{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T21:40:53Z","timestamp":1793396453877,"version":"4.5.0"},"reference-count":32,"publisher":"FapUNIFESP (SciELO)","issue":"suppl 2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Soc. Bras. Med. Trop."],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>Um inqu\u00e9rito de soropreval\u00eancia de doen\u00e7a de Chagas foi realizado em amostra representativa da popula\u00e7\u00e3o com idade at\u00e9 cinco anos de toda a \u00e1rea rural brasileira, exceto o Estado do Rio de Janeiro. Foram estudadas 104.954 crian\u00e7as, que tiveram amostras de sangue coletadas em papel de filtro e submetidas a testes de screening pelas t\u00e9cnicas de imunofluoresc\u00eancia indireta (IFI) e ELISA em um \u00fanico laborat\u00f3rio. Todas as amostras com resultados positivos ou indeterminados, juntamente com 10% daquelas com resultados negativos, foram enviadas para um laborat\u00f3rio de refer\u00eancia e a\u00ed submetidas a novos testes por IFI e ELISA, al\u00e9m de western blot TESA (Trypomastigote Excreted Secreted Antigen). Para as crian\u00e7as com resultado final positivo foi agendada uma re-visita para coleta de sangue venoso do pr\u00f3prio participante e das suas m\u00e3es e familiares. Da avalia\u00e7\u00e3o do conjunto de testes resultaram 104 (0,1%) resultados positivos, dos quais apenas 32 (0,03%) foram confirmadas como infectadas. Destas, 20 (0,02%) com positividade materna concomitante (sugerindo transmiss\u00e3o cong\u00eanita), 11 (0,01%) com positividade apenas na crian\u00e7a (indicativo de prov\u00e1vel transmiss\u00e3o vetorial), e uma crian\u00e7a positiva cuja m\u00e3e havia falecido. Em 41 situa\u00e7\u00f5es ocorreu confirma\u00e7\u00e3o apenas nas m\u00e3es, sugerindo transfer\u00eancia passiva de anticorpos maternos; em 18 a positividade n\u00e3o se confirmou nem nas crian\u00e7as nem nas suas m\u00e3es; e em 13 n\u00e3o foi poss\u00edvel a localiza\u00e7\u00e3o de ambas. As 11 crian\u00e7as que adquiriram a infec\u00e7\u00e3o por prov\u00e1vel via vetorial distribu\u00edram-se predominantemente na regi\u00e3o nordeste (Piau\u00ed, Cear\u00e1, Rio Grande do Norte, Para\u00edba e Alagoas), acrescidas de um caso no Amazonas e um no Paran\u00e1. Dos 20 casos com prov\u00e1vel transmiss\u00e3o cong\u00eanita sobressaiu-se o Rio Grande do Sul, com 60% deles, representando este o primeiro relato de diferen\u00e7as regionais na transmiss\u00e3o cong\u00eanita da doen\u00e7a de Chagas no Brasil, possivelmente relacionada \u00e0 exist\u00eancia de Trypanosoma cruzi grupo IId e IIe, atualmente classificados como TcV e TcVI. Os resultados deste inqu\u00e9rito apontam para a virtual inexist\u00eancia de transmiss\u00e3o de doen\u00e7a de Chagas por via vetorial no Brasil em anos recentes, resultante da combina\u00e7\u00e3o dos programas regulares e sistem\u00e1ticos de combate \u00e1 mol\u00e9stia e de mudan\u00e7as de natureza socioecon\u00f4mica observadas no pa\u00eds ao longo das \u00faltimas d\u00e9cadas. Por outro lado, refor\u00e7am a necessidade de manuten\u00e7\u00e3o de um programa de controle que garanta a consolida\u00e7\u00e3o deste grande avan\u00e7o.<\/jats:p>","DOI":"10.1590\/s0037-86822011000800015","type":"journal-article","created":{"date-parts":[[2011,5,12]],"date-time":"2011-05-12T14:53:46Z","timestamp":1305212026000},"page":"108-121","source":"Crossref","is-referenced-by-count":60,"title":["O inqu\u00e9rito nacional de soropreval\u00eancia de avalia\u00e7\u00e3o do controle da doen\u00e7a de Chagas no Brasil (2001-2008)"],"prefix":"10.1590","volume":"44","author":[{"given":"Alejandro Luquetti","family":"Ostermayer","sequence":"first","affiliation":[{"name":"Universidade Federal de Goi\u00e1s"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afonso Dinis Costa","family":"Passos","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f4nio Carlos","family":"Silveira","sequence":"additional","affiliation":[{"name":"Minist\u00e9rio da Sa\u00fade e Consultor da Organiza\u00e7\u00e3o Panamericana de Sa\u00fade"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Walter","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanize","family":"Macedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alu\u00edzio Rosa","family":"Prata","sequence":"additional","affiliation":[{"name":"Universidade Federal do Triangulo Mineiro"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","series-title":"Colet\u00e2nea SUCAM","volume-title":"Controle de vetores da doen\u00e7a de Chagas: Experi\u00eancia do Minist\u00e9rio da Sa\u00fade, Brasil","author":"Marques 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Chagas","year":"1980","edition":"1"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1590\/S0074-02762009000900005","article-title":"Current epidemiological trends of Chagas disease in Latin America and future challenges: epidemiology, surveillance and health policies","volume":"104","author":"Moncayo A","year":"2009","journal-title":"Mem Inst Oswaldo Cruz","ISSN":"https:\/\/id.crossref.org\/issn\/0074-0276","issn-type":"print"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1590\/S0036-46651984000400003","article-title":"Inqu\u00e9rito sorol\u00f3gico da preval\u00eancia de infec\u00e7\u00e3o chag\u00e1sica no Brasil, 1975\/1980","volume":"26","author":"Camargo ME","year":"1984","journal-title":"Rev Inst Med Trop S\u00e3o Paulo","ISSN":"https:\/\/id.crossref.org\/issn\/0036-4665","issn-type":"print"},{"key":"ref12","year":"2007"},{"key":"ref13","series-title":"Censo demogr\u00e1fico de 1991"},{"key":"ref14","series-title":"Anu\u00e1rio 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small children of 5 years, and other sources","volume":"38","author":"Luquetti AO","year":"2005","journal-title":"Rev Soc Bras Med Trop","ISSN":"https:\/\/id.crossref.org\/issn\/0037-8682","issn-type":"print"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1590\/S0074-02762009000700021","article-title":"A new consensus for Trypanosoma cruzi intraspecific nomenclature: second revision meeting recommends TcI to TcVI","volume":"104","author":"Zingales B","year":"2009","journal-title":"Mem Inst Oswaldo Cruz","ISSN":"https:\/\/id.crossref.org\/issn\/0074-0276","issn-type":"print"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/0035-9203(86)90347-0","article-title":"Trypanosoma cruzi: zymodemes associated with acute and chronic Chagas'disease in central Brazil","volume":"80","author":"Luquetti AO","year":"1986","journal-title":"Trans Roy Soc Trop Med Hyg"},{"key":"ref30","first-page":"28","article-title":"Detecci\u00f3n de la 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