{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T18:54:11Z","timestamp":1649184851386},"reference-count":6,"publisher":"FapUNIFESP (SciELO)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Soc. Bras. Med. Trop."],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:p>The treatment of chronic hepatitis C has frequent side effects such as cytopenias and neuropsychiatric symptoms. However, pulmonary toxicity associated with interferon is rarely described. This paper describes the clinical case of a 67-year-old female patient with chronic hepatitis C who presented an acute onset of dry cough, dyspnoea, and fever 36 weeks after the use of pegylated interferon alfa-2a and ribavirin. The lung biopsy confirmed the diagnosis of a bronchiolitis obliterans organizing pneumonia (BOOP). Corticotherapy was initiated, with clinical and radiological improvement. This paper aims to advise physicians to this occasional, though severe, adverse event related to hepatitis C virus (HCV) treatment.<\/jats:p>","DOI":"10.1590\/s0037-86822012000500023","type":"journal-article","created":{"date-parts":[[2012,11,13]],"date-time":"2012-11-13T23:29:49Z","timestamp":1352849389000},"page":"655-656","source":"Crossref","is-referenced-by-count":5,"title":["Secondary bronchiolitis obliterans organizing pneumonia during treatment of chronic hepatitis C: role of pegylated interferon alfa-2a"],"prefix":"10.1590","volume":"45","author":[{"given":"Ronaldo Soares","family":"Martins","sequence":"first","affiliation":[{"name":"Hospital Fel\u00edcio Rocho; Universidade Federal de Minas Gerais"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliano Antunes","family":"Machado","sequence":"additional","affiliation":[{"name":"Hospital Fel\u00edcio Rocho; Universidade Federal de Minas Gerais"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ros\u00e2ngela","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais; Universidade Federal de Minas Gerais"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1378\/chest.106.2.612","article-title":"Interferon-related bronchiolitis obliterans organizing pneumonia","volume":"106","author":"Ogata K","year":"1994","journal-title":"Chest","ISSN":"http:\/\/id.crossref.org\/issn\/0012-3692","issn-type":"print"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1378\/chest.124.1.406","article-title":"Pegylated interferon and ribavirininduced interstitial pneumonitis with ARDS","volume":"124","author":"Abi-Nassif S","year":"2003","journal-title":"Chest","ISSN":"http:\/\/id.crossref.org\/issn\/0012-3692","issn-type":"print"},{"key":"ref3","doi-asserted-by":"crossref","DOI":"10.1164\/ajrccm.162.5.9906096","article-title":"Characteristic elevation of matrix metalloproteinase activity in idiopathic interstitial pneumonias","volume":"162","author":"Suga M","year":"2000","journal-title":"Am J Respir Crit Care Med","ISSN":"http:\/\/id.crossref.org\/issn\/1073-449X","issn-type":"print"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S1579-2129(08)60033-6","article-title":"Organizing pneumonia associated with the use of pegylated interferon alfa","volume":"44","author":"Vila JCT","year":"2008","journal-title":"Arch Bronconeumol","ISSN":"http:\/\/id.crossref.org\/issn\/0300-2896","issn-type":"print"},{"key":"ref5","article-title":"Pharmacokinetics of peginterferons","volume":"23","author":"Zeuzem S","year":"2003","journal-title":"Semin Liver Dis","ISSN":"http:\/\/id.crossref.org\/issn\/0272-8087","issn-type":"print"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s10620-009-0797-1","article-title":"Pneumonitis as a Consequence of (Peg) Interferon-Ribavirin Combination Therapy for Hepatitis C: a Review of the Literature","volume":"55","author":"Slavenburg S","year":"2010","journal-title":"Dig Dis Sci","ISSN":"http:\/\/id.crossref.org\/issn\/0163-2116","issn-type":"print"}],"container-title":["Revista da Sociedade Brasileira de Medicina Tropical"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/rsbmt\/v45n5\/v45n5a23.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,5,27]],"date-time":"2017-05-27T06:29:20Z","timestamp":1495866560000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0037-86822012000500023&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":6,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["S0037-86822012000500023"],"URL":"https:\/\/doi.org\/10.1590\/s0037-86822012000500023","relation":{},"ISSN":["0037-8682"],"issn-type":[{"value":"0037-8682","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10]]}}}