{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T20:44:31Z","timestamp":1693341871968},"reference-count":22,"publisher":"FapUNIFESP (SciELO)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Soc. Bras. Med. Trop."],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:p>INTRODUCTION: Authors describe human schistosomal granuloma in late chronic phase, from the morphological and evolutionary viewpoints. METHODS: The study was based on a histological analysis of two fragments obtained from a surgical biopsy of peritoneum and large intestine of a 42-year-old patient, with a pseudotumoral form mimicking a peritoneal carcinomatosis associated to the schistosomiasis hepatointestinal form. RESULTS: Two hundred and three granulomas were identified in the pseudotumor and 27 in the intestinal biopsy, with similar morphological features, most in the late chronic phase, in fibrotic healing. A new structural classification was suggested for granulomas: zone 1 (internal), 2 (intermediate) and 3 (external). CONCLUSIONS: Regarding granuloma as a whole, we may conclude that fibrosis is likely to be controlled by different and independent mechanisms in the three zones of the granuloma. Lamellar fibrosis in zone 3 seems to be controlled by matrix mesenchymal cells (fibroblasts and myoepithelial cells) and by inflammatory exudate cells (lymphocytes, plasmocytes, neutrophils, eosinophils). Annular fibrosis in zone 2, comprising a dense fibrous connective tissue, with few cells in the advanced phase, would be controlled by epithelioid cells involving zone 1 in recent granulomas. In zone 1, replacing periovular necrosis, an initialy loose and tracery connective neoformation, housing stellate cells or with fusiform nuclei, a dense paucicellular nodular connctive tissue emerges, probably induced by fibroblasts. In several granulomas, one of the zones is missing and granuloma is represented by two of them: Z3 and Z2, Z3 and Z1 or Z2 and Z1 and, ultimately, by a scar.<\/jats:p>","DOI":"10.1590\/s0037-86822012000500016","type":"journal-article","created":{"date-parts":[[2012,11,14]],"date-time":"2012-11-14T04:29:23Z","timestamp":1352867363000},"page":"627-632","source":"Crossref","is-referenced-by-count":3,"title":["Schistosoma mansoni granuloma in late evolutive phase, in a case of tumoral form in man"],"prefix":"10.1590","volume":"45","author":[{"given":"Pedro","family":"Raso","sequence":"first","affiliation":[{"name":"Universidade Federal de Minas Gerais"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo Arruda Moraes","family":"Raso","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferdinan de Almeida","family":"Melo","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wagner Luiz","family":"Tafuri","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1128\/IAI.62.3.994-999.1994","article-title":"Cloning of THO - and TH2: type helper lymphocytes from liver granuloma of Schistosoma mansoni-infected mice","volume":"62","author":"Zhu Y","year":"1944","journal-title":"Infect Immunol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1128\/CMR.2.3.250","article-title":"Immunopathology of Schistosoma mansoni Infection","volume":"2","author":"Boros DL","year":"1989","journal-title":"Clin Microbiol Reviews"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1073\/pnas.0305064101","article-title":"IL-13 receptor alfa2 down-modulates granulomatous inflamation and prolongs host survival in schistosomiasis","volume":"102","author":"Mentik-Kane M","year":"2004","journal-title":"Proc Acad Sci USA"},{"key":"ref4","first-page":"147","article-title":"Contribui\u00e7\u00e3o ao conhecimento do quadro anat\u00f4mico do f\u00edgado na forma tox\u00eamica da esquistossomose mansoni atrav\u00e9s de pun\u00e7\u00f5es-bi\u00f3psias","volume":"22","author":"Raso P","year":"1965","journal-title":"An Fac Med Univ Fed Minas Gerais","ISSN":"http:\/\/id.crossref.org\/issn\/0100-235X","issn-type":"print"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1590\/S0037-86821978000100008","article-title":"As dimens\u00f5es do granuloma causado pelos ovos do S. mansoni no f\u00edgado humano","volume":"12","author":"Raso P","year":"1976","journal-title":"Rev Soc Bras Med Trop","ISSN":"http:\/\/id.crossref.org\/issn\/0037-8682","issn-type":"print"},{"key":"ref6","first-page":"70","author":"Raso P","year":"1970"},{"key":"ref7","series-title":"Bogliolo Patologia","first-page":"1337","volume-title":"Esquistossomose mans\u00f4nica","author":"Raso P","year":"2006","edition":"7"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0035-9203(64)90068-9","article-title":"Mild prolonged schistosomiasis in mice: alterations in host response with time and the development of portal fibrosis","volume":"58","author":"Andrade ZA","year":"1964","journal-title":"Trans R Soc Trop Med Hyg","ISSN":"http:\/\/id.crossref.org\/issn\/0035-9203","issn-type":"print"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1590\/S0037-86821994000300001","article-title":"Schistosoma mansoni in mice: modulation of granulomatous response after reinfection and chemotherapeutic treatment","volume":"27","author":"Coelho PMZ","year":"1994","journal-title":"Rev Soc Bras Med Trop","ISSN":"http:\/\/id.crossref.org\/issn\/0037-8682","issn-type":"print"},{"key":"ref10","series-title":"Patologia experimental com enfoque no granuloma esquistossom\u00f3tico: uma vis\u00e3o multidisciplinar","first-page":"569","author":"Lenzi HL","year":"2008"},{"key":"ref11","first-page":"47","article-title":"Picrosirino staining plus polarization microscopy, a specific method for collagen detection in tissues sections","volume":"11","author":"Junqueira LCV","year":"1979","journal-title":"Histochem J","ISSN":"http:\/\/id.crossref.org\/issn\/0018-2214","issn-type":"print"},{"key":"ref12","first-page":"993","article-title":"The Hoepply phenomenon in schistosomiasis: II. 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