{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:27:51Z","timestamp":1761128871325},"reference-count":36,"publisher":"FapUNIFESP (SciELO)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Soc. Bras. Med. Trop."],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:p>INTRODU\u00c7\u00c3O: A mielopatia associada ao retrov\u00edrus HTLV-1 (HAM\/TSP) \u00e9 uma doen\u00e7a progressiva e incapacitante. O objetivo deste trabalho \u00e9 determinar caracter\u00edsticas cl\u00ednico-epidemiol\u00f3gicas de pacientes com HAM\/TSP. M\u00c9TODOS: S\u00e9rie de casos admitidos de 01\/1998 a 12\/ 2007, em hospital de reabilita\u00e7\u00e3o utilizando os crit\u00e9rios diagn\u00f3sticos de HAM\/TSP. RESULTADOS: Participaram 206 pacientes, dos quais, 67% eram mulheres, com 53 anos de m\u00e9dia de idade, nove anos de m\u00e9dia de dura\u00e7\u00e3o de doen\u00e7a. Os sintomas mais frequentes foram a diminui\u00e7\u00e3o da for\u00e7a em membros inferiores, espasticidade, dor, presen\u00e7a de bexiga neurog\u00eanica e a constipa\u00e7\u00e3o intestinal. Os sinais neurol\u00f3gicos foram hiperreflexia, Babinsky, Hoffmann e neuropatia perif\u00e9rica. A presen\u00e7a de dor, de espasticidade muscular e de atrofia medular \u00e0 resson\u00e2ncia nuclear magn\u00e9tica de medula espinhal foram associadas \u00e0 dura\u00e7\u00e3o da doen\u00e7a (p&lt;0,05). CONCLUS\u00d5ES: A HAM\/TSP \u00e9 uma doen\u00e7a de curso incapacitante e progressiva, em que a dor \u00e9 relatada precocemente, enquanto a atrofia medular tor\u00e1cica e a espasticidade surgem em fase mais tardia. Existem casos de HAM\/TSP com prov\u00e1vel transmiss\u00e3o do v\u00edrus por via vertical.<\/jats:p>","DOI":"10.1590\/s0037-86822010000600013","type":"journal-article","created":{"date-parts":[[2010,12,20]],"date-time":"2010-12-20T06:28:56Z","timestamp":1292826536000},"page":"668-672","source":"Crossref","is-referenced-by-count":14,"title":["Mielopatia associada ao HTLV-1: an\u00e1lise cl\u00ednico-epidemiol\u00f3gica em uma s\u00e9rie de casos de 10 anos"],"prefix":"10.1590","volume":"43","author":[{"given":"Ana Paula Silva","family":"Champs","sequence":"first","affiliation":[{"name":"Unidade Belo Horizonte; Universidade Federal de Minas Gerais"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9ria Maria de Azeredo","family":"Passos","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais; Universidade Federal de Minas Gerais"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandhi Maria","family":"Barreto","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais; Universidade Federal de Minas Gerais"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz Sergio","family":"Vaz","sequence":"additional","affiliation":[{"name":"Unidade Belo Horizonte"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Gabriel Ramos","family":"Ribas","sequence":"additional","affiliation":[{"name":"Unidade Belo Horizonte"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1182\/blood.V50.3.481.481","article-title":"Adult T-cell leukemia: clinical and hematologic features of 16 cases","volume":"50","author":"Uchiyama T","year":"1977","journal-title":"Blood","ISSN":"http:\/\/id.crossref.org\/issn\/0006-4971","issn-type":"print"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1126\/science.6981847","article-title":"A new subtype of human T-cell leukemia virus (HTLV-II) associated with a T-cell variant of hairy cell leukemia","volume":"218","author":"Kalyanaraman VS","year":"1982","journal-title":"Science","ISSN":"http:\/\/id.crossref.org\/issn\/0036-8075","issn-type":"print"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0022-510X(69)90067-7","article-title":"A spastic paraplegic syndrome in South India","volume":"9","author":"Mani KS","year":"1969","journal-title":"J Neurol Sci","ISSN":"http:\/\/id.crossref.org\/issn\/0022-510X","issn-type":"print"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/S0140-6736(86)91298-5","article-title":"HTLV-I associated myelopathy, a new clinical entity","volume":"1","author":"Osame M","year":"1986","journal-title":"Lancet","ISSN":"http:\/\/id.crossref.org\/issn\/0099-5355","issn-type":"print"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1016\/S0140-6736(85)90778-0","article-title":"HTLV-I and HTLV-III antibodies and tropical spastic paraparesis","volume":"2","author":"Rodgers-Johnson P","year":"1985","journal-title":"Lancet","ISSN":"http:\/\/id.crossref.org\/issn\/0099-5355","issn-type":"print"},{"key":"ref6","first-page":"501","article-title":"HTLV-I associated myelopathy in Brazil: a preliminary report","volume":"7","author":"Martins-Castro LH","year":"1989","journal-title":"Arq Neuropsiquiatr","ISSN":"http:\/\/id.crossref.org\/issn\/0004-282X","issn-type":"print"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"6058","DOI":"10.1038\/sj.onc.1208968","article-title":"Global