{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T15:47:47Z","timestamp":1648655267789},"reference-count":34,"publisher":"FapUNIFESP (SciELO)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Soc. Bras. Med. Trop."],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:p>INTRODU\u00c7\u00c3O: Neste estudo, objetivou-se caracterizar a preval\u00eancia e o perfil de suscetibilidade de cepas de Staphylococcus coagulase negatives resistentes \u00e0 oxacilina isoladas de culturas de sangue, em um hospital escola, localizado na Cidade de Santa Maria. Al\u00e9m disso, buscou-se comparar ao teste genot\u00edpico de refer\u00eancia, diferentes metodologias fenot\u00edpicas para a caracteriza\u00e7\u00e3o da resist\u00eancia mediada pelo gene mecA. M\u00c9TODOS: Ap\u00f3s identifica\u00e7\u00e3o (MicroScan\u00ae - Siemens), os isolados foram submetidos a testes de sensibilidade antimicrobiana a partir da difus\u00e3o do disco e automa\u00e7\u00e3o (MicroScan\u00ae - Siemens). A presen\u00e7a do gene mecA foi evidenciada atrav\u00e9s da t\u00e9cnica molecular de rea\u00e7\u00e3o em cadeia da polimerase. RESULTADOS: A esp\u00e9cie prevalente foi Staphylococcus epidermidis (67%). O gene mecA foi detectado em 90% das cepas e conforme an\u00e1lise dos perfis de sensibilidade, observou-se um \u00edndice elevado de resist\u00eancia a v\u00e1rias classes de antimicrobianos. Contudo, todos os isolados mostraram-se uniformemente sens\u00edveis \u00e0 vancomicina e tigeciclina. O disco de cefoxitina foi a metodologia fenot\u00edpica que melhor correlacionou-se com o padr\u00e3o ouro. CONCLUS\u00d5ES: A an\u00e1lise da signific\u00e2ncia cl\u00ednica de SCN isolados de hemoculturas e a detec\u00e7\u00e3o precisa da resist\u00eancia \u00e0 oxacilina representam fatores decisivos para a institui\u00e7\u00e3o correta da antibioticoterapia. Apesar da vancomicina constituir o tratamento usual na maioria dos hospitais brasileiros, tem a redu\u00e7\u00e3o de seu emprego recomendada.<\/jats:p>","DOI":"10.1590\/s0037-86822010000600017","type":"journal-article","created":{"date-parts":[[2010,12,20]],"date-time":"2010-12-20T06:29:23Z","timestamp":1292826563000},"page":"686-690","source":"Crossref","is-referenced-by-count":3,"title":["Bacteremias por Staphylococcus coagulase negativos oxacilina resistentes em um hospital escola na cidade de Santa Maria, Estado do Rio Grande do Sul"],"prefix":"10.1590","volume":"43","author":[{"given":"Fabiane","family":"Rigatti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u00edsa Kraulich","family":"Tizotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosmari","family":"H\u00f6rner","sequence":"additional","affiliation":[{"name":"Universidade Federal de Santa Maria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa Oliveira","family":"Domingues","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosi\u00e9li","family":"Martini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Let\u00edcia Eichstaedt","family":"Mayer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e1bio Teixeira","family":"Khun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chirles Ara\u00fajo de","family":"Fran\u00e7a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mateus Matiuzzi 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