{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T15:59:41Z","timestamp":1649174381504},"reference-count":24,"publisher":"FapUNIFESP (SciELO)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Soc. Bras. Med. Trop."],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:p>INTRODU\u00c7\u00c3O: O impacto da terapia antirretroviral altamente ativa na progress\u00e3o da fibrose hep\u00e1tica em pacientes co-infectados com HIV e hepatite C n\u00e3o est\u00e1 totalmente esclarecido. Marcadores n\u00e3o-invasivos de fibrose hep\u00e1tica podem ser considerados promissores no estadiamento e na monitoriza\u00e7\u00e3o da sua evolu\u00e7\u00e3o. M\u00c9TODOS: Um total de 24 pacientes, divididos em dois grupos: 12 monoinfectados por HIV e 12 co-infectados com HIV e HCV foram acompanhados de julho de 2008 a agosto de 2009, desde o in\u00edcio de HAART, a cada tr\u00eas meses, com avalia\u00e7\u00e3o de dados cl\u00ednicos, epidemiol\u00f3gicos e laboratoriais, assim como o c\u00e1lculo do \u00edndice da rela\u00e7\u00e3o aspartato aminotransferase sobre plaquetas. O objetivo deste estudo foi comparar a progress\u00e3o de APRI, marcador n\u00e3o-invasivo de fibrose hep\u00e1tica, entre popula\u00e7\u00f5es portadoras do v\u00edrus do HIV e co-infectados com HIV e HCV. RESULTADOS: Os grupos estudados n\u00e3o mostraram diferen\u00e7as quando avaliados idade, sexo, medida de CD4 e carga viral para HIV em todas visitas, tipo de HAART e APRI antes do in\u00edcio de HAART. O grupo de pacientes co-infectados com HIV e HCV apresentava APRI significativamente maior que o grupo de monoinfectados por HIV no terceiro (0,57 + 0,31 x 0,27 + 0,05, p = 0,02) e sexto m\u00eas (0,93 + 0,79 x 0,28 + 0,11, p = 0,04). CONCLUS\u00d5ES: Neste estudo, HAART foi associado com aumento de APRI no terceiro e sexto m\u00eas de seguimento nos pacientes co-infectados, sugerindo que nestes pode estar ocorrendo hepatotoxicidade cumulativa e s\u00edndrome inflamat\u00f3ria da reconstitui\u00e7\u00e3o imune ap\u00f3s in\u00edcio dos antirretrovirais.<\/jats:p>","DOI":"10.1590\/s0037-86822010000600015","type":"journal-article","created":{"date-parts":[[2010,12,20]],"date-time":"2010-12-20T06:28:55Z","timestamp":1292826535000},"page":"678-681","source":"Crossref","is-referenced-by-count":1,"title":["Uso do score APRI na avalia\u00e7\u00e3o de doen\u00e7a hep\u00e1tica, ap\u00f3s in\u00edcio de terapia antirretroviral, em pacientes portadores do HIV co-infectados com HCV versus monoinfectados por HIV"],"prefix":"10.1590","volume":"43","author":[{"given":"Vicente Sperb","family":"Antonello","sequence":"first","affiliation":[{"name":"Hospital Nossa Senhora da Concei\u00e7\u00e3o; Hospital F\u00eamina; Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiane Valle","family":"Tovo","sequence":"additional","affiliation":[{"name":"Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre; Hospital Nossa Senhora da Concei\u00e7\u00e3o,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimas Alexandre","family":"Kliemann","sequence":"additional","affiliation":[{"name":"Hospital Nossa Senhora da Concei\u00e7\u00e3o"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Breno Riegel","family":"Santos","sequence":"additional","affiliation":[{"name":"Hospital Nossa Senhora da Concei\u00e7\u00e3o"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanice Ferrazza","family":"Zaltron","sequence":"additional","affiliation":[{"name":"Hospitalar Santa Casa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","series-title":"Principles and Practice of Infectious Diseases","first-page":"1619","volume-title":"Global Perspectives on Human Immunodeficiency Virus Infection and Acquired Immunodeficiency Syndrome","author":"Piot P","year":"2009","edition":"7th"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1056\/NEJM199803263381301","article-title":"Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. 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