{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T14:28:10Z","timestamp":1749565690086},"reference-count":24,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Inst. Med. trop. S. Paulo"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:p>SUMMARY Sporothrix schenckiiwas reclassified as a complex encompassing six cryptic species, which calls for the reassessment of clinical and epidemiological data of these new species. We evaluated the susceptibility of Sporothrix albicans (n = 1) , S. brasiliensis (n = 6) , S. globosa (n = 1), S. mexicana(n = 1) and S. schenckii(n = 36) to terbinafine (TRB) alone and in combination with itraconazole (ITZ), ketoconazole (KTZ), and voriconazole (VRZ) by a checkerboard microdilution method and determined the enzymatic profile of these species with the API-ZYM kit. Most interactions were additive (27.5%, 32.5% and 5%) or indifferent (70%, 50% and 52.5%) for TRB+KTZ, TRB+ITZ and TRB+VRZ, respectively. Antagonisms were observed in 42.5% of isolates for the TRB+VRZ combination. Based on enzymatic profiling, the Sporothrix schenckii strains were categorized into 14 biotypes. Leucine arylamidase (LA) activity was observed only for S. albicans and S. mexicana. The species S. globosaand S. mexicanawere the only species without \u03b2-glucosidase (GS) activity. Our results may contribute to a better understanding of virulence and resistance among species of the genus Sporothrixin further studies.<\/jats:p>","DOI":"10.1590\/s0036-46652015000400003","type":"journal-article","created":{"date-parts":[[2015,9,30]],"date-time":"2015-09-30T00:17:54Z","timestamp":1443572274000},"page":"289-294","source":"Crossref","is-referenced-by-count":10,"title":["Sporothrix schenckii COMPLEX: SUSCEPTIBILITIES TO COMBINED ANTIFUNGAL AGENTS AND CHARACTERIZATION OF ENZYMATIC PROFILES"],"prefix":"10.1590","volume":"57","author":[{"given":"Daniele Carvalho","family":"OLIVEIRA","sequence":"first","affiliation":[{"name":"Universidade Federal de Santa Maria, Brazil; Universidade Federal de Santa Maria, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c9rico Silva de","family":"LORETO","sequence":"additional","affiliation":[{"name":"Universidade Federal de Santa Maria, Brazil; Universidade Federal de Santa Maria, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00e9bora Alves Nunes","family":"MARIO","sequence":"additional","affiliation":[{"name":"Universidade Federal de Santa Maria, Brazil; Universidade Federal de Santa Maria, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo G. Markus","family":"LOPES","sequence":"additional","affiliation":[{"name":"Universidade Federal de Santa Maria, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise Vignolles","family":"NEVES","sequence":"additional","affiliation":[{"name":"Universidade Federal de Santa Maria, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta Pires da","family":"ROCHA","sequence":"additional","affiliation":[{"name":"Universidade Federal de Santa Maria, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janio Morais","family":"SANTURIO","sequence":"additional","affiliation":[{"name":"Universidade Federal de Santa Maria, Brazil; Universidade Federal de Santa Maria, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sydney Hartz","family":"ALVES","sequence":"additional","affiliation":[{"name":"Universidade Federal de Santa Maria, Brazil; Universidade Federal de Santa Maria, Brazil; Universidade Federal de Santa Maria, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.1128\/AAC.01176-06","article-title":"In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods","volume":"51","author":"Alvarado-Ramirez E","year":"2007","journal-title":"Antimicrob Agents Chemother"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1590\/S0037-86822010000500010","article-title":"Sporothrix schenckii associated with armadillo hunting in Southern Brazil: epidemiological and antifungal susceptibility profiles","volume":"43","author":"Alves SH","year":"2010","journal-title":"Rev Soc Bras Med Trop"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1111\/j.1469-0691.2009.02824.x","article-title":"Different virulence levels of the species of Sporothrix in a murine 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