{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T03:27:37Z","timestamp":1782185257025,"version":"3.54.5"},"reference-count":28,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Inst. Med. trop. S. Paulo"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:p>Introduction: Urinary tract infection (UTI) has a high incidence and recurrence, therefore, treatment is empirical in the majority of cases. Objectives: The aim of this study was to analyze the urine cultures performed at a secondary hospital, during two periods, 2005-2006 and 2010-2011, and to estimate the microbial resistance. Patients and methods: We analyzed 11,943 aerobic urine cultures according to basic demographic data and susceptibility to antibiotics in accordance with the Clinical and Laboratory Standards Institute (CLSI) for Vitek 1 and 2. Results: Most of our cohort consisted of young adult females that were seen at the Emergency Department. E. coli was the most frequent (70.2%) among the 75 species isolated. Resistance of all isolates was \u2265 20% for trimethoprim\/sulfamethoxazole (TMP\/SMX), norfloxacin, nitrofurantoin, cefazolin and nalidixic acid. Although E. coli was more susceptible (resistance \u2265 20% for TMP\/SMX and nalidixic acid) among all of the isolates, when classified by the number and percentage of antibiotic resistance. Global resistance to fluoroquinolones was approximately 12%. Risk factors for E. coli were female gender and an age less than 65 years. Men and patients older than 65 years of age, presented more resistant isolates. Extended spectrum beta-lactamases (ESBL) were identified in 173 out of 5,722 Gram-negative isolates (3.0%) between 2010 and 2011. Conclusion: E. coli was the most frequent microbe isolated in the urine cultures analyzed in this study. There was a significant evolution of bacterial resistance between the two periods studied. In particular, the rise of bacterial resistance to fluoroquinolones was concerning.<\/jats:p>","DOI":"10.1590\/s0036-46652014000400009","type":"journal-article","created":{"date-parts":[[2014,7,28]],"date-time":"2014-07-28T13:21:55Z","timestamp":1406553715000},"page":"313-324","source":"Crossref","is-referenced-by-count":20,"title":["SUSCEPTIBILITY TO ANTIBIOTICS IN URINARY TRACT INFECTIONS IN A SECONDARY CARE SETTING FROM 2005-2006 AND 2010-2011, IN S\u00c3O PAULO, BRAZIL: DATA FROM 11,943 URINE CULTURES"],"prefix":"10.1590","volume":"56","author":[{"given":"\u00c9rique Jos\u00e9 Peixoto De","family":"Miranda","sequence":"first","affiliation":[{"name":"University of S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerson Sobrinho Salvador De","family":"Oliveira","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fel\u00edcio Lopes","family":"Roque","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00edlvia Regina Dos","family":"Santos","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Diaz","family":"Olmos","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo School of Medicine,  Brazil; Internal Medicine Division of the University Hospital of the University of S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Andrade","family":"Lotufo","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo School of Medicine,  Brazil; University of S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1590\/S0074-02762006000700006","article-title":"Increased resistance to first-line agents among bacterial pathogens isolated from urinary tract infections in Latin America: time for local guidelines?","volume":"101","author":"Andrade SS","year":"2006","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref2","first-page":"51","article-title":"Infec\u00e7\u00e3o do trato urin\u00e1rio: compara\u00e7\u00e3o entre o perfil de susceptibilidade e a terapia emp\u00edrica com antimicrobianos","volume":"38","author":"Bail L","year":"2006","journal-title":"Rev Bras Anal Clin"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1001\/archinte.1959.00270080034004","article-title":"Single disc antibiotic sensitivity testing of staphylococci; an analysis of technique and results","volume":"104","author":"Bauer AW","year":"1959","journal-title":"Arch Intern Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1590\/S1676-24442009000600003","article-title":"Infec\u00e7\u00f5es do trato urin\u00e1rio em pacientes n\u00e3o hospitalizados: etiologia e padr\u00e3o de resist\u00eancia aos antimicrobianos","volume":"45","author":"Braoios A","year":"2009","journal-title":"J Bras Patol Med Lab"},{"key":"ref5","series-title":"Normas de desempenho para teste de sensibilidade antimicrobiana: 15\u00b0 suplemento informativo. 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