{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T15:42:06Z","timestamp":1770478926417,"version":"3.49.0"},"reference-count":15,"publisher":"FapUNIFESP (SciELO)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Soc. Bras. Med. Trop."],"published-print":{"date-parts":[[2000,12]]},"abstract":"<jats:p>Foi realizado ensaio cl\u00ednico randomizado simples cego para comparar a efic\u00e1cia e a toxicidade do estibogluconato de Na+ (ES) e o antimoniato de N-metil glucamina, o Glucantime\u00ae(GL). Sessenta e tr\u00eas pacientes foram distribu\u00eddos em um dos dois grupos: 32 pacientes foram tratados com GL e 31 pacientes com o ES. Ambos os grupos receberam 15mg Sb+5\/kg\/dia durante 20 dias. A toxicidade foi avaliada atrav\u00e9s do ECG, dosagens de ur\u00e9ia, creatinina, TGO, TGP, fosfatase alcalina, amilase, e lipase, avaliados antes do tratamento, nos dias 10 e 20 do tratamento, e 90 dias ap\u00f3s o t\u00e9rmino do mesmo. No grupo tratado com GL 81% (26\/32) dos pacientes curaram, comparados com 77% (24\/31) no grupo do ES. Um paciente em cada grupo n\u00e3o respondeu ao tratamento. TGO, TGP, amilase, e lipase foram mais elevadas no grupo que usou o ES (p &lt; 0,05). Concluiu-se que, a efic\u00e1cia de ambos os tratamentos foram similares, apesar da maior toxicidade observada no grupo tratado com ES.<\/jats:p>","DOI":"10.1590\/s0037-86822000000600004","type":"journal-article","created":{"date-parts":[[2005,4,26]],"date-time":"2005-04-26T16:47:49Z","timestamp":1114534069000},"page":"535-543","source":"Crossref","is-referenced-by-count":29,"title":["Avalia\u00e7\u00e3o comparativa da efic\u00e1cia e toxicidade do antimoniato de N-metil-glucamina e do Estibogluconato de S\u00f3dio BP88\u00ae no tratamento da leishmaniose cut\u00e2nea localizada"],"prefix":"10.1590","volume":"33","author":[{"given":"Patr\u00edcia D.","family":"Deps","sequence":"first","affiliation":[{"name":"Santa Casa de Miseric\u00f3rdia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Carmen","family":"Viana","sequence":"additional","affiliation":[{"name":"Santa Casa de Miseric\u00f3rdia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alo\u00edsio","family":"Falqueto","sequence":"additional","affiliation":[{"name":"Universidade Federal do Esp\u00edrito Santo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reynaldo","family":"Dietze","sequence":"additional","affiliation":[{"name":"Universidade Federal do Esp\u00edrito Santo"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1093\/clind\/24.4.684","article-title":"Human leishmaniasis: clinical, diagnostic, and chemotherapeutic developments in the last 10 years","volume":"24","author":"Berman JD","year":"1997","journal-title":"Clinical Infectious Diseases","ISSN":"https:\/\/id.crossref.org\/issn\/1058-4838","issn-type":"print"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/0035-9203(90)90318-9","article-title":"Severe arthralgia, not 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