{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:24:16Z","timestamp":1787235856496,"version":"build-2736575974"},"reference-count":13,"publisher":"FapUNIFESP (SciELO)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Soc. Bras. Med. Trop."],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:p>INTRODUCTION: Histoplasmosis is a systemic mycosis endemic in Brazil, especially in the State of Rio Grande do Sul, where Histoplasma capsulatum was isolated from the soil. H. capsulatum may compromise unusual areas, including the oropharynx, particularly in patients presenting disseminated histoplasmosis; which is associated with a state of immunosuppression, such as AIDS. METHODS: During database analysis of a total of 265 cases of histoplasmosis, the medical records of 11 patients with histological or microbiological diagnoses of oral histoplasmosis (OH) between 1987 and 2008 were retrospectively reviewed. RESULTS: This work reports 11 cases of OH, the majority presenting histopathological or microbiological evidence of disseminated histoplasmosis (DH). In the patients with DH, OH was the first manifestation of histoplasmosis. Five of the 11 patients discussed were HIV-seropositive with clinical and laboratory findings of AIDS. Four patients presented active pulmonary tuberculosis concomitant with histoplasmosis. Treatment was based on the use of itraconazole and amphotericin B deoxycholate. Eight patients responded successfully to therapy after one year, two did not come back for reevaluation and one died despite adequate therapy. CONCLUSIONS: Oral histoplasmosis is closely associated with immunosuppression status, especially in patients presenting AIDS; moreover, in many cases, OH is the first sign of disseminated histoplasmosis.<\/jats:p>","DOI":"10.1590\/s0037-86822011000100007","type":"journal-article","created":{"date-parts":[[2011,4,15]],"date-time":"2011-04-15T21:13:36Z","timestamp":1302902016000},"page":"26-29","source":"Crossref","is-referenced-by-count":36,"title":["Oropharyngeal histoplasmosis: report of eleven cases and review of the literature"],"prefix":"10.1590","volume":"44","author":[{"given":"Vicente Sperb","family":"Antonello","sequence":"first","affiliation":[{"name":"Hospital Nossa Senhora da Concei\u00e7\u00e3o,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanice Ferrazza","family":"Zaltron","sequence":"additional","affiliation":[{"name":"Complexo Hospitalar Santa Casa de Porto Alegr,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela","family":"Vial","sequence":"additional","affiliation":[{"name":"University of Passo Fundo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00e1vio Mattos de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Complexo Hospitalar Santa Casa de Porto Alegre,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Carlos","family":"Severo","sequence":"additional","affiliation":[{"name":"Complexo Hospitalar Santa Casa de Porto Alegre,  Brazil; Federal University of Rio Grande do Sul,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","series-title":"Principles and Practice of Infectious Diseases","first-page":"3305","volume-title":"Histoplasma capsulatum","author":"Deepe Jr 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AIDS","volume":"30","author":"d\u00b4\u00c1vila SCGP","year":"1997","journal-title":"Rev Soc Bras Med Trop","ISSN":"https:\/\/id.crossref.org\/issn\/0037-8682","issn-type":"print"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.diagmicrobio.2006.01.015","article-title":"Gastrointestinal histoplasmosis in the acquired immunodeficiency syndrome: report of 18 cases and literature review","volume":"55","author":"Assi M","year":"2006","journal-title":"Diagn Microbiol Infect Dis","ISSN":"https:\/\/id.crossref.org\/issn\/0732-8893","issn-type":"print"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1590\/S0036-46652001000400001","article-title":"Histoplasmosis in Rio Grande do Sul, Brazil: a 21-year experience","volume":"43","author":"Severo LC","year":"2001","journal-title":"Rev Inst Med Trop Sao Paulo","ISSN":"https:\/\/id.crossref.org\/issn\/0036-4665","issn-type":"print"},{"key":"ref10","first-page":"167","article-title":"Disseminated histoplasmosis in patients with acquired immunodeficiency syndrome (AIDS): Study of 25 cases","volume":"36","author":"Rocha MM","year":"1994","journal-title":"Rev Inst Med Trop Sao Paulo","ISSN":"https:\/\/id.crossref.org\/issn\/0036-4665","issn-type":"print"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/j.1600-0714.1997.tb01240.x","article-title":"Localised oral histoplasmosis lesions associated with HIV infection","volume":"26","author":"Warnakulasuriya KA","year":"1997","journal-title":"J Oral Pathol Med","ISSN":"https:\/\/id.crossref.org\/issn\/0904-2512","issn-type":"print"},{"key":"ref12","first-page":"164","article-title":"Disseminated histoplasmosis with lesions restricted to the larynx in a patient with AIDS: Report of a case and review of the literature","volume":"24","author":"Solari 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