{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:18:02Z","timestamp":1779236282185,"version":"3.51.4"},"reference-count":29,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Inst. Med. trop. S. Paulo"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:p>SUMMARY The role of trace elements in dengue virulence is not yet known. The present study assessed the serum levels of two micronutrients, copper and iron, in cases of dengue fever. The study involved 96 patients of whom 48 had either severe or non-severe forms of dengue (with and without warning signs), and the remaining 48 were patients with other febrile illnesses (OFI), used as controls. Serum levels of copper and iron were evaluated at admission and by the time of defervescence using commercially available kits. At admission, no difference in the level of serum copper was observed between cases and controls. In the group of dengue cases, the copper level was found to be significantly decreased in severe and non-severe cases with warning signs, compared to non-severe cases without warning signs. In contrast, by the time of defervescence the copper level was found to be increased in all dengue cases compared to OFI controls, but no difference was observed among dengue cases. Unlike OFI controls, dengue cases showed an increasing pattern of copper levels from admission until defervescence. On the other hand, no such significant differences were observed in the serum level of iron in the clinical groups, except for a decreased iron level found in severe cases, compared to non-severe dengue without warning signs. The results show that copper is associated with dengue severity and this finding emphasizes the need to investigate the involvement of trace elements in disease severity so as to improve the prognosis of dengue.<\/jats:p>","DOI":"10.1590\/s0036-46652015000400007","type":"journal-article","created":{"date-parts":[[2015,9,30]],"date-time":"2015-09-30T00:17:50Z","timestamp":1443572270000},"page":"315-320","source":"Crossref","is-referenced-by-count":19,"title":["SERUM LEVELS OF COPPER AND IRON IN DENGUE FEVER"],"prefix":"10.1590","volume":"57","author":[{"given":"Rajendiran","family":"SOUNDRAVALLY","sequence":"first","affiliation":[{"name":"Jawaharlal Institute of Postgraduate Medical Education and Research, South India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"SHERIN","sequence":"additional","affiliation":[{"name":"Jawaharlal Institute of Postgraduate Medical Education and Research, South 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pathogenicity","volume":"20","author":"Beck MA","year":"2001","journal-title":"J Am Coll Nutr"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nature12060","article-title":"The global distribution and burden of dengue","volume":"496","author":"Bhatt S","year":"2013","journal-title":"Nature"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"260","DOI":"10.4103\/0019-5359.107028","article-title":"Dengue epidemiology in Thanjavur and Trichy district, Tamilnadu - Jan 2011-Dec 2011","volume":"65","author":"Bhuvaneswari CK","year":"2011","journal-title":"Indian J Med Sci"},{"key":"ref4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0001760","article-title":"Refining the global spatial limits of dengue virus transmission by evidence-based consensus","volume":"6","author":"Brady OJ","year":"2012","journal-title":"PLOS Negl Trop Dis"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1365-2125.1991.tb05525.x","article-title":"Iron supplements: a common cause of drug interactions","volume":"31","author":"Campbell NR","year":"1991","journal-title":"Br J Clin Pharmacol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"6212","DOI":"10.3748\/wjg.v12.i38.6212","article-title":"Relationship between antioxidant capacity and oxidative stress in children with acute hepatitis A","volume":"12","author":"Cemek M","year":"2006","journal-title":"World J Gastroenterol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jinf.2004.08.012","article-title":"Serum copper and zinc concentrations in patients with chronic hepatitis B","volume":"51","author":"Cesur S","year":"2005","journal-title":"J Infect"},{"key":"ref8","first-page":"1536","article-title":"Viral infections and trace elements : a complex interaction","volume":"87","author":"Chaturvedi UC","year":"2004","journal-title":"Curr Sci"},{"key":"ref9","first-page":"390","article-title":"Copper and metallothioneins in cancer cells","volume":"58","author":"Florianczyk B","year":"2003","journal-title":"Ann Univ Mariae Curie Sk\u0142odowska Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0035-9203(02)90287-7","article-title":"Serum ferritin, alpha-tocopherol, beta-carotene and retinol levels in lymphatic filariasis","volume":"96","author":"Friis H","year":"2002","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/sj.ejcn.1600546","article-title":"Micronutrients and HIV infection: a review","volume":"52","author":"Friis H","year":"1998","journal-title":"Eur J Clin Nutr"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0166-3542(99)00040-6","article-title":"Inhibition of HIV-1 infection by zinc group metal compounds","volume":"43","author":"Haraguchi Y","year":"1999","journal-title":"Antiviral Res"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1046\/j.1440-1746.2000.02199.x","article-title":"Accumulation of copper in the liver and hepatic injury in chronic hepatitis C","volume":"15","author":"Hatano R","year":"2000","journal-title":"J Gastroenterol Hepatol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jviromet.2006.08.003","article-title":"Rapid detection, serotyping and quantitation of dengue viruses by TaqMan real-time one-step RT-PCR","volume":"138","author":"Kong YY","year":"2006","journal-title":"J Virol Methods"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1385\/BTER:109:1:015","article-title":"Selenium, iron, copper, and zinc levels and copper-to-zinc ratios in serum of patients at different stages of viral hepatic diseases","volume":"109","author":"Lin CC","year":"2006","journal-title":"Biol Trace Elem Res"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1054\/clnu.2001.0527","article-title":"The relationship between reduced vitamin antioxidant concentrations and the systemic inflammatory response in patients with common solid tumours","volume":"21","author":"McMillan DC","year":"2002","journal-title":"Clin Nutr"},{"key":"ref17","first-page":"339","article-title":"Dengue fever caused by dengue virus serotype-3 (subtype-III) in a rural area of Madurai district, Tamil Nadu","volume":"132","author":"Paramasivan R","year":"2010","journal-title":"Indian J Med Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.jtemb.2011.07.001","article-title":"The role of trace elements on hepatitis virus infections: a review","volume":"25","author":"Rashed MN","year":"2011","journal-title":"J Trace Elem Med Biol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/S0140-6736(97)12483-7","article-title":"Dengue and dengue haemorrhagic fever","volume":"352","author":"Rigau-P\u00e9rez JG","year":"1998","journal-title":"Lancet"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.trstmh.2005.10.007","article-title":"Pathogenesis of liver involvement during dengue viral infections","volume":"100","author":"Seneviratne SL","year":"2006","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1111\/j.1530-0277.1994.tb00067.x","article-title":"Ethanol consumption and early murine retrovirus infection influence liver, heart, and muscle levels of iron, zinc, and copper in C57BL\/6 mice","volume":"18","author":"Shahbazian LM","year":"1994","journal-title":"Alcohol Clin Exp Res"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ijid.2013.09.022","article-title":"Association between proinflammatory cytokines and lipid peroxidation in patients with severe dengue disease around defervescence","volume":"18","author":"Soundravally R","year":"2014","journal-title":"Int J Infect Dis"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1080\/09537100802155284","article-title":"Oxidative stress in severe dengue viral infection: association of thrombocytopenia with lipid peroxidation","volume":"19","author":"Soundravally R","year":"2008","journal-title":"Platelets"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.actatropica.2008.03.001","article-title":"Oxidative stress induced changes in plasma protein can be a predictor of imminent severe dengue infection","volume":"106","author":"Soundravally R","year":"2008","journal-title":"Acta 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