{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T15:48:43Z","timestamp":1794671323381,"version":"4.9.1"},"reference-count":35,"publisher":"FapUNIFESP (SciELO)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Soc. Bras. Med. Trop."],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:p>INTRODUCTION: The purpose of this study was to evaluate risk factors for physical disability at the moment of leprosy diagnosis. METHODS: This is a retrospective, descriptive and exploratory investigation of 19,283 patients with leprosy, registered in the State of Minas Gerais, Brazil, between 2000 and 2005. RESULTS: The risk of Grade 2 disability was 16.5-fold higher in patients with lepromatous leprosy, and 12.8-fold higher in patients presenting the borderline form, compared to patients presenting indeterminate leprosy. The occurrence of more than one thickened nerve increased the odds of a patient developing Grade 2 disability, 8.4-fold. Age &lt;15 years, multibacillary leprosy and no formal education presented 7.0, 5.7 and 5.6 odds of developing physical disability, respectively. CONCLUSIONS: These factors should be considered as strong prognostic indicators in the development of physical disability at diagnosis.<\/jats:p>","DOI":"10.1590\/s0037-86822010000100005","type":"journal-article","created":{"date-parts":[[2010,3,17]],"date-time":"2010-03-17T12:51:47Z","timestamp":1268830307000},"page":"19-22","source":"Crossref","is-referenced-by-count":60,"title":["Risk factors for physical disability at diagnosis of 19,283 new cases of leprosy"],"prefix":"10.1590","volume":"43","author":[{"given":"Cristiane","family":"Moschioni","sequence":"first","affiliation":[{"name":"Federal University of Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Maur\u00edcio de Figueiredo","family":"Antunes","sequence":"additional","affiliation":[{"name":"Federal University of Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Aparecida Faria","family":"Grossi","sequence":"additional","affiliation":[{"name":"Secretary of Health of the Minas Gerais State, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Roberto","family":"Lambertucci","sequence":"additional","affiliation":[{"name":"Federal University of Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.47276\/lr.75.1.19","article-title":"Trends in leprosy case detection worldwide since 1985","volume":"75","author":"Meima A","year":"2004","journal-title":"Lepr Rev","ISSN":"https:\/\/id.crossref.org\/issn\/0305-7518","issn-type":"print"},{"key":"ref2","first-page":"118","article-title":"Global leprosy situation","volume":"80","year":"2004","journal-title":"Wkly Epidemiol Rec","ISSN":"https:\/\/id.crossref.org\/issn\/0049-8114","issn-type":"print"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"31","DOI":"10.47878\/hi.1997.v22.36453","article-title":"Estimado de preval\u00eancia de lepra","volume":"22","author":"Su\u00e1rez REG","year":"1997","journal-title":"Hansen Int"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.47878\/hi.1998.v23.36459","article-title":"A hansen\u00edase ap\u00f3s a cura","volume":"23","author":"Opromolla DVA","year":"1998","journal-title":"Hansen Int"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"155","DOI":"10.5935\/0305-7518.19800014","article-title":"Disability in leprosy: a relevant measurement of progress in leprosy control","volume":"51","author":"Smith WC","year":"1980","journal-title":"Lepr Rev","ISSN":"https:\/\/id.crossref.org\/issn\/0305-7518","issn-type":"print"},{"key":"ref6","first-page":"361","article-title":"Leprosy elimination campaigns","volume":"75","year":"2000","journal-title":"Wkly Epidemiol Rec","ISSN":"https:\/\/id.crossref.org\/issn\/0049-8114","issn-type":"print"},{"key":"ref7","series-title":"Leprosy","first-page":"134","volume-title":"Clinical leprosy","author":"Pfaltzgraff RE","year":"1985"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"5883","DOI":"10.4049\/jimmunol.166.10.5883","article-title":"Mycobacterium leprae-specific, HLA class II-restricted killing of human Schwann cells by CD4+ Th1 cells: a novel immunopathogenic mechanism of nerve damage in leprosy","volume":"166","author":"Spierings E","year":"2001","journal-title":"J Immunol","ISSN":"https:\/\/id.crossref.org\/issn\/0022-1767","issn-type":"print"},{"key":"ref9","first-page":"S19","article-title":"Pathology and pathogenesis of leprous neuritis; 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