{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:25:37Z","timestamp":1790691937335,"version":"4.1.0"},"reference-count":67,"publisher":"FapUNIFESP (SciELO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Soc. Bras. Med. Trop."],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:p>INTRODU\u00c7\u00c3O: A hist\u00f3ria das hepatites virais remonta milhares de anos e \u00e9 fascinante. Quando o ser humano sofreu pela primeira vez a invas\u00e3o do seu organismo por tais agentes, iniciou-se um ciclo natural e repetitivo capaz de infectar bilh\u00f5es de seres humanos, dizimar e sequelar milhares de vida. M\u00c9TODOS: Este artigo rever informa\u00e7\u00f5es cient\u00edficas dispon\u00edveis sobre o hist\u00f3rico das hepatites virais. Todas as informa\u00e7\u00f5es foram obtidas atrav\u00e9s de extensa revis\u00e3o bibliogr\u00e1fica, compreendendo artigos originais e de revis\u00e3o e consultas na rede internet. RESULTADOS: Existem relatos de surtos de icter\u00edcia epid\u00eamica na China h\u00e1 mais de 5.000 anos e na Babil\u00f4nia, h\u00e1 mais de 2.500 anos. A hist\u00f3ria catastr\u00f3fica das grandes epidemias ou pandemias ict\u00e9ricas s\u00e3o conhecidas e geralmente est\u00e3o associadas \u00e0s grandes guerras. Na guerra da Secess\u00e3o Americana, 40 mil casos ocorreram entre militares da Uni\u00e3o. Em 1885, um surto de icter\u00edcia catarral acometeu 191 trabalhadores do estaleiro de Bremen (Alemanha) ap\u00f3s vacina\u00e7\u00e3o contra var\u00edola. Em 1942, 28.585 soldados contra\u00edram hepatite ap\u00f3s inocula\u00e7\u00e3o da vacina contra a febre amarela. O n\u00famero de casos de hepatite durante a Segunda Grande Guerra foi estimado em 16 milh\u00f5es. Somente no s\u00e9culo XX, foram identificados os principais agentes causadores das hepatites virais. O v\u00edrus da hepatite B foi o primeiro a ser descoberto. CONCLUS\u00d5ES: Neste artigo, a revis\u00e3o da hist\u00f3ria das grandes epidemias ocasionadas pelos v\u00edrus das hepatites e a descoberta desses agentes revelam singulares peculiaridades, citando como exemplo, a descoberta acidental ou por acaso dos v\u00edrus da hepatite B e D.<\/jats:p>","DOI":"10.1590\/s0037-86822010000300022","type":"journal-article","created":{"date-parts":[[2010,6,16]],"date-time":"2010-06-16T21:06:57Z","timestamp":1276722417000},"page":"322-330","source":"Crossref","is-referenced-by-count":24,"title":["Hist\u00f3rico das hepatites virais"],"prefix":"10.1590","volume":"43","author":[{"given":"Jos\u00e9 Carlos Ferraz da","family":"Fonseca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","series-title":"Hepatites V\u00edricas: Perspectiva hist\u00f3rica","author":"Freitas J"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1002\/hep.510360341","article-title":"Landmarks in hepatology: the thin red line","volume":"36","author":"Reuben A","year":"2002","journal-title":"Hepatol"},{"key":"ref3","series-title":"The five viruses: a perspective","first-page":"p 2","author":"Hollinger FB","year":"1994"},{"issue":"2","key":"ref4","volume":"1751","author":"La Condaimine MM","year":"2009","journal-title":"Journal du voyage fait par ordre du roi, a l'Equateur, servant d'introduction historique a la Mesure des trois premiers degres du meridien"},{"key":"ref5","first-page":"149","article-title":"The unexpected outcomes of medical research: serendipity and the Australia antigen","volume":"39","author":"Alter HJ","year":"2003","journal-title":"J Hepatol","ISSN":"https:\/\/id.crossref.org\/issn\/0168-8278","issn-type":"print"},{"key":"ref6","series-title":"Viral Hepatitis and Liver Disease","first-page":"1","volume-title":"Viral hepatitis: Some Historical Perspectives","author":"Schimid R","year":"1994"},{"key":"ref7","series-title":"Hist\u00f3ria da Febre Amarela no Brasil","author":"Franco O","year":"1969"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1056\/NEJM198704163161601","article-title":"A serologic follow-up of the 1942 epidemic of post-vaccination hepatitis in the United States Army","volume":"316","author":"Seeff LB","year":"1987","journal-title":"New England J Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1001\/jama.1965.03080070025007","article-title":"A \"new\" antingen in leukemia sera","volume":"191","author":"Blumberg BS","year":"1965","journal-title":"JAMA","ISSN":"https:\/\/id.crossref.org\/issn\/0098-7484","issn-type":"print"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"924","DOI":"10.7326\/0003-4819-66-5-924","article-title":"A serum antigen (Australia antigen) in Down's syndrome, leukemia and hepatitis","volume":"66","author":"Blumberg BS","year":"1967","journal-title":"Ann Int Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1001\/jama.1967.03120180053006","article-title":"Infectious hepatitis: evidence for two distinctive clinical, epidemiological, and immunological types of infection","volume":"200","author":"Krugman S","year":"1967","journal-title":"JAMA","ISSN":"https:\/\/id.crossref.org\/issn\/0098-7484","issn-type":"print"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1126\/science.182.4116.1026","article-title":"Hepatitis A: detection by immune electron microscopy of virus like antigen associated with acute illness","volume":"182","author":"Feinstone SM","year":"1973","journal-title":"Science","ISSN":"https:\/\/id.crossref.org\/issn\/0036-8075","issn-type":"print"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1093\/infdis\/131.2.167","article-title":"Hepatitis A: report of a common-source outbreak with recovery of a possible etiologic agent. 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