{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T15:29:55Z","timestamp":1772465395443,"version":"3.50.1"},"reference-count":37,"publisher":"FapUNIFESP (SciELO)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Soc. Bras. Med. Trop."],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:p>INTRODUCTION: The current prevalence of glomerulonephritis in patients with hepatosplenic schistosomiasis mansoni in Brazil was evaluated. METHODS: Sixty three patients (mean age 45.5\u00b111 years) attending the outpatient infectious disease clinic of a University Hospital in Belo Horizonte, Brazil, from 2007 to 2009, were consecutively examined and enrolled in the present investigation. Diagnosis of hepatosplenic schistosomiasis was based on epidemiological, clinical and parasitological data and imaging techniques. Eight patients, who presented &gt;30mg\/day albuminuria, were submitted to percutaneous ultrasound guided renal biopsy. Kidney tissue fragments were examined under light, direct immunofluorescence and electron microscopy. RESULTS: All patients showed mesangial enlargement. In five, mesangial hypercellularity was observed and four presented duplication of the glomerular basement membrane. Areas of glomerular sclerosis were diagnosed in four. Deposits of immunoglobulin M and C3 were present in six samples; deposits of IgG in four, IgA in three and C1q in two samples. In all patients, immunoglobulin A was reported in the lumen of renal tubules. Deposits of kappa and lambda were observed in six samples. Electron microscopy revealed dense deposits in the glomerular tissue of three patients. Arterial hypertension, small esophageal varices, slight increases in serum creatinine and decreases in serum albumin were associated with glomerular disease. CONCLUSIONS: Renal disease associated with hepatosplenic schistosomiasis was verified in 12.7% of patients and type I membranoproliferative glomerulonephritis was observed in 50% of them. Schistosomal glomerulopathy still is an important problem in patients with hepatosplenic schistosomiasis in Brazil.<\/jats:p>","DOI":"10.1590\/s0037-86822010000600007","type":"journal-article","created":{"date-parts":[[2010,12,20]],"date-time":"2010-12-20T06:28:49Z","timestamp":1292826529000},"page":"638-642","source":"Crossref","is-referenced-by-count":31,"title":["Glomerulonephritis in schistosomiasis mansoni: a time to reappraise"],"prefix":"10.1590","volume":"43","author":[{"given":"Val\u00e9rio Ladeira","family":"Rodrigues","sequence":"first","affiliation":[{"name":"Federal University of Minas Gerais,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alba","family":"Otoni","sequence":"additional","affiliation":[{"name":"Federal University of Minas Gerais,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izabela","family":"Voieta","sequence":"additional","affiliation":[{"name":"Federal University of Minas Gerais,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Maur\u00edcio de Figueiredo","family":"Antunes","sequence":"additional","affiliation":[{"name":"Federal University of Minas Gerais,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Roberto","family":"Lambertucci","sequence":"additional","affiliation":[{"name":"Federal University of Minas Gerais,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","year":"2009"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1590\/S0037-86821987000100010","article-title":"A esquistossomose mansoni em Minas Gerais","volume":"20","author":"Lambertucci JR","year":"1987","journal-title":"Rev Soc Bras Med Trop","ISSN":"https:\/\/id.crossref.org\/issn\/0037-8682","issn-type":"print"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"97","DOI":"10.4269\/ajtmh.1988.38.97","article-title":"Glomerulonephritis in Salmonella-Schistosoma mansoni association","volume":"38","author":"Lambertucci JR","year":"1988","journal-title":"Am J Trop Med Hyg","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9637","issn-type":"print"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1590\/S0037-86821987000200004","article-title":"Renal involvement in Salmonella-Schistosoma mansoni association","volume":"20","author":"Lambertucci JR","year":"1987","journal-title":"Rev Soc Bras Med Trop","ISSN":"https:\/\/id.crossref.org\/issn\/0037-8682","issn-type":"print"},{"key":"ref5","series-title":"Human Schistosomiasis","first-page":"195","volume-title":"Schistosoma mansoni: pathological and clinical aspects","author":"Lambertucci JR","year":"1993"},{"key":"ref6","first-page":"36","article-title":"Renal lesions in hepatosplenic schistosomiasis","volume":"10","author":"Andrade ZA","year":"1968","journal-title":"Rev Inst Med Trop Sao Paulo","ISSN":"https:\/\/id.crossref.org\/issn\/0036-4665","issn-type":"print"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1590\/S0037-86821985000100003","article-title":"A field study of proteinuria in individuals infected with Schistosoma