{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T01:50:38Z","timestamp":1695606638842},"reference-count":23,"publisher":"FapUNIFESP (SciELO)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Inst. Med. trop. S. Paulo"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:p>This study aimed to determine the existence of blood vessels within ganglia of the myenteric plexus of the human esophagus and colon. At necropsy, 15 stillborns, newborns and children up to two years of age, with no gastrointestinal disorders, were examined. Rings of the esophagus and colon were analyzed and then fixed in formalin and processed for paraffin. Histological sections were stained by hematoxylin-eosin, Giemsa and immunohistochemistry for the characterization of endothelial cells, using antibodies for anti-factor VIII and CD31. Blood vessels were identified within the ganglia of the myenteric plexus of the esophagus, and no blood vessels were found in any ganglia of the colon. It was concluded that the ganglia of the myenteric plexus of the esophagus are vascularized, while the ganglia of the colon are avascular. Vascularization within the esophageal ganglia could facilitate the entrance of infectious agents, as well as the development of inflammatory responses (ganglionitis) and denervation, as found in Chagas disease and idiopathic achalasia. This could explain the higher frequency of megaesophagus compared with megacolon.<\/jats:p>","DOI":"10.1590\/s0036-46652014000600013","type":"journal-article","created":{"date-parts":[[2014,10,22]],"date-time":"2014-10-22T23:13:57Z","timestamp":1414019637000},"page":"529-532","source":"Crossref","is-referenced-by-count":1,"title":["BLOOD VESSELS IN GANGLIA IN HUMAN ESOPHAGUS MIGHT EXPLAIN THE HIGHER FREQUENCY OF MEGAESOPHAGUS COMPARED WITH MEGACOLON"],"prefix":"10.1590","volume":"56","author":[{"given":"Sheila Jorge","family":"Adad","sequence":"first","affiliation":[{"name":"Universidade Federal do Triangulo Mineiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata Margarida","family":"Etchebehere","sequence":"additional","affiliation":[{"name":"Universidade Federal do Triangulo Mineiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro Adad","family":"Jammal","sequence":"additional","affiliation":[{"name":"Universidade Federal do Triangulo Mineiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","author":"Adad SJ","year":"1989"},{"key":"ref2","author":"Adad SJ","year":"1996"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1590\/S0036-46651991000600004","article-title":"Contribui\u00e7\u00e3o ao estudo da anatomia patol\u00f3gica do megaes\u00f3fago chag\u00e1sico","volume":"33","author":"Adad SJ","year":"1991","journal-title":"Rev Inst Med Trop Sao Paulo"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1007\/s004280000319","article-title":"Neuron count reevaluation in the myenteric plexus of chagasic megacolon after morphometric neuron analysis","volume":"438","author":"Adad SJ","year":"2001","journal-title":"Virchows Arch"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/S0016-5085(84)80120-1","article-title":"Comparative anatomy of the myenteric plexus of the distal colon in eight mammals","volume":"86","author":"Christensen J","year":"1984","journal-title":"Gastroenterology"},{"key":"ref6","first-page":"9","article-title":"Incidence of symptomatic megacolon in patients with chagasic megaesophagus","volume":"38","author":"Corsi PR","year":"1992","journal-title":"Rev Assoc Med Bras"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/BF01072928","article-title":"Esophageal ganglia and smooth muscle in the elderly","volume":"23","author":"Eckardt VF","year":"1978","journal-title":"Am J Dig Dis"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0074-7696(08)61662-9","article-title":"Innervation of the gastrointestinal tract","volume":"59","author":"Gabella G","year":"1979","journal-title":"Int Rev Cytol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"S59","DOI":"10.1016\/0165-1838(90)90103-P","article-title":"On the plasticity of form and structure of enteric ganglia","volume":"30","author":"Gabella G","year":"1990","journal-title":"J Auton Nerv Syst"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/BF01148318","article-title":"Size of neurons and glial cells in the