{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T12:42:19Z","timestamp":1707309739279},"reference-count":43,"publisher":"FapUNIFESP (SciELO)","issue":"suppl 2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Soc. Bras. Med. Trop."],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>A partir do ciclo enzo\u00f3tico silvestre do Trypanosoma cruzi, a doen\u00e7a de Chagas humana (DCH) emergiu esparsa e focalmente em diferentes pontos do Continente Americano, havendo in\u00edcios de sua ocorr\u00eancia em \u00e9pocas pr\u00e9 crist\u00e3s. Dispersada por subsequentes hordas de migra\u00e7\u00f5es internas, a DCH instalou-se em locais onde os insetos vetores se domiciliavam e diferentes reservat\u00f3rios se aproximavam dos assentamentos humanos. Ganhou maior expans\u00e3o no per\u00edodo p\u00f3s colombiano, em particular entre o final do s\u00e9culo XIX e meados do s\u00e9culo XX, quando atingiu seus picos de preval\u00eancia. Nos prim\u00f3rdios da doen\u00e7a h\u00e1 ind\u00edcios esparsos de casos agudos, cardiopatia cr\u00f4nica e megac\u00f3lon em diferentes pontos da Regi\u00e3o, mas esses quadros se encontram sujeitos a confus\u00e3o diagn\u00f3stica. Por outro lado, o megaes\u00f4fago se mostra o marcador de maior especificidade na DCH, havendo numerosos registros de sua ocorr\u00eancia em v\u00e1rios pontos do Brasil, especialmente a partir do s\u00e9culo XVIII. O peso m\u00e9dico social da DCH corresponde inequivocamente \u00e0 ocorr\u00eancia da cardiopatia chag\u00e1sica cr\u00f4nica, tendo sido a partir justamente de sua caracteriza\u00e7\u00e3o que foram deflagradas em definitivo as a\u00e7\u00f5es de controle da enfermidade nos pa\u00edses end\u00eamicos.<\/jats:p>","DOI":"10.1590\/s0037-86822011000800002","type":"journal-article","created":{"date-parts":[[2011,5,12]],"date-time":"2011-05-12T14:53:12Z","timestamp":1305211992000},"page":"6-11","source":"Crossref","is-referenced-by-count":2,"title":["Os prim\u00f3rdios da doen\u00e7a"],"prefix":"10.1590","volume":"44","author":[{"given":"Alu\u00edzio","family":"Prata","sequence":"first","affiliation":[{"name":"Universidade Federal do Tri\u00e2ngulo Mineiro"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Carlos Pinto","family":"Dias","sequence":"additional","affiliation":[{"name":"FIOCRUZ"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 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