-22T17:15:35Z","timestamp":1598116535000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0036-46652014000400281&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["S0036-46652014000400281"],"URL":"https:\/\/doi.org\/10.1590\/s0036-46652014000400002","relation":{},"ISSN":["0036-4665"],"issn-type":[{"value":"0036-4665","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7]]}}}