{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:18:50Z","timestamp":1787023130355,"version":"build-2736575974"},"reference-count":34,"publisher":"FapUNIFESP (SciELO)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Soc. Bras. Med. Trop."],"published-print":{"date-parts":[[2002,10]]},"abstract":"<jats:p>A infec\u00e7\u00e3o pelos v\u00edrus HTLV-I\/II encontra-se presente em todas as regi\u00f5es brasileiras, mas as preval\u00eancias variam de um estado para outro, sendo mais elevadas na Bahia, Pernambuco e Par\u00e1. As estimativas indicam que o Brasil possui o maior n\u00famero absoluto de indiv\u00edduos infectados no mundo. Testes de triagem de doadores e estudos conduzidos em grupos especiais (popula\u00e7\u00f5es ind\u00edgenas, usu\u00e1rios de drogas intravenosas e gestantes) constituem as principais fontes de informa\u00e7\u00e3o sobre essas viroses em nosso pa\u00eds. O HTLV-I causa a leucemia\/linfoma de c\u00e9lulas T do adulto (LLTA), a paraparesia esp\u00e1stica tropical\/mielopatia associada ao HTLV (TSP\/HAM), uve\u00edte associada ao HTLV (HAU) e anormalidades dermatol\u00f3gicas e imunol\u00f3gicas. O HTLV-II n\u00e3o se mostrou associado a nenhuma doen\u00e7a at\u00e9 o momento. O diagn\u00f3stico \u00e9 feito com testes de triagem (ELISA, aglutina\u00e7\u00e3o) e confirmat\u00f3rios (Western Blot, PCR). Estes v\u00edrus s\u00e3o transmitidos pelo sangue e agulhas contaminadas, atrav\u00e9s de rela\u00e7\u00f5es sexuais e de m\u00e3e para filho, especialmente atrav\u00e9s do aleitamento materno. Medidas de preven\u00e7\u00e3o devem focalizar a orienta\u00e7\u00e3o de doadores soropositivos, m\u00e3es infectadas e usu\u00e1rios de drogas intravenosas.<\/jats:p>","DOI":"10.1590\/s0037-86822002000500013","type":"journal-article","created":{"date-parts":[[2005,4,26]],"date-time":"2005-04-26T12:49:37Z","timestamp":1114519777000},"page":"499-508","source":"Crossref","is-referenced-by-count":76,"title":["Infec\u00e7\u00e3o e doen\u00e7a pelos v\u00edrus linfotr\u00f3picos humanos de c\u00e9lulas T (HTLV-I\/II) no Brasil"],"prefix":"10.1590","volume":"35","author":[{"given":"Anna B\u00e1rbara F.","family":"Carneiro-Proietti","sequence":"first","affiliation":[{"name":"Funda\u00e7\u00e3o Hemominas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Gabriel Ramos","family":"Ribas","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Sarah Kubtischek"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernadette C.","family":"Catalan-Soares","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Hemominas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina L.","family":"Martins","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Hemominas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo E. 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Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0268-960X(97)90015-1","article-title":"Human T-cell leukemia viruses: epidemiology, biology and pathogenesis","volume":"11","author":"Ferreira Jr OC","year":"1997","journal-title":"Blood Reviews","ISSN":"https:\/\/id.crossref.org\/issn\/0268-960X","issn-type":"print"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"3619","DOI":"10.1182\/blood.V86.10.3619.bloodjournal86103619","article-title":"Molecular mechanisms of human T-Cell leukemia\/lymphotropic virus type I infection","volume":"86","author":"Franchini G","year":"1995","journal-title":"Blood","ISSN":"https:\/\/id.crossref.org\/issn\/0006-4971","issn-type":"print"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"664","DOI":"10.4269\/ajtmh.1993.49.664","article-title":"Selectivity of human T-lymphotropic virus type-1 (HTLV-1) and HTLV-2 infection among different populations in Brazil","volume":"49","author":"Gabbai AA","year":"1993","journal-title":"American Journal of Tropical Medical Hygiene"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1258\/0956462991914078","article-title":"Simultaneous occurrence of HTLV-I associated myelopathy, uveitis and smouldering adult T-cell leukaemia","volume":"10","author":"Gon\u00e7alves DU","year":"1999","journal-title":"International Journal of STD & AIDS"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0891-5520(05)70225-7","article-title":"Human T-cell lymphotropic virus-i in Latin America","volume":"14","author":"Gotuzzo E","year":"2000","journal-title":"Infectious Diseases Clinic North America"},{"key":"ref10","first-page":"597","article-title":"Infection \u00e0 HTLV-1 et syndrome sec","volume":"18","author":"Hajjar C","year":"1995","journal-title":"Journal Fran\u00e7ais Ophtalmologie"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0923-1811(92)90062-G","article-title":"Differences In HTLV-I Integration patterns between skin lesions and peripheral blood lymphocytes of HTLV-I seropositive patients with cutaneous lymphoproliferative disorders","volume":"4","author":"Hamada T","year":"1992","journal-title":"Journal Dermatological Science"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S1074-7613(00)00065-0","article-title":"Fratricide among CD8(+) T lymphocytes naturally infected with human T cell lymphotropic virus type I","volume":"13","author":"Hanon E","year":"2000","journal-title":"Immunity","ISSN":"https:\/\/id.crossref.org\/issn\/1074-7613","issn-type":"print"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0165-5728(89)90143-4","article-title":"Activated T lymphocytes in cerebrospinal fluid of patients with HTLV-I-associated myelopathy 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Sanguinis","ISSN":"https:\/\/id.crossref.org\/issn\/0042-9007","issn-type":"print"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1172\/JCI117735","article-title":"Immunopathological mechanisms of human t cell lymphotropic virus type 1 (HTLV) uveitis","volume":"95","author":"Sagawa K","year":"1995","journal-title":"Journal Clinical Investigation"},{"key":"ref30","first-page":"428","article-title":"Diagnostic criteria and classification of clinical sub-types of adult T-cell leukemia lymphoma","volume":"79","author":"Shimoyama M","year":"1991","journal-title":"A report from the Lymphoma Study Group (1984-78). British Journal Of Haematology"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1086\/514992","article-title":"Human patogenic virus-associated pseudolymphomas and lymphomas with primary cutaneous manifestations in humans and animals","volume":"27","author":"Wagner M","year":"1998","journal-title":"Clinical Infectious Diseases","ISSN":"https:\/\/id.crossref.org\/issn\/1058-4838","issn-type":"print"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1182\/blood.V82.6.1701.1701","article-title":"The interleukin-2 receptor: a target for monoclonal antibody treatment of human T cell lymphotropic virus 1 induced adult T cell leukemia lymphoma","volume":"82","author":"Waldmann TA","year":"1993","journal-title":"Blood","ISSN":"https:\/\/id.crossref.org\/issn\/0006-4971","issn-type":"print"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1001\/archopht.117.4.513","article-title":"Human T cell lymphotropic virus type 1 infection and ocular manifestations in S\u00e3o Paulo, Brazil","volume":"117","author":"Yamamoto JH","year":"1999","journal-title":"Archives Ophthalmology"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1073\/pnas.81.8.2534","article-title":"Monoclonal integration of human t-cell leukemia provirus in all primary tumours of adult T-cell leukemia suggests causative role of human T-cell leukemia virus in the disease","volume":"81","author":"Yoshida M","year":"1984","journal-title":"Proceedings of National Academy of Sciences USA,"}],"container-title":["Revista da Sociedade Brasileira de Medicina Tropical"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/rsbmt\/v35n5\/13170.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T22:40:06Z","timestamp":1586212806000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0037-86822002000500013&lng=pt&tlng=pt"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,10]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2002,10]]}},"alternative-id":["S0037-86822002000500013"],"URL":"https:\/\/doi.org\/10.1590\/s0037-86822002000500013","relation":{},"ISSN":["0037-8682"],"issn-type":[{"value":"0037-8682","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,10]]}}}