{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,13]],"date-time":"2024-07-13T11:50:32Z","timestamp":1720871432160},"reference-count":20,"publisher":"FapUNIFESP (SciELO)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Soc. Bras. Med. Trop."],"published-print":{"date-parts":[[2000,4]]},"abstract":"<jats:p>Doze pacientes com idades entre 7 a 12 anos, na forma indeterminada da doen\u00e7a de Chagas, com sorologia e xenodiagn\u00f3stico positivos, receberam tratamento espec\u00edfico. Dois pacientes tomaram 7mg\/kg de nifurtimox durante 60 e 90 dias e 10 usaram 5-7mg\/kg de benznidazol durante 60 dias. A evolu\u00e7\u00e3o cl\u00ednica foi verificada atrav\u00e9s de exame cl\u00ednico, eletrocardiograma, exame radiol\u00f3gico contrastado do es\u00f4fago. Ap\u00f3s o tratamento somente uma (8,3%) paciente apresentou todos os exames negativos. Oito deles foram avaliados ap\u00f3s oito anos do tratamento e 4 acompanhados durante 20 anos. Sete (58,4%) permaneceram na forma indeterminada e 4 (33,3%) chag\u00e1sicos progrediram clinicamente para cardiopatia grau II e\/ou esofagopatia, apesar do tratamento precoce. S\u00e3o necess\u00e1rios estudos com maior n\u00famero de crian\u00e7as na fase indeterminada e acompanhamento a longo prazo para se estabelecer a influ\u00eancia do tratamento espec\u00edfico na evolu\u00e7\u00e3o da doen\u00e7a de Chagas.<\/jats:p>","DOI":"10.1590\/s0037-86822000000200006","type":"journal-article","created":{"date-parts":[[2005,4,26]],"date-time":"2005-04-26T16:46:51Z","timestamp":1114534011000},"page":"191-196","source":"Crossref","is-referenced-by-count":20,"title":["Avalia\u00e7\u00e3o do tratamento espec\u00edfico para o Trypanosoma cruzi em crian\u00e7as, na evolu\u00e7\u00e3o da fase indeterminada"],"prefix":"10.1590","volume":"33","author":[{"given":"Celeste A.N.","family":"Silveira","sequence":"first","affiliation":[{"name":"Universidade de Bras\u00edlia, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edwin","family":"Castillo","sequence":"additional","affiliation":[{"name":"Universidade de Bras\u00edlia, 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