enteric ganglia of mice, guinea-pigs, rabbits and sheep","volume":"13","author":"Gabella G","year":"1984","journal-title":"J Neurocytol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1002\/cne.901800305","article-title":"Properties of the enteric nervous system: limitation of acess of intravascular macromolecules to the myenteric plexus and muscularis externa","volume":"180","author":"Gershon MD","year":"1978","journal-title":"J Comp Neurol"},{"issue":"(Pt 2)","key":"ref12","first-page":"223","article-title":"Histological and histochemical observations on the myenteric and submucous plexuses of mammals","volume":"102","author":"Gunn M","year":"1968","journal-title":"J Anat"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1002\/(SICI)1097-0029(19961001)35:2<122::AID-JEMT3>3.0.CO;2-S","article-title":"Vascular permeability in the peripheral autonomic and somatic nervous systems: controversial aspects and comparisons with the blood-brain barrier","volume":"35","author":"Kiernan JA","year":"1996","journal-title":"Microsc Res Tech"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0065-308X(08)60472-8","article-title":"Chagas'disease and Chagas'syndromes: the pathology of American trypanosomiasis","volume":"6","author":"Koberle F","year":"1968","journal-title":"Adv Parasitol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/0016-5085(89)91619-3","article-title":"Human myenteric plexus: confirmation of unfamiliar structures in adults and neonates","volume":"96","author":"Kumar D","year":"1989","journal-title":"Gastroenterology"},{"key":"ref16","first-page":"55","article-title":"A morpho-quantitative study of the myenteric ganglia throughout the human digestive tract","volume":"53","author":"Liberti EA","year":"1998","journal-title":"Rev Hosp Clin Fac Med S Paulo"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"223","DOI":"10.5603\/FM.2013.0037","article-title":"Morphometric analysis of muscularis proper and myenteric plexus of the normal human oesophagus. Age related changes","volume":"72","author":"Milosavljevic Z","year":"2013","journal-title":"Folia Morphol (Warsz)"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.autneu.2007.04.005","article-title":"Innervation of the gastrointestinal tract: patterns of aging","volume":"136","author":"Phillips RJ","year":"2007","journal-title":"Auton Neurosci"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1590\/S0037-86821968000600005","article-title":"Caso de doen\u00e7a de Chagas observado desde o per\u00edodo inicial da infec\u00e7\u00e3o, com aparecimento precoce de megaes\u00f4fago e megacolo","volume":"2","author":"Rassi A","year":"1968","journal-title":"Rev Soc Bras Med Trop"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1590\/S0037-86822012000200026","article-title":"Advanced megaesophagus (Group III) secondary to vector-borne Chagas disease in a 20-month-old infant","volume":"45","author":"Rassi A","year":"2012","journal-title":"Rev Soc Bras Med Trop"},{"key":"ref21","series-title":"Storino R, Milei J. Enfermedad de Chagas","first-page":"331","volume-title":"Megaformaciones digestivas","author":"Rezende JM","year":"1994"},{"key":"ref22","first-page":"178","article-title":"Les\u00f5es do sistema nervoso aut\u00f4nomo simp\u00e1tico do camundongo na fase aguda da tripanossomose cruzi experimental. Estudo ao microsc\u00f3pio \u00f3ptico e eletr\u00f4nico","volume":"21","author":"Tafuri WL","year":"1979","journal-title":"Rev Inst Med Trop Sao Paulo"},{"key":"ref23","first-page":"7","article-title":"Quantitative study of ganglion neurons of the human esophagus in relation to age","volume":"27","author":"Wada MLF","year":"1981","journal-title":"Rev Goiana Med"}],"container-title":["Revista do Instituto de Medicina Tropical de S\u00e3o Paulo"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/rimtsp\/v56n6\/0036-4665-rimtsp-56-06-529.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T02:37:55Z","timestamp":1598409475000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0036-46652014000600529&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["S0036-46652014000600529"],"URL":"https:\/\/doi.org\/10.1590\/s0036-46652014000600013","relation":{},"ISSN":["0036-4665"],"issn-type":[{"value":"0036-4665","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12]]}}}