mansoni","volume":"18","author":"Bina JC","year":"1985","journal-title":"Rev Soc Bras Med Trop","ISSN":"https:\/\/id.crossref.org\/issn\/0037-8682","issn-type":"print"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1590\/S0036-46651999000500001","article-title":"Schistosoma mansoni associated glomerulopathy","volume":"41","author":"Brito T","year":"1999","journal-title":"Rev Inst Med Trop S Paulo","ISSN":"https:\/\/id.crossref.org\/issn\/0036-4665","issn-type":"print"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"616","DOI":"10.4269\/ajtmh.1975.24.616","article-title":"The association of schistosomiasis mansoni and proteinuria in an endemic area: A preliminary report","volume":"24","author":"Lehman Jr JS","year":"1975","journal-title":"Am J Trop Med Hyg","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9637","issn-type":"print"},{"key":"ref10","first-page":"279","article-title":"Revis\u00e3o\/atualiza\u00e7\u00e3o em nefrologia cl\u00ednica: envolvimento glomerular na esquistossomose mans\u00f4nica","volume":"3","author":"Martinelli R","year":"1996","journal-title":"J Bras Nefrol","ISSN":"https:\/\/id.crossref.org\/issn\/0101-2800","issn-type":"print"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0035-9203(93)90485-9","article-title":"Evaluation of proteinuria in an area of Brazil endemic for schistosomiasis using a single urine sample","volume":"87","author":"Rabello AL","year":"1993","journal-title":"Trans R Soc Trop Med Hyg","ISSN":"https:\/\/id.crossref.org\/issn\/0035-9203","issn-type":"print"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"108","DOI":"10.4269\/ajtmh.1976.25.108","article-title":"Renal involvement in patients with hepatosplenic schistosomiasis mansoni","volume":"25","author":"Rocha H","year":"1976","journal-title":"Am J Trop Med Hyg","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9637","issn-type":"print"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/ki.1989.278","article-title":"A prospective, randomized therapeutic trial for schistosomal specific nephropathy","volume":"36","author":"Sobh MA","year":"1989","journal-title":"Kidney Int","ISSN":"https:\/\/id.crossref.org\/issn\/0085-2538","issn-type":"print"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"S131","DOI":"10.1046\/j.1523-1755.63.s83.28.x","article-title":"Nephrology in Latin America, with special emphasis on Brazil","volume":"83","author":"Zatz R","year":"2003","journal-title":"Kidney Int","ISSN":"https:\/\/id.crossref.org\/issn\/0085-2538","issn-type":"print"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ki.1993.205","article-title":"Schistosomal glomerulopathies","volume":"44","author":"Barsoum RS","year":"1993","journal-title":"Kidney Int","ISSN":"https:\/\/id.crossref.org\/issn\/0085-2538","issn-type":"print"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.1111\/j.1523-1755.2004.66042.x","article-title":"The changing face of schistosomal glomerulopathy","volume":"66","author":"Barsoum RS","year":"2004","journal-title":"Kidney Int","ISSN":"https:\/\/id.crossref.org\/issn\/0085-2538","issn-type":"print"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1590\/S0074-02761998000700062","article-title":"The situation of hepatosplenic schistosomiasis in Brazil today","volume":"93","author":"Andrade ZA","year":"1998","journal-title":"Mem Inst Oswaldo Cruz","ISSN":"https:\/\/id.crossref.org\/issn\/0074-0276","issn-type":"print"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"76","DOI":"10.4269\/ajtmh.1982.31.76","article-title":"The Brazilian program for schistosomiasis control, 1975-1979","volume":"31","author":"Machado PA","year":"1982","journal-title":"Am J Trop Med Hyg","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9637","issn-type":"print"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1590\/S0074-02762006000900012","article-title":"An analysis of the impact of the Schistosomiasis Control Programme in Brazil","volume":"101","author":"Amaral RS","year":"2006","journal-title":"Mem Inst Oswaldo Cruz","ISSN":"https:\/\/id.crossref.org\/issn\/0074-0276","issn-type":"print"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1590\/S0074-02762006000900007","article-title":"Morbidity of schistosomiasis mansoni in the state of Minas Gerais, Brazil","volume":"101","author":"Drummond SC","year":"2006","journal-title":"Mem Inst Oswaldo Cruz","ISSN":"https:\/\/id.crossref.org\/issn\/0074-0276","issn-type":"print"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1590\/S0074-02762001000900022","article-title":"Hepatosplenic schistosomiasis in field-based studies: a combined clinical and sonographic definition","volume":"96","author":"Lambertucci JR","year":"2001","journal-title":"Mem Inst Oswaldo Cruz","ISSN":"https:\/\/id.crossref.org\/issn\/0074-0276","issn-type":"print"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0001-706X(00)00124-8","article-title":"Schistosoma mansoni: assessment of morbidity before and after