epidemiology of HTLV-I infection and associated diseases","volume":"24","author":"Proietti FA","year":"2005","journal-title":"Oncogene","ISSN":"http:\/\/id.crossref.org\/issn\/0950-9232","issn-type":"print"},{"key":"ref8","first-page":"21","article-title":"Neuropathology of human and experimental TSP\/HAM: a critical review","volume":"102","author":"Costa CMC","year":"2002","journal-title":"Acta Neurol Belg","ISSN":"http:\/\/id.crossref.org\/issn\/0300-9009","issn-type":"print"},{"key":"ref9","first-page":"416","article-title":"Counseling blood donors seropositive for human T-Lymphotropic virus type I and II in a developing Country","volume":"14","author":"Passos VMA","year":"1998","journal-title":"Cad Saude Publica","ISSN":"http:\/\/id.crossref.org\/issn\/0102-311X","issn-type":"print"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1089\/aid.2006.22.931","article-title":"Proposal for diagnostic criteria of tropical spastic paraparesis\/HTLV-I-associated myelopathy (TSP\/HAM)","volume":"22","author":"Castro-Costa CM","year":"2006","journal-title":"AIDS Res Hum Retroviruses","ISSN":"http:\/\/id.crossref.org\/issn\/0889-2229","issn-type":"print"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1590\/S0037-86822002000400015","article-title":"Mielopatia associada ao v\u00edrus linfotr\u00f3pico humano de c\u00e9lulas T do tipo 1 (HTLV-1)","volume":"35","author":"Ribas JGR","year":"2002","journal-title":"Rev Soc Bras Med Trop","ISSN":"http:\/\/id.crossref.org\/issn\/0037-8682","issn-type":"print"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1590\/S0004-282X1992000200009","article-title":"Evidence of preferential female prevalence of HTLV-I associated tropical spastic paraparesis in Bahia-Brazil","volume":"50","author":"Moreno-Carvalho OA","year":"1992","journal-title":"Arq Neuropsiquiatr","ISSN":"http:\/\/id.crossref.org\/issn\/0004-282X","issn-type":"print"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1600-0404.1993.tb04188.x","article-title":"Clinical and demographic features of HTLV-1 associated myelopathy\/tropical spastic paraparesis (HAM\/TSP) in Rio de Janeiro, Brazil","volume":"88","author":"Araujo AQ","year":"1993","journal-title":"Acta Neurol Scand","ISSN":"http:\/\/id.crossref.org\/issn\/0001-6314","issn-type":"print"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1093\/clinids\/20.6.1540","article-title":"Human T lymphotropic virus type I-associated myelopathy\/tropical spastic paraparesis in Sao Paulo, Brazil","volume":"20","author":"Domingues RB","year":"1995","journal-title":"Clin Infect Dis","ISSN":"http:\/\/id.crossref.org\/issn\/1058-4838","issn-type":"print"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1097\/00042560-199812150-00014","article-title":"HTLV-I-associated myelopathy\/tropical spastic paraparesis in Brazil: a nationwide survey. HAM\/TSP Brazilian Study Group","volume":"19","author":"Araujo AQ","year":"1998","journal-title":"J Acquir Immune Defic Syndr Hum Retrovirol","ISSN":"http:\/\/id.crossref.org\/issn\/1077-9450","issn-type":"print"},{"key":"ref16","first-page":"126","article-title":"HTLV-I associated myelopathy: clinical and epidemiological profile","volume":"4","author":"Figueiroa FL","year":"2000","journal-title":"Braz J Infect Dis","ISSN":"http:\/\/id.crossref.org\/issn\/1413-8670","issn-type":"print"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1159\/000054813","article-title":"Human T cell lymphotropic virus type 1-associated myelopathy in Sao Paulo, Brazil: Epidemiologic and clinical features of a university hospital cohort","volume":"21","author":"Milagres AC","year":"2002","journal-title":"Neuroepidemiology","ISSN":"http:\/\/id.crossref.org\/issn\/0251-5350","issn-type":"print"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1590\/S0037-86822007000100007","article-title":"Perfil sociodemogr\u00e1fico, epidemiol\u00f3gico e comportamental de mulheres infectadas pelo HTLC-1 em Salvador-Bahia, uma \u00e1rea end\u00eamica para o HTLV","volume":"40","author":"Moxoto I","year":"2007","journal-title":"Rev Soc Bras Med Trop","ISSN":"http:\/\/id.crossref.org\/issn\/0037-8682","issn-type":"print"},{"key":"ref19","first-page":"24","article-title":"Diretrizes Brasileiras de Hipertens\u00e3o Arterial","volume":"89","year":"2007","journal-title":"Arq Bras Cardiol","ISSN":"http:\/\/id.crossref.org\/issn\/0066-782X","issn-type":"print"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1590\/S0004-27302002000100004","article-title":"Diabetes Melito: Diagn\u00f3stico, classifica\u00e7\u00e3o e avalia\u00e7\u00e3o do controle glic\u00eamico","volume":"46","author":"Gross JL","year":"2002","journal-title":"Arq Bras Endocrinol Metab"},{"key":"ref21","first-page":"331","author":"Larsen