{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T12:54:06Z","timestamp":1773924846322,"version":"3.50.1"},"reference-count":17,"publisher":"FapUNIFESP (SciELO)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Soc. Bras. Med. Trop."],"published-print":{"date-parts":[[1997,4]]},"abstract":"<jats:p>Os autores descrevem dezoito casos de histoplasmose observados em pacientes imunodeprimidos, sendo 17 com SIDA e um associado \u00e0 cirrose hep\u00e1tica alco\u00f3lica. O diagn\u00f3stico da histoplasmose foi obtido atrav\u00e9s do isolamento do fungo em cultura de LCR, sangue e medula \u00f3ssea ou por exame histopatol\u00f3gico obtido por bi\u00f3psia ou necropsia. A idade m\u00e9dia dos pacientes foi de 35,8 anos, sendo 13 (72,2%) do sexo masculino. Em geral, a doen\u00e7a mostrou-se disseminada com acometimento por ordem de freq\u00fc\u00eancia de: pele (38,8%), medula \u00f3ssea (27,7%), mucosa nasofaringeana (22,2%), pulm\u00e3o (22,2%), c\u00f3lon (11,1%), SNC (5,5%) e es\u00f4fago (5,5%). Adenomegalia (50%),hepatomegalia (77,7%) e esplenomegalia (61,1%) tamb\u00e9m foram observados com muita frequ\u00eancia. Hematologicamente observou-se mais comumente pancitopenia (33,3%). Onze dos 18 pacientes receberam tratamento, sendo 9 com anfotericina B e 2 com itraconazol; 8 obtiveram boa resposta cl\u00ednica e todos receberam terapia de manuten\u00e7\u00e3o com anfotericina B ou derivado triaz\u00f3lico. Este trabalho enfatiza a import\u00e2ncia desta micose em pacientes imunodeprimidos, particularmente em pacientes com SIDA onde a infec\u00e7\u00e3o tende a acometer o sistema macrof\u00e1gico-linf\u00f3ide e o tegumento cut\u00e2neo.<\/jats:p>","DOI":"10.1590\/s0037-86821997000200006","type":"journal-article","created":{"date-parts":[[2005,4,26]],"date-time":"2005-04-26T16:43:23Z","timestamp":1114533803000},"page":"119-124","source":"Crossref","is-referenced-by-count":32,"title":["Histoplasmose em pacientes imunodeprimidos: estudo de 18 casos observados em Uberl\u00e2ndia, MG"],"prefix":"10.1590","volume":"30","author":[{"given":"A\u00e9rcio S.","family":"Borges","sequence":"first","affiliation":[{"name":"Universidade Federal de Uberl\u00e2ndia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo Sim\u00e3o","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Universidade Federal de Uberl\u00e2ndia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco T\u00falio A.","family":"Silvestre","sequence":"additional","affiliation":[{"name":"Universidade Federal de Uberl\u00e2ndia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9rgio de A.","family":"Nishioka","sequence":"additional","affiliation":[{"name":"Universidade Federal de Uberl\u00e2ndia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ademir","family":"Rocha","sequence":"additional","affiliation":[{"name":"Universidade Federal de Uberl\u00e2ndia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1001\/jama.258.9.1143","article-title":"Revision of the CDC surveillance case definition of acquired immunodeficiency syndrome","volume":"258","year":"1987","journal-title":"The Journal of the American Medical Association"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0002-9343(63)90163-3","article-title":"Histoplasmosis of the central nervous system: Report of two cases and review of literature","volume":"35","author":"Cooper RA","year":"1963","journal-title":"The American Journal of Medicine"},{"key":"ref3","author":"Dickinson DJ","year":"1992"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1097\/00000478-199302000-00002","article-title":"Cutaneous manifestations of histoplasmosis in the AIDS","volume":"17","author":"Eidbo J","year":"1993","journal-title":"The American Journal of Surgical Pathology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00005792-198001000-00001","article-title":"Disseminated histoplasmosis: clinical and pathologic correlations","volume":"59","author":"Goodwin RA","year":"1980","journal-title":"Medicine (Baltimore)","ISSN":"https:\/\/id.crossref.org\/issn\/0025-7974","issn-type":"print"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/BF02049996","article-title":"Colonic histoplasmosis in Acquired Immunodeficiency Syndrome","volume":"34","author":"Grahans BD","year":"1991","journal-title":"Diseases of C\u00f3lon and Rectum"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1128\/JCM.30.8.2104-2107.1992","article-title":"Typing of Histoplasma capsulatum by restric ion fragment length polymorphisms in a nuclear gene","volume":"30","author":"Keath EJ","year":"1992","journal-title":"Journal of Clinical Microbiology","ISSN":"https:\/\/id.crossref.org\/issn\/0095-1137","issn-type":"print"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/BF00436416","article-title":"Histoplasmosis in individuals with Acquired Immune Syndrome (AIDS): Report of six cases with cutaneous - 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