{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T19:26:35Z","timestamp":1757705195723},"reference-count":50,"publisher":"FapUNIFESP (SciELO)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Soc. Bras. Med. Trop."],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:p>INTRODU\u00c7\u00c3O: A leishmaniose visceral \u00e9 uma doen\u00e7a infecciosa sist\u00eamica de ampla distribui\u00e7\u00e3o geogr\u00e1fica, caracterizada pelo alto potencial de letalidade. Visando contribuir com a redu\u00e7\u00e3o da mortalidade, bem como auxiliar profissionais da sa\u00fade no manejo cl\u00ednico dos pacientes portadores desse agravo, este trabalho teve como objetivo investigar as caracter\u00edsticas cl\u00ednicas e laboratoriais dos casos que evolu\u00edram para o \u00eaxito letal em hospitais de Campo Grande, MS, nos anos de 2003 a 2008. M\u00c9TODOS: Foram analisados 55 prontu\u00e1rios de pacientes que tiveram a leishmaniose visceral como causa de \u00f3bito. RESULTADOS: Dos 55 pacientes estudados, 37 eram procedentes do munic\u00edpio de Campo Grande, sendo 41 (74,5%) do sexo masculino, com predomin\u00e2ncia da faixa et\u00e1ria acima dos 40 anos. Quanto ao quadro cl\u00ednico, a febre esteve presente em 89,1% dos casos. A dura\u00e7\u00e3o da doen\u00e7a desde o in\u00edcio dos sintomas at\u00e9 a hospitaliza\u00e7\u00e3o variou em m\u00e9dia 78,2 dias. A leucopenia ocorreu em 85,5% dos pacientes. Comorbidades estiveram presentes em 39 (70,9%) pacientes, sendo a desnutri\u00e7\u00e3o e o etilismo as mais frequentes. A confirma\u00e7\u00e3o do diagn\u00f3stico ocorreu em m\u00e9dia 6,7 dias ap\u00f3s a interna\u00e7\u00e3o. O antimoniato pentavalente foi a droga mais utilizada, com 87,5% dos pacientes apresentando algum tipo de rea\u00e7\u00e3o adversa. Infec\u00e7\u00f5es bacterianas ocorreram em 36 pacientes e, em 27 (49%), foram uma das causas do \u00f3bito. CONCLUS\u00d5ES: Os dados indicam que a identifica\u00e7\u00e3o precoce dessas caracter\u00edsticas cl\u00ednicas e laboratoriais no primeiro atendimento ao paciente \u00e9 de fundamental import\u00e2ncia para se reduzir a mortalidade por meio da institui\u00e7\u00e3o de medidas terap\u00eauticas e profil\u00e1ticas eficazes.<\/jats:p>","DOI":"10.1590\/s0037-86822010000200016","type":"journal-article","created":{"date-parts":[[2010,4,29]],"date-time":"2010-04-29T09:39:58Z","timestamp":1272533998000},"page":"188-193","source":"Crossref","is-referenced-by-count":43,"title":["Mortalidade por leishmaniose visceral: aspectos cl\u00ednicos e laboratoriais"],"prefix":"10.1590","volume":"43","author":[{"given":"Janaina Michelle de","family":"Oliveira","sequence":"first","affiliation":[{"name":"Universidade Federal de Mato Grosso do Sul"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Claudia","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Universidade 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