PR","year":"2003"},{"key":"ref22","series-title":"Manual diagn\u00f3stico e estat\u00edstico de transtornos mentais (DSM-4)","year":"1995"},{"key":"ref23","first-page":"527","article-title":"Bladder management for adults with spinal cord injury: A Clinical Practice Guideline for Health-Care Providers","volume":"29","year":"2006","journal-title":"J Spinal Cord Med","ISSN":"http:\/\/id.crossref.org\/issn\/1079-0268","issn-type":"print"},{"key":"ref24","series-title":"Neurogenic bowel management in adults with spinal cord injury: Clinical practice guidelines","first-page":"248","year":"1998"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/S0090-4295(97)00238-0","article-title":"The international index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction","volume":"49","author":"Rosen RC","year":"1997","journal-title":"Urology","ISSN":"http:\/\/id.crossref.org\/issn\/0090-4295","issn-type":"print"},{"key":"ref26","series-title":"International standards for neurological classification of spinal cord injury","year":"2002"},{"key":"ref27","series-title":"Diretrizes e normas regulamentadoras de pesquisas envolvendo seres humanos: Resolu\u00e7\u00e3o n\u00ba 196 do Conselho Nacional de Sa\u00fade","year":"1996"},{"key":"ref28","first-page":"116","article-title":"HTLV-1 associated myelopathy: a report of 85 cases","volume":"22","author":"Osame M","year":"1987","journal-title":"Ann Neurol","ISSN":"http:\/\/id.crossref.org\/issn\/0364-5134","issn-type":"print"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1750-3639.1993.tb00719.x","article-title":"Human T-cell leukemia virus type I Infection and chronic myelopathy","volume":"3","author":"Iwasaki Y","year":"1993","journal-title":"Brain Pathol","ISSN":"http:\/\/id.crossref.org\/issn\/1015-6305","issn-type":"print"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1038\/sj.ijir.3901335","article-title":"Erectile dysfunction and HTLV-I infection: a silent problem","volume":"17","author":"Castro N","year":"2005","journal-title":"Int J Impot Res","ISSN":"http:\/\/id.crossref.org\/issn\/0955-9930","issn-type":"print"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/j.0141-9838.2004.00726.x","article-title":"Epidemiological and clinical interaction between HTLV-1 and Strongyloides stercoralis","volume":"26","author":"Carvalho EM","year":"2004","journal-title":"Parasite Immunol","ISSN":"http:\/\/id.crossref.org\/issn\/0141-9838","issn-type":"print"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1590\/S0037-86822003000400021","article-title":"Gastric strongyloidiasis and infection by the human T cell lymphotropic virus type 1 (HTLV-1)","volume":"36","author":"Lambertucci JR","year":"2003","journal-title":"Rev Soc Bras Med Trop","ISSN":"http:\/\/id.crossref.org\/issn\/0037-8682","issn-type":"print"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1136\/jnnp.53.4.358-a","article-title":"Chronic polyradiculoneuropathy associated with human T-cell lymphotropic virus type I infection","volume":"53","author":"Arakawa K","year":"1990","journal-title":"J Neurol Neurosurg Psychiatry","ISSN":"http:\/\/id.crossref.org\/issn\/0022-3050","issn-type":"print"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/nen.0b013e31815f38b7","article-title":"Inclusion body myositis associated with human T-lymphotropic virus-type I infection: eleven patients from an endemic area in Japan","volume":"67","author":"Matsuura E","year":"2008","journal-title":"J Neuropathol Exp Neurol","ISSN":"http:\/\/id.crossref.org\/issn\/0022-3069","issn-type":"print"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1471-2334-7-15","article-title":"The cause of urinary symptoms among Human T Lymphotropic Virus Type I (HLTV-I) infected patients: a cross sectional study","volume":"7","author":"Rocha PN","year":"2007","journal-title":"BMC Infect Dis"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.5980\/jpnjurol1989.85.1106","article-title":"Studies on neurogenic bladder due to human T-lymphotropic virus type-I associated myelopathy (HAM)","volume":"85","author":"Imamura A","year":"1994","journal-title":"Nippon Hinyokika Gakkai Zasshi","ISSN":"http:\/\/id.crossref.org\/issn\/0021-5287","issn-type":"print"}],"container-title":["Revista da Sociedade Brasileira de Medicina Tropical"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/rsbmt\/v43n6\/13.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,14]],"date-time":"2020-06-14T21:18:11Z","timestamp":1592169491000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0037-86822010000600013&lng=pt&tlng=pt"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["S0037-86822010000600013"],"URL":"https:\/\/doi.org\/10.1590\/s0037-86822010000600013","relation":{},"ISSN":["0037-8682"],"issn-type":[{"value":"0037-8682","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12]]}}}