control","volume":"77","author":"Lambertucci JR","year":"2000","journal-title":"Acta Trop","ISSN":"https:\/\/id.crossref.org\/issn\/0001-706X","issn-type":"print"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.actatropica.2008.07.009","article-title":"Imaging techniques in the evaluation of morbidity in schistosomiasis mansoni","volume":"108","author":"Lambertucci JR","year":"2008","journal-title":"Acta Trop","ISSN":"https:\/\/id.crossref.org\/issn\/0001-706X","issn-type":"print"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1590\/S0036-46651994000400008","article-title":"Sonographic features of portal hypertension in schistosomiasis mansoni","volume":"36","author":"Pinto-Silva RA","year":"1994","journal-title":"Rev Inst Med Trop Sao Paulo","ISSN":"https:\/\/id.crossref.org\/issn\/0036-4665","issn-type":"print"},{"key":"ref25","year":"1998"},{"key":"ref26","series-title":"Glomerulopatias: patogenia, cl\u00ednica e tratamento","first-page":"25","volume-title":"Bi\u00f3psia renal","author":"Quintino-de-Lima E","year":"2006","edition":"2"},{"key":"ref27","series-title":"Applied Survival Analysis: Regression Modeling of Time to Event Data","author":"Hosmer DW","year":"1999"},{"key":"ref28","first-page":"769","article-title":"Factors affecting C3 in intestinal schistosomiasis","volume":"3","author":"Hussein MM","year":"1993","journal-title":"J Egypt Soc Parasitol","ISSN":"https:\/\/id.crossref.org\/issn\/0253-5890","issn-type":"print"},{"key":"ref29","first-page":"354","article-title":"Complement components and immunoglobulins in patients with schistosomiasis","volume":"34","author":"Madwar MA","year":"1978","journal-title":"Clin Exp Immunol","ISSN":"https:\/\/id.crossref.org\/issn\/0009-9104","issn-type":"print"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.4269\/ajtmh.1981.30.1020","article-title":"Correlation between circulating antigens detected by the radioimmunoprecipitation-polyethylene glycol assay (RIPEGA) and C1q-binding immune complexes in human schistosomiasis mansoni","volume":"30","author":"Santoro F","year":"1981","journal-title":"Am J Trop Med Hyg","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9637","issn-type":"print"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.pt.2004.05.007","article-title":"Intravascular schistosomes and complement","volume":"20","author":"Skelly PJ","year":"2004","journal-title":"Trends Parasitol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"61","DOI":"10.4269\/ajtmh.1983.32.61","article-title":"Circulating immune complexes and rheumatoid factor in schistosomiasis and visceral leishmaniasis","volume":"32","author":"Carvalho EM","year":"1983","journal-title":"Am J Trop Med Hyg","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9637","issn-type":"print"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3109\/03009748809096783","article-title":"Rheumatoid factors in leprosy and parasitic diseases","volume":"75","author":"Harboe M","year":"1988","journal-title":"Scand J Rheumatol","ISSN":"https:\/\/id.crossref.org\/issn\/0300-9742","issn-type":"print"},{"key":"ref34","first-page":"289","article-title":"A study of autoimmunity in schistosomiasis","volume":"23","author":"Abbas MM","year":"1993","journal-title":"J Egypt Soc Parasitol","ISSN":"https:\/\/id.crossref.org\/issn\/0253-5890","issn-type":"print"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"196","DOI":"10.4269\/ajtmh.1988.39.196","article-title":"Morbidity associated with Schistosoma mansoni infection as determined by ultrasound: a study in Gezira, Sudan","volume":"39","author":"Homeida M","year":"1988","journal-title":"Am J Trop Med Hyg","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9637","issn-type":"print"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"43","DOI":"10.5387\/fms.54.43","article-title":"The pathogenesis and treatment of IgA nephropathy","volume":"54","author":"Kawasaki Y","year":"2008","journal-title":"Fukushima J Med Sci","ISSN":"https:\/\/id.crossref.org\/issn\/0016-2590","issn-type":"print"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.mcna.2009.03.003","article-title":"Renal failure in patients with cirrhosis","volume":"93","author":"Mackelaite L","year":"2009","journal-title":"Med Clin North Am","ISSN":"https:\/\/id.crossref.org\/issn\/0025-7125","issn-type":"print"}],"container-title":["Revista da Sociedade Brasileira de Medicina Tropical"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/rsbmt\/v43n6\/07.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,5,26]],"date-time":"2017-05-26T18:08:15Z","timestamp":1495822095000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0037-86822010000600007&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["S0037-86822010000600007"],"URL":"https:\/\/doi.org\/10.1590\/s0037-86822010000600007","relation":{},"ISSN":["0037-8682"],"issn-type":[{"value":"0037-8682","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12]]}}}