{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T18:04:17Z","timestamp":1648663457997},"reference-count":30,"publisher":"FapUNIFESP (SciELO)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Soc. Bras. Med. Trop."],"published-print":{"date-parts":[[2000,4]]},"abstract":"<jats:p>A escolha da terapia mais apropriada para o paciente com bancroftose requer um conhecimento das diversas caracter\u00edsticas cl\u00ednicas da doen\u00e7a filarial e de sua patog\u00eanese. Como resultado de novos testes diagn\u00f3sticos e avan\u00e7os cl\u00ednicos, n\u00e3o apenas nosso entendimento sobre a filariose bancroftiana mudou rapidamente de forma, como as nossas id\u00e9ias sobre o tratamento. No passado, acreditava-se que a elefant\u00edase era causada pela rea\u00e7\u00e3o imunol\u00f3gica do hospedeiro ao parasita filarial. Posta dessa maneira, essa forma da doen\u00e7a seria o ponto final de uma inter-rela\u00e7\u00e3o h\u00f3spede-hospedeiro imut\u00e1vel, dada a inexist\u00eancia de medicamentos ou de condutas que possibilitassem a sua involu\u00e7\u00e3o nos denominados \"indiv\u00edduos imunologicamente predispostos\". Entretanto, nos \u00faltimos anos, surgiram evid\u00eancias de que o linfedema e a elefant\u00edase tinham outro agente etiol\u00f3gico. O principal fator de evolu\u00e7\u00e3o para os quadros de linfedema e elefanti\u00e1sicos seria o desenvolvimento de infec\u00e7\u00f5es bacterianas secund\u00e1rias de repeti\u00e7\u00e3o. Hoje, \u00e9 perfeitamente claro que outras formas de terapia de suporte (incluindo a educa\u00e7\u00e3o e o aconselhamento psicol\u00f3gico) s\u00e3o necess\u00e1rias e s\u00e3o, muitas vezes, mais importantes que a terapia antiparasit\u00e1ria.<\/jats:p>","DOI":"10.1590\/s0037-86822000000200010","type":"journal-article","created":{"date-parts":[[2005,4,26]],"date-time":"2005-04-26T16:46:51Z","timestamp":1114534011000},"page":"217-221","source":"Crossref","is-referenced-by-count":3,"title":["Bases para o tratamento da morbidade em \u00e1reas end\u00eamicas de filariose bancroftiana"],"prefix":"10.1590","volume":"33","author":[{"given":"Gerusa","family":"Dreyer","sequence":"first","affiliation":[{"name":"Universidade Federal de Pernambuco; FIOCRUZ"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patr\u00edcia","family":"Dreyer","sequence":"additional","affiliation":[{"name":"Universidade Federal de 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