{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:37:23Z","timestamp":1759541843582},"reference-count":14,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Soc. Bras. Med. Trop."],"published-print":{"date-parts":[[2000,8]]},"abstract":"<jats:p>Foi avaliada a toxicidade de dois antimoniais pentavalentes em 111 pacientes com leishmaniose cut\u00e2nea. Quarenta e sete pacientes receberam antimoniato de meglumina (Grupo I) e 64 pacientes, estibogluconato de s\u00f3dio BP 88\u00ae (Grupo II), 20mg SbV\/kg\/dia por 20 dias. Realizou-se a avalia\u00e7\u00e3o de aminotransferases, fosfatase alcalina, amilase, creatinina, ur\u00e9ia, exame de urina e eletrocardiograma, antes do tratamento e no d\u00e9cimo e vig\u00e9simo dias. Observou-se maior freq\u00fc\u00eancia de valores anormais de aminotransferases no d\u00e9cimo e vig\u00e9simo dias de tratamento no grupo II (p &lt; 0,001) e maior propor\u00e7\u00e3o de valores anormais de amilase no d\u00e9cimo dia no mesmo grupo (p &lt; 0,001). Houve maior varia\u00e7\u00e3o dos n\u00edveis de aminotransferases, fosfatase alcalina e amilase nos primeiros dez dias no grupo II (p &lt; 0,01). No vig\u00e9simo dia observou-se maior varia\u00e7\u00e3o nos n\u00edveis de aminotransferases no grupo II (p = 0,02 e p = 0,03, respectivamente). Quarenta e tr\u00eas porcento dos pacientes do grupo I e 54% dos pacientes do grupo II apresentaram altera\u00e7\u00f5es eletrocardiogr\u00e1ficas (p = 0,30).<\/jats:p>","DOI":"10.1590\/s0037-86822000000400009","type":"journal-article","created":{"date-parts":[[2005,4,26]],"date-time":"2005-04-26T12:47:31Z","timestamp":1114519651000},"page":"383-388","source":"Crossref","is-referenced-by-count":25,"title":["Estudo comparativo entre estibogluconato de s\u00f3dio BP 88\u00ae e antimoniato de meglumina no tratamento da leishmaniose cut\u00e2nea II. Toxicidade bioqu\u00edmica e card\u00edaca"],"prefix":"10.1590","volume":"33","author":[{"given":"Ana Cristina R.","family":"Saldanha","sequence":"first","affiliation":[{"name":"Universidade de Bras\u00edlia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo Adolfo Sierra","family":"Romero","sequence":"additional","affiliation":[{"name":"Universidade de Bras\u00edlia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Concei\u00e7\u00e3o","family":"Guerra","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Central de Sa\u00fade P\u00fablica, Prof. Gon\u00e7alo Moniz"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edgar","family":"Merchan-Hamann","sequence":"additional","affiliation":[{"name":"Universidade de Bras\u00edlia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanize de Oliveira","family":"Macedo","sequence":"additional","affiliation":[{"name":"Universidade de Bras\u00edlia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1093\/clinids\/10.3.560","article-title":"Chemotherapy for leishmaniasis: Biochemical mechanisms, clinical efficacy and future strategies","volume":"10","author":"Berman JD","year":"1988","journal-title":"Reviews of Infectious Diseases","ISSN":"http:\/\/id.crossref.org\/issn\/0162-0886","issn-type":"print"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"702","DOI":"10.4269\/ajtmh.1985.34.702","article-title":"Eletrocardiographic changes during treatment of leishmaniasis with pentavalent antimony (sodium stibogluconate)","volume":"34","author":"Chulay JD","year":"1985","journal-title":"The American Journal of Tropical Medicine and Hygiene"},{"key":"ref3","series-title":"Epidemiologia da Doen\u00e7a de Chagas: Objetivos e Metodologias de estudos longitudinais. 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