{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:02:54Z","timestamp":1777478574949,"version":"3.51.4"},"reference-count":26,"publisher":"FapUNIFESP (SciELO)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Soc. Bras. Med. Trop."],"published-print":{"date-parts":[[2002,12]]},"abstract":"<jats:p>Patients residing in endemic areas for schistosomiasis in Brazil are usually undernourished and when they develop the hepatosplenic clinical form of the disease should usually receive hospital care, many of them being in need of nutritional rehabilitation before specific treatment can be undertaken. In the mouse model, investigations carried out in our laboratory detected a reduced aminoacid uptake in undernourished animals which is aggravated by a superimposed infection with Schistosoma mansoni. However, in well-nourished infected mice no dysfunction occurs. In this study, we tried to improve the absorptive intestinal performance of undernourished mice infected with S. mansoni by feeding them with hydrolysed casein instead of whole casein. The values obtained for the coefficient of protein intestinal absorption (cpia) among well-nourished mice were above 90% (either hydrolysed or whole protein). In undernourished infected mice, however, the cpia improved significantly after feeding them with hydrolysed casein, animals reaching values close to those obtained in well-nourished infected mice.<\/jats:p>","DOI":"10.1590\/s0037-86822002000600007","type":"journal-article","created":{"date-parts":[[2005,4,26]],"date-time":"2005-04-26T16:49:43Z","timestamp":1114534183000},"page":"585-590","source":"Crossref","is-referenced-by-count":6,"title":["The use of protein hydrolysate improves the protein intestinal absorption in undernourished mice infected with Schistosoma mansoni"],"prefix":"10.1590","volume":"35","author":[{"given":"Eridan M.","family":"Coutinho","sequence":"first","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haroldo S.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Universidade Federal de Alagoas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica L.","family":"Assun\u00e7\u00e3o","sequence":"additional","affiliation":[{"name":"Universidade Federal de Alagoas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra L.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheilla A.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9a A.","family":"Francelino","sequence":"additional","affiliation":[{"name":"Universidade Federal de Alagoas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/0035-9203(64)90086-0","article-title":"Hepatic blood flow in mice with acute hepatic-splenic schistosomiasis mansoni","volume":"58","author":"Cheever AW","year":"1964","journal-title":"Transactions of the Royal Society of Tropical Medicine and Hygiene","ISSN":"https:\/\/id.crossref.org\/issn\/0035-9203","issn-type":"print"},{"key":"ref2","first-page":"185","article-title":"Fatores relacionados com o desenvolvimento das formas cl\u00ednicas da esquistossomose mans\u00f4nica","volume":"25","author":"Coutinho A","year":"1979","journal-title":"Revista da Associa\u00e7\u00e3o M\u00e9dica Brasileira","ISSN":"https:\/\/id.crossref.org\/issn\/0104-4230","issn-type":"print"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1590\/S0037-86821991000400006","article-title":"Liver and serum soluble protein changes and pathomorphology in undernourished mice with acute schistosomiasis mansoni","volume":"24","author":"Coutinho EM","year":"1991","journal-title":"Revista da Sociedade Brasileira de Medicina Tropical","ISSN":"https:\/\/id.crossref.org\/issn\/0037-8682","issn-type":"print"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1590\/S0074-02761992000800046","article-title":"Nutrition and acute schistosomiasis","volume":"87","author":"Coutinho EM","year":"1992","journal-title":"Mem\u00f3rias do Instituto Oswaldo Cruz","ISSN":"https:\/\/id.crossref.org\/issn\/0074-0276","issn-type":"print"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1590\/S0037-86821992000100003","article-title":"The influence of the Regional Basic Diet from Northeast Brazil on health and nutritional conditions of mice infected with Schistosoma mansoni","volume":"25","author":"Coutinho EM","year":"1992","journal-title":"Revista da Sociedade Brasileira de Medicina Tropical","ISSN":"https:\/\/id.crossref.org\/issn\/0037-8682","issn-type":"print"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"440","DOI":"10.4269\/ajtmh.1959.8.440","article-title":"Hepatosplenic schistosomiasis in mice","volume":"8","author":"DeWitt WB","year":"1959","journal-title":"American Journal of Tropical Medicine & Hygiene"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0016-5085(69)80122-8","article-title":"Pathophysiology of the small intestine in murine Schistosomiasis mansoni including a review of the literature","volume":"56","author":"Domingo EO","year":"1969","journal-title":"Gastroenterology","ISSN":"https:\/\/id.crossref.org\/issn\/0016-5085","issn-type":"print"},{"key":"ref8","first-page":"777","article-title":"Studies on the malabsorption syndrome among Egyptians